Author(s): Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L;

Background: In recent years, many studies have investigated the effects of non-pharmacological interventions (e.g. physical and cognitive training) on cognition in patients with mild cognitive impairment. The SYNERGIC trial showed that combining physical exercise and cognitive training leads to g ...

Article GUID: 41447475

Author(s): Rehan S; Mehrabi F; Mick P; Phillips NA;

Background: Sensory and psychosocial factors are potentially modifiable risk factors for dementia. Social factors and indicators of mental health are associated with cognitive performance and risk for Alzheimer's disease (AD). Sensory impairment can lead to communication and mobility difficulties, reducing social engagement and possibly accelerating c ...

Article GUID: 41447555

Author(s): Sorin C; Phillips NA;

Background: During the COVID-19 pandemic, older adults were considered vulnerable to declines in well-being, especially those with preexisting cognitive impairments. However, qualitative studies have focused on the resilience of cognitively-unimpaired older adults during the pandemic. Therefore, the present study employed both quantitative and qualitative ...

Article GUID: 41447242

Author(s): Jobin B; Frasnelli J; Phillips NA; Boller B;

Background: Olfactory identification is impaired early in the clinical continuum of Alzheimer's disease (AD) and is already observable in mild cognitive impairment (MCI). A recent meta-analysis showed significant associations between olfactory identification and episodic memory scores in older adults without cognitive impairment. Thus, olfactory ident ...

Article GUID: 41443638

Author(s): Grant N; Phillips NA;

Background: Age-related hearing loss (HL) is associated with poorer cognition and increased risk of developing dementia. However, few studies have explored if sex affects the association between HL and cognition. We investigated the relationship between two hearing measures and performance on cognitive screening and neuropsychological tests in males and f ...

Article GUID: 41443651

Author(s): Kouzoukas E; Navas C; Zawertailo L; Fougere C; Bacon SL; Chadi N; Evans WK; McNeill A; Melamed O; Moraes TJ; Nnorom O; Schwartz R; Shahab L; Ween M; Selby P;

Objective: To develop evidence-informed recommendations on the health effects of e-cigarettes to guide healthcare practitioners and the public to balance individual and population harm reduction. Methods: Systematic and umbrella reviews investigating the health effects of e-cigarette use were co ...

Article GUID: 41443121

Author(s): Tristin Best

Background: Olfactory dysfunction is a prevalent and early symptom of Alzheimer's disease (AD), often preceding the core memory impairment features of AD. Moreover, brain regions integral to olfactory processing are implicated in the early AD pathophysiology. Previous work has identified olfactory deficits in individuals with subjective cognitive decl ...

Article GUID: 41441548

Author(s): Mosharafian S; Jaeger JAG;

Rapid increases in urban sprawl in many cities across the planet pose a challenge that needs to be addressed urgently. This study proposes targets, limits, and warning values to urban sprawl as a quantitative reference framework for exploring potential future pathways and to provide guidance for future land management. The reference framework serves to ev ...

Article GUID: 41436679

Author(s): Hervé V; KaAli OB; Benali H; Brouillette J;

Background: One of the main neuropathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid-beta oligomers (Aßo), which begins in the brain approximately 15 years prior to the onset of clinical symptoms. Aßo-induced neuronal hyperactivity has emerged as an early functional characteristic of AD, contributing to synaptic deficits, ...

Article GUID: 41436083

Author(s): Intzandt B; Potvin-Jutras Z; Whittingstall K; Gauthier CJ;

Background: Circulating sex hormones decrease in aging, influencing cerebrovascular health, a key factor in dementia risk. Early menopause is a risk factor for dementia comparable to smoking2. Estradiol consistently supports female vasculature1 and brain health, though its effects on cerebrovascular health is understudied. Testosterone's effects in ma ...

Article GUID: 41433411

Author(s): Silva NCBS; Stein RG; Gu Y; Hsu CL; Tam RC; Salluzzi M; McCreary CR; Alkeridy WA; Lam K; MacKay AL; Kolind S; Cossette B; Griffith LE; Hogan DB; McMillan JM; Raina P; Smith EE; Liu-Ambrose T;

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19 and has infected >700 million persons worldwide. Individuals infected with SARS-CoV-2 are at risk for cognitive decline and at higher risk of dementia compared with those diagnosed with oth ...

Article GUID: 41434542