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Large scale laboratory evolution uncovers clinically relevant collateral antibiotic sensitivity

Author(s): Chowdhury FR; Banari V; Lesnic V; Zhanel GG; Findlay BL;

The increasing prevalence of antibiotic resistance is a critical challenge, necessitating the development of strategies to mitigate the evolution of resistance. Collateral sensitivity (CS)-based sequential therapies have been proposed to mitigate resistance evolution. However, the evolutionary repeatability of CS across different experimental conditions a ...

Article GUID: 40615056


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