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Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia

Author(s): Heers M; Afnan J; Braun C; Grova C; Altenmüller DM; Steinhoff BJ; Dümpelmann M; Demerath T; Urbach H; Ethofer S; Siegel M; Schulze-Bonhage A; Lerche H; Li Hegner Y;

Objective: Focal cortical dysplasia (FCD) causes drug-resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta ( ...

Article GUID: 41804684


Nonphotochemical Spectral Hole Burning Study of Modified LH2 Complex from em Rbl. acidophilus /em : Do Parts of the Pigment Molecule Affect Small Light-Induced Structural Changes?

Author(s): Levenberg A; Trempe A; Lujan MA; Picorel R; Zazubovich V;

Nonphotochemical spectral hole burning (NPHB) experiments were performed on the modified LH2 complex from Rbl. acidophilus, in which some but not all B800 Bchl a molecules have been replaced with Chl a, with the initial goal of utilizing Chl a as a local thermometer. The focus of the work eventually shifted to exploring low-temperature protein dynamics. D ...

Article GUID: 41802209


Habitual napping in older adults is accompanied by altered heat-loss rhythms across the circadian cycle and reduced coupling between pre-sleep thermoregulatory dynamics and sleep initiation

Author(s): Dourte M; Hammad G; de Haan S; Deantoni M; Reyt M; Baillet M; Lesoinne A; Muto V; Collette F; Vandewalle G; Peigneux P; Cajochen C; Schmidt C;

Thermoregulatory processes are closely linked to sleep initiation and maintenance throughout the circadian cycle, and may contribute to the increased tendency to nap in older adults. This cross-sectional study examined whether habitual napping in healthy older individuals is associated with alter ...

Article GUID: 41797810


Trajectories of Alcohol-Related Problems Among First-Year Nursing Students: Nature, Predictors, and Outcomes

Author(s): Cheyroux P; Morin AJS; O' Connor RM; Colombat P; Vancappel A; Eltanoukhi R; Gillet N;

This study aims to contribute to an improved dynamic person-centred comprehension of the distinct trajectories of alcohol-related problems observed among first-year nursing students. Data was collected from 2963 first-year nursing students on four occasions over the course of their first semester ...

Article GUID: 41797206


Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial

Author(s): Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC;

Introduction: It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). Methods: We conducted a 12-month randomized trial comparing P ...

Article GUID: 41795685


Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome

Author(s): Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G;

Background: Metabolic Syndrome (MetS) presents a global health challenge, characterized by obesity, hypertension, dyslipidemia, and insulin resistance. Despite recognition of the gut microbiome's role in metabolic health, there remains scope for defining association of unique microbes with cl ...

Article GUID: 41794383


Season and city shape urban bioaerosol composition beyond vegetation and socioeconomic gradients

Author(s): Poirier S; Rondeau-Leclaire J; Faticov M; Roy A; Lajeunesse G; Lucier JF; Tardif S; Kembel SW; Ziter C; Laprise C; Paquette A; Girard C; Laforest-Lapointe I;

Urban vegetation varies with socio-economic gradients, as lower-income neighborhoods often host sparser and less diverse green spaces. This disparity may affect respiratory health by influencing exposure to bioaerosols. Understanding the characteristics of this aerobiome could help anticipate ris ...

Article GUID: 41785576


Blending Poly(dimethylsiloxane) with Poly(lactic acid) Using Polyhydroxyurethane Additives

Author(s): Younes GR; Heli B; Ajji A;

This work blends polydimethylsiloxane (PDMS) with poly-(lactic acid) (PLA) using polyhydroxyurethane (PHU) structures. The PHU is synthesized from mannitol biscarbonate and a short-chain PDMS-based diamine. The main objectives are, first, to explore the application of the PDMS-based PHU as an additive for PLA and, second, to enhance the flexibility and hy ...

Article GUID: 41783236


Phenogenomics reveals the ecology and evolution of Trichoderma fungi for sustainable agriculture

Author(s): Steindorff AS; Cai FM; Ding M; Jiang S; Atanasova L; Baker SE; Barbosa-Filho JR; Bayram Akcapinar G; Brown DW; Chaverri P; Chen P; Chenthamara K; Daum C; Drula E; Dubey M; Brandström Durling M; Flatschacher D; Ebner T; Emri T; Gao R; Geo ...

Trichoderma fungi support sustainable agriculture by suppressing plant diseases and improving crop performance. However, emerging pathogenicity of Trichoderma warrants further ecological and genetic characterization. Here we used machine learning to correlate genomic data from 37 Trichoderma stra ...

Article GUID: 41775999


Shared effects of one s own and others experiences during reinforcement learning on episodic memory

Author(s): Woitow MA; Jang AI; Eppinger B; Nassar MR; Brass M; Rodriguez Buritica JM;

Humans learn not only from their own experiences but also by observing others. Prior research has shown that reward prediction errors (RPEs) - the difference between expected and received outcomes - guide both experiential and observational reinforcement learning. While RPEs from direct experience have been linked to memory formation, it remains unclear w ...

Article GUID: 41764305


Thermal sonogenetics for adoptive cell transfer therapy

Author(s): Baez A; Hazel K; Guertin Z; Fong E; Manus MM; Kaloyannis A; Helfield B;

Adoptive cell transfer (ACT)-based immunotherapy has emerged as a transformative approach for treating cancer, offering durable responses through the ex vivo expansion and reinfusion of antigen-specific immune cells. Despite remarkable clinical successes, most notably with chimeric antigen receptor (CAR)-T cell therapy, ACT remains limited by severe toxic ...

Article GUID: 41748028


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