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Interpersonal Capitalization and Unmet Interpersonal Needs Among Adolescents at Varying Risk for Suicidal Ideation: A Daily Diary Study

Author(s): Perezmontemayor Cruz I; MacNeil S; Renaud J; Gouin JP;

Introduction: Adolescents at risk for suicidal ideation tend to report more unmet interpersonal needs, namely perceived burdensomeness and thwarted belongingness. Interpersonal capitalization-an interpersonal process involving disclosing a positive personal event to others and evaluating others' responsiveness to such disclosure-can promote positive a ...

Article GUID: 41928498


Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment

Author(s): Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T;

Background: Subcortical ischemic vascular cognitive impairment (SIVCI) is characterized by white matter hyperintensities (WMH) that contribute to executive dysfunction and increased risk of Alzheimer's disease. Cognitive reserve (CR) is the brain's ability to maintain cognitive performance despite pathology. Resting-state functional connectivity ( ...

Article GUID: 41929984


Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor-Dependent Manner

Author(s): Gholizadeh F; Hajiaghayi M; Rahbari N; Choi JS; Heidt S; Como A; Kazerouni M; Kargar M; Pinard-LaRoche A; Shih SCC; Darlington PJ;

Memory T helper (Th) cells sustain protective recall responses but can also drive chronic inflammation, necessitating precise regulation of their effector programs. Although Th cells produce acetylcholine (ACh) and express nicotinic acetylcholine receptors (nAChRs), the contribution of nAChRs to ...

Article GUID: 41928597


Assessing Port-related Greenhouse Gas Emissions and Mitigation Pathways Through a Comprehensive Framework Applied to the Vancouver Fraser Port Authority

Author(s): Wang Z; Su Y; Lu Z; An C;

Maritime transport is a major contributor to greenhouse gas (GHG) emissions, and ports play a critical role in shaping regional and national decarbonization pathways. This study develops a comprehensive framework to quantify both offshore and onshore GHG emissions associated with port activities and applies it to the Vancouver Fraser Port Authority (VFPA) ...

Article GUID: 41925888


Different behavioral measures of conditioned magazine activity can tell different stories about brain function

Author(s): Volz S; Loewinger G; Marquez I; Fevola S; Kang M; Reverte I; Krishnan A; Gardner MPH; Iordanova MD; Esber GR;

Elucidating the neural substrates of Pavlovian reward learning requires reliable behavioral readouts. In conditioned magazine approach studies, rodents express reward expectancy by approaching the food magazine during cues that predict reward. This behavior is typically quantified using one of th ...

Article GUID: 41922165


Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions

Author(s): Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM;

White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative etiology. Current imaging methods have lacked the specificity to disentangle biological processes ...

Article GUID: 41916976


Social exclusion, but not withdrawal, is diminished by a friend s level of acceptance: A provisions model

Author(s): Commisso M; Bukowski WM;

Using the Actor-Partner-Interdependence Model, a friend's level of peer acceptance on the stability of a child's social withdrawal and peer exclusion was assessed with a sample of 252 fifth- and sixth-grade girls and boys of European and North-African descent from lower- and upper-middle class neighborhoods in Montreal, Quebec, in 2015/2016. Socio ...

Article GUID: 41914693


eDNA Provides Accurate Population Abundance Estimates With Bioenergetics and Particle Mass-Balance Modelling

Author(s): Beaulieu J; Yates MC; Fraser DJ; Cristescu ME; Derry AM;

Anthropogenic activities have led to an unprecedented crisis in freshwater biodiversity loss. The capacity to monitor the abundance of wild populations is critical to conserving biodiversity, but conventional physical specimen collection methods are invasive, costly and labour-intensive. Environmental DNA (eDNA) offers a promising alternative, being easy ...

Article GUID: 41913704


Management of brain-heart multimorbidity: a clinical practice guideline

Author(s): Edwards JD; Li Z; McFarlane P; Rabi DM; Gilbert J; Bajaj HS; MacIntosh BJ; Bittman J; Feldman RD; Dresser G; Terenzi K; Swartz R; Gabor J; Pearson GJ; Selby P; Wharton S; Warburton DER; Pakhalé S; Styra R; Baker B; Tu K; Hawkins M; Stone ...

Background: Although brain and heart conditions share overlapping risk factors and commonly co-occur, current cardiac and neurologic clinical guidelines are typically produced within specialty silos. The objective of this guideline from a Canadian Cardiovascular Harmonized National Guideline Ende ...

Article GUID: 41912243


Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner

Author(s): Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ;

Introduction: Cancers often drive T cells toward an exhausted state characterized by impaired cytotoxicity and upregulation of inhibitory receptors (PD-1, TIM-3, CD38) and transcriptional regulators (TOX, NFATc1). Repeated stimulation in vitro is used to model this process, reflecting chronic antigen exposure in the tumor microenvironment. Stress-derived ...

Article GUID: 41906691


Investigating Workplace Bullying Using a Person-Centered Approach: Capturing Targets Exposure and Sense of Defenselessness Through Latent Profile Analysis

Author(s): Trépanier SG; Notelaers G; Birkeland Nielsen M; Morin AJS;

Workplace bullying is conceptualized as a systematic exposure to harassing behavior accompanied by feelings of defenselessness. Yet, most research has solely focused on exposure, thereby ignoring the role of defenselessness regarding victimization from bullying. Using a person-centered approach, this cross-sectional study addresses this gap by investigati ...

Article GUID: 41902650


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