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Benchmarking macaque brain gene expression for horizontal and vertical translation

Author(s): Luppi AI; Liu ZQ; Hansen JY; Cofre R; Niu M; Kuzmin E; Froudist-Walsh S; Palomero-Gallagher N; Misic B;

The spatial patterning of gene expression shapes cortical organization and function. The macaque is a fundamental model organism in neuroscience, but the translational potential of macaque gene expression rests on the assumption that it is a good proxy for patterns of corresponding proteins (vert ...

Article GUID: 40020056


Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

Author(s): Hansen JY; Markello RD; Tuominen L; Nørgaard M; Kuzmin E; Palomero-Gallagher N; Dagher A; Misic B;

Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcript ...

Article GUID: 36209794


Numerical uncertainty in analytical pipelines lead to impactful variability in brain networks

Author(s): Kiar G; Chatelain Y; de Oliveira Castro P; Petit E; Rokem A; Varoquaux G; Misic B; Evans AC; Glatard T;

The analysis of brain-imaging data requires complex processing pipelines to support findings on brain function or pathologies. Recent work has shown that variability in analytical decisions, small amounts of noise, or computational environments can lead to substantial differences in the results, ...

Article GUID: 34724000


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