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A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

Author(s): McCallum G; Burckhardt JC; He J; Hong A; Potvin-Trottier L; Tropini C;

The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet non-invasive monitoring tools remain limited. Genetically tractable commensals, including Bacteroides thetaiotaomicron, ...

Article GUID: 41610848


The gut microbiota and its biogeography

Author(s): McCallum G; Tropini C;

Biogeography is the study of species distribution and diversity within an ecosystem and is at the core of how we understand ecosystem dynamics and interactions at the macroscale. In gut microbial communities, a historical reliance on bulk sequencing to probe community composition and dynamics has overlooked critical processes whereby microscale interactio ...

Article GUID: 37740073


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