Author(s): Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC;

Introduction: It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). Methods: We conducted a 12-month randomized trial comparing P ...

Article GUID: 41795685

Author(s): Notton C; Sharma V; Quoc-Huy Trinh V; Chen L; Xu M; Varma S; Hosseini MS;

Colorectal cancer (CRC) is one of the few cancers that have an established dysplasia-carcinoma sequence that benefits from screening. Everyone over 50 years of age in Canada is eligible for CRC screening. About 20% of those people will undergo a biopsy for a pre-neoplastic polyp and, in many cases, multiple polyps. As such, these polyp biopsies make up th ...

Article GUID: 41793844

Author(s): Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G;

Background: Metabolic Syndrome (MetS) presents a global health challenge, characterized by obesity, hypertension, dyslipidemia, and insulin resistance. Despite recognition of the gut microbiome's role in metabolic health, there remains scope for defining association of unique microbes with cl ...

Article GUID: 41794383

Author(s): Guo D; Luo Z; Bouguila N; Fan W;

Neural topic models (NTMs) based on variational autoencoders (VAEs) have emerged as a scalable and flexible alternative to classical probabilistic models for uncovering latent thematic structures in text corpora. However, most existing NTMs either overlook the geometric structure of word embeddings or rely on Euclidean priors that are poorly aligned with ...

Article GUID: 41791177

Author(s): Poirier S; Rondeau-Leclaire J; Faticov M; Roy A; Lajeunesse G; Lucier JF; Tardif S; Kembel SW; Ziter C; Laprise C; Paquette A; Girard C; Laforest-Lapointe I;

Urban vegetation varies with socio-economic gradients, as lower-income neighborhoods often host sparser and less diverse green spaces. This disparity may affect respiratory health by influencing exposure to bioaerosols. Understanding the characteristics of this aerobiome could help anticipate ris ...

Article GUID: 41785576

Author(s): Younes GR; Heli B; Ajji A;

This work blends polydimethylsiloxane (PDMS) with poly-(lactic acid) (PLA) using polyhydroxyurethane (PHU) structures. The PHU is synthesized from mannitol biscarbonate and a short-chain PDMS-based diamine. The main objectives are, first, to explore the application of the PDMS-based PHU as an additive for PLA and, second, to enhance the flexibility and hy ...

Article GUID: 41783236

Author(s): Soontjens O; Busner J; Fortin M;

Introduction: The Achilles tendon (AT) plays a crucial role in force transmission and movement efficiency, and greater tendon stiffness may enhance elastic energy storage and improve performance in explosive movements. Shear-wave elastography (SWE) enables reliable, non-invasive assessment of tendon stiffness, yet its associations with other ultrasound (U ...

Article GUID: 41783785

Author(s): Narcross L; Pyne ME; Kevvai K; Siu KH; Dueber JE; Martin VJJ;

The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises >2,500 members, including the pharmaceuticals morphine, codeine, and papaverine, as well as the antibiotics sanguinarine and chelerythrine. Agricultural cultivation can supply the demand for the BIAs that accumulate in plants, but broader access to the BIA family wou ...

Article GUID: 41779670

Author(s): Steindorff AS; Cai FM; Ding M; Jiang S; Atanasova L; Baker SE; Barbosa-Filho JR; Bayram Akcapinar G; Brown DW; Chaverri P; Chen P; Chenthamara K; Daum C; Drula E; Dubey M; Brandström Durling M; Flatschacher D; Ebner T; Emri T; Gao R; Geo ...

Trichoderma fungi support sustainable agriculture by suppressing plant diseases and improving crop performance. However, emerging pathogenicity of Trichoderma warrants further ecological and genetic characterization. Here we used machine learning to correlate genomic data from 37 Trichoderma stra ...

Article GUID: 41775999

Author(s): Woitow MA; Jang AI; Eppinger B; Nassar MR; Brass M; Rodriguez Buritica JM;

Humans learn not only from their own experiences but also by observing others. Prior research has shown that reward prediction errors (RPEs) - the difference between expected and received outcomes - guide both experiential and observational reinforcement learning. While RPEs from direct experience have been linked to memory formation, it remains unclear w ...

Article GUID: 41764305

Author(s): Baez A; Hazel K; Guertin Z; Fong E; Manus MM; Kaloyannis A; Helfield B;

Adoptive cell transfer (ACT)-based immunotherapy has emerged as a transformative approach for treating cancer, offering durable responses through the ex vivo expansion and reinfusion of antigen-specific immune cells. Despite remarkable clinical successes, most notably with chimeric antigen receptor (CAR)-T cell therapy, ACT remains limited by severe toxic ...

Article GUID: 41748028