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Multilevel Estimation of the Relative Impacts of Social Determinants on Income-Related Health Inequalities in Urban Canada: Protocol for the Canadian Social Determinants Urban Laboratory

Author(s): Plante C; Datta Gupta S; Bandara T; Beland D; Blaser C; Camillo CA; Villa E; Dutton D; Fuller D; Hasselback J; Lix LM; Marouzi A; Muhajarine N; Notten G; Reimer B; Wolfson M; Young M; Concha DY; Neudorf C;

Background: Two decades of research have highlighted persistent income-related health inequities in Canada across municipal, provincial, and national levels. While there is broad consensus among researchers, advocates, and health professionals that social determinants are the primary drivers of h ...

Article GUID: 41313634


Web-Based Formal Versus Informal Mindfulness Programs for University Students With and Those Without Recent Self-Injury: Randomized Controlled Trial

Author(s): Petrovic J; Mettler J; Böke BN; Rogers MA; Hamza CA; Bloom E; Di Genova L; Romano V; Heath NL;

Background: Mindfulness-based programming (MBP) is increasingly being implemented within university settings to support students' mental health, and it typically includes the instruction of formal mindfulness (FM) and informal mindfulness (IM) activities. However, recent evidence suggests tha ...

Article GUID: 41313154


Isolation of Marine Bacteria through a "Bait" Approach

Author(s): Pakseresht B; Schiffman Z; McLatchie S; Coulombe P; Soullane S; Imfeld A; Gélinas Y; Walsh D; Findlay B;

There is a great divide between the microbes active in natural environments and the organisms that may be grown in a laboratory setting. In this work we set out to cultivate representatives of the marine myxobacterial clade, a highly diverse, largely-uncultured group of Gram-negative bacteria bel ...

Article GUID: 41297029


Mechanochemically-mediated dynamic imine bond conjugation for drug delivery using carbon dots

Author(s): Fuoco G; Mandl GA; De Mesa C; Capobianco JA; Naccache R;

Efficient delivery of therapeutics remains a significant challenge, often hindered by solubility barriers encountered within aqueous biological environments. Carbon dots (CDs) offer a promising solution for drug delivery due to their aqueous dispersibility, generally low cytotoxicity and surfaces rich in functional groups which can enable facile conjugati ...

Article GUID: 41288467


Revealing pH-dependent antimicrobial peptide, GL13K, characteristics: A constant pH molecular dynamics study

Author(s): Hamidabad MN; Mansbach RA;

Antimicrobial peptides (AMPs) are a promising potential solution to combat antimicrobial resistance (AMR) due to their positive charges, which induce selective interaction with negatively charged bacterial membranes. Certain AMPs exhibit a low hemolytic index and non-forming fibrils at physiological pH (7.4), enhancing their therapeutic potential. In this ...

Article GUID: 41256587


Weight bias, stigma and discrimination: a call for greater conceptual clarity

Author(s): Côté M; Forouhar V; Sacco S; Baillot A; Himmelstein M; Hussey B; Incollingo Rodriguez AC; Nagpal TS; Nutter S; Patton I; Pearl RL; Puhl RM; Ramos Salas X; Russell-Mayhew S; Alberga AS;

Article GUID: 41280193


Tri-Functional CRISPR Screen Reveals Overexpression of em QDR2 /em and em QDR3 /em Transporters Increase Fumaric Acid Production in em Kluyveromyces marxianus /em

Author(s): Thornbury M; Omran RP; Kumar L; Knoops A; Abushahin R; Whiteway M; Martin VJJ;

Organic acids such as fumaric acid are widely used in the food and beverage industry as acidulants and preservatives, while also serving as versatile precursors for industrially relevant compounds. Fumaric acid is still predominantly produced through petroleum-derived processes. To enhance production efficiency and diversify supply, we are engineering Klu ...

Article GUID: 41277095


Biotuner: A python toolbox integrating music theory and signal processing for harmonic analysis of physiological and natural time series

Author(s): Bellemare-Pepin A; Jerbi K;

Background: The Biotuner Toolbox is an open-source Python toolbox for biosignals that integrates concepts from neuroscience, music theory, and signal processing. It introduces a harmonic perspective on physiological oscillations by applying musical constructs such as consonance, rhythm, and scale construction. Methods: The core biotuner_object processes ...

Article GUID: 41269470


Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy

Author(s): Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivière S; Caciagli L; Pana R; Weil AG; Grova C; Frauscher B; Schrader DV; Zhang Z; Concha L; Bernasc ...

Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 d ...

Article GUID: 41258102


Mechanistic insights of plant-microbe interactions for enhancing the growth and productivity of plants under salt stress conditions for agricultural sustainability

Author(s): Sharma B; Negi R; Jyothi SR; Gupta A; Jhamta S; Yadav N; Kaur N; Puri P; Thakur SS; Bagavathiappan S; Thakur N; Shreaz S; Madouh TA; Yadav AN;

According to estimates from United Nations environmental program, salinity affects about 20% of agricultural land and 50% of farmland worldwide. Plants react to salinity stress by undergoing distinctive physiochemical, morphological, and molecular adaptations. Nonetheless, a number of mitigating ...

Article GUID: 41245209


Temporal and Sex-Related Differences in Knee Biomechanics Over the Course of the Varsity Athletic Season: Pre- and Postseason Knee Kinematics in Collegiate Varsity Athletes Using Kinect

Author(s): Joseph T; Babouras A; Zhao KY; Corban J; Martineau PA;

Background: Anterior cruciate ligament (ACL) tears can be a source of significant morbidity, with the potential for career-altering implications for athletes who sustain them. Specific knee biomechanics during a drop vertical jump have been shown to be associated with an increased risk for ACL injury in collegiate varsity athletes. Presently, the evolutio ...

Article GUID: 41230424


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