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Revealing pH-dependent antimicrobial peptide, GL13K, characteristics: A constant pH molecular dynamics study

Author(s): Hamidabad MN; Mansbach RA;

Antimicrobial peptides (AMPs) are a promising potential solution to combat antimicrobial resistance (AMR) due to their positive charges, which induce selective interaction with negatively charged bacterial membranes. Certain AMPs exhibit a low hemolytic index and non-forming fibrils at physiological pH (7.4), enhancing their therapeutic potential. In this ...

Article GUID: 41256587


In Silico Study of the Early Stages of Aggregation of β-Sheet Forming Antimicrobial Peptide GL13K

Author(s): Hamidabad MN; Watson NA; Wright LN; Mansbach RA;

Antimicrobial peptides (AMPs) are of growing interest as potential candidates that may offer more resilience against antimicrobial resistance than traditional antibiotic agents. In this article, we perform the first in silico study of the synthetic ß sheet-forming AMP GL13K. Through atomistic simulations of single and multi-peptide systems under different ...

Article GUID: 38572930


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