Author(s): Min XZ; Zhang X; Xie ZY; Nikolaev A; Vorkamp K; Ma JM; Reiersen LO; Li L; Cai MH; Ren NQ; Li YF; Zhang ZF; Kallenborn R; Muir D;

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs an ...

Article GUID: 41571477

Author(s): Bellemare-Pepin A; Lespinasse F; Thölke P; Harel Y; Mathewson K; Olson JA; Bengio Y; Jerbi K;

The recent surge of Large Language Models (LLMs) has led to claims that they are approaching a level of creativity akin to human capabilities. This idea has sparked a blend of excitement and apprehension. However, a critical piece that has been missing in this discourse is a systematic evaluation ...

Article GUID: 41565675

Author(s): Presta D; Bergdahl A;

Maximal oxygen consumption (VO2 max) reflects the greatest amount of oxygen utilized upon exertion. Blood flow restriction (BFR) limits venous return, enabling low-intensity exercise to yield adaptations like high-intensity training. This study examined whether 5 weeks of online resistance training (RT) with BFR straps improves VO2, tidal volume, and resp ...

Article GUID: 41565628

Author(s): Díaz-Muñoz C; Bozzarelli I; Lopera-Maya EA; Belbasis L; Lo Faro V; Camargo Tavares L; Heredia-Fernández F; Di Lorenzo B; Sinha T; Esteban Blanco C; Favé MJ; Awadalla P; Walters RG; Bonfiglio F; Zhernakova A; Sanna S; D' Amato M;

Background: Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. Objective: To identify genes and mechanisms involved in gut motility, providing a foundation for cli ...

Article GUID: 41558814

Author(s): Seralini GE; Jungers G; Andersen A; Antoniou M; Aschner M; Bacon MH; Bertrand M; Bohn T; Bonfleur ML; Bücking E; Defarge N; Djemil R; Domingo JL; Douzelet J; Fagan J; Fournier T; Garcia JLY; Gil S; Hervé-Gruyer P; Hilbeck A; Hilty L; Hub ...

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petr ...

Article GUID: 41551494

Author(s): Hassø RK; Lindtofte S; Kosik B; Bergdahl A; Larsen S;

Article GUID: 41553522

Author(s): Sui J; Bi H; Yue R; Fu H; Yang A; An C;

Persistent oil contamination along coastlines can be treated by surface washing agents (SWAs), while low-temperature conditions can significantly impact the effectiveness of SWAs in oil removal. This study investigates the oil removal performance of a commercial SWA for oiled shoreline sand in cold-region environments. Batch oil removal tests were conduct ...

Article GUID: 41544565

Author(s): Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain ...

Article GUID: 41543005

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Zhang XN; Shamei A; Grond F; Verduyckt I; Bouserhal RE;

Speech takes place in physical environments with visual and acoustic properties, yet how these elements and their interaction influence speech production is not fully understood. While a room's appearance can suggest its acoustics, it is unclear whether people adjust their speech based on this visual information. Previous research shows that higher re ...

Article GUID: 41528171

Author(s): MacKay A; Zsombor-Pindera J; Effaty F; Sheibany N; Gennarini F; Habibian M; Chen F; Askari MS; Brytskyi M; Kroeker S; Kennepohl P; Ottenwaelder X;

Redox noninnocent ligands present opportunities to access reactive metal-radical complexes, but competing redox pathways often hinder their selective formation. Here, a pentadentate arylhydroxylamine-containing (ArNHOH) ligand directs copper salts to form a single, well-defined CuII-arylnitrosyl ...

Article GUID: 41524899