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Enhanced identification of membrane transport proteins: a hybrid approach combining ProtBERT-BFD and convolutional neural networks

Author(s): Ghazikhani H; Butler G;

Transmembrane transport proteins (transporters) play a crucial role in the fundamental cellular processes of all organisms by facilitating the transport of hydrophilic substrates across hydrophobic membranes. Despite the availability of numerous membrane protein sequences, their structures and functions remain largely elusive. Recently, natural language p ...

Article GUID: 37497772


Modeling venous bias in resting state functional MRI metrics

Author(s): Huck J; Jäger AT; Schneider U; Grahl S; Fan AP; Tardif C; Villringer A; Bazin PL; Steele CJ; Gauthier CJ;

Resting-state (rs) functional magnetic resonance imaging (fMRI) is used to detect low-frequency fluctuations in the blood oxygen-level dependent (BOLD) signal across brain regions. Correlations between temporal BOLD signal fluctuations are commonly used to infer functional connectivity. However, ...

Article GUID: 37498014


System Approach for Characterizing and Evaluating Factors for Occupational Health Impacts Due to Nonfatal Injuries and Illnesses for the Use in Life Cycle Assessment

Author(s): Huang Z; Kijko G; Scanlon K; Lloyd S; Henderson A; Fantke P; Jolliet O; Li S;

Occupational injuries and illnesses are major risk factors for human health impacts worldwide, but they have not been consistently nor comprehensively considered in life cycle impact assessment (LCIA) methods. In this study, we quantified occupational health impacts as disability-adjusted life years (DALYs) for nonfatal injuries and illnesses in all US in ...

Article GUID: 37490771


Performance of ChatGPT on a Practice Dermatology Board Certification Examination

Author(s): Joly-Chevrier M; Nguyen AX; Lesko-Krleza M; Lefrançois P;

No abstract

Article GUID: 37489920


Joint frequency space design approach for efficient planar frequency diverse arrays

Author(s): Hasheminasab M; Cheldavi A; Kishk AA;

Antenna arrays offer advantages in terms of spatial diversity, allowing for control over pattern specifications in space. The incorporation of frequency diversity in arrays presents an opportunity to manipulate beams in the Space-Time domain. Unlike conventional arrays, Frequency Diverse Arrays (FDA) with added frequency diversity exhibit time-variant and ...

Article GUID: 37482579


Overlooked Role of Bulk Nanobubbles in the Alteration and Motion of Microplastics in the Ocean Environment

Author(s): Wang Z; An C; Lee K; Feng Q;

The increasing enrichment of microplastics (MPs) in the shoreline environment poses both ecological and social-economic risks. The alteration and motion of MPs in the ocean under the effect of bulk nanobubbles (NBs) have been less extensively studied. In this study, we explored the behavior and movement of various MPs in the presence of bulk NBs. The role ...

Article GUID: 37477614


Editorial: Computational systems immunovirology

Author(s): Zarei Ghobadi M; Teymoori-Rad M; Selvaraj G; Wei DQ;

No abstract available

Article GUID: 37475870


Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial

Author(s): Montero-Odasso M; Zou G; Speechley M; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li KZH; Fraser S; Pieruccini-Faria F; Berryman N; Lussier M; Shoemaker JK; Son S; Bherer L;

Importance: Exercise, cognitive training, and vitamin D may enhance cognition in older adults with mild cognitive impairment (MCI). Objective: To determine whether aerobic-resistance exercises would improve cognition relative to an active control and if a multidomain intervention including exerc ...

Article GUID: 37471089


Monkeys who experience more feeding competition utilize social information to learn foraging skills faster

Author(s): Arseneau-Robar TJM; Anderson KA; Sicotte P; Teichroeb JA;

Animals must learn foraging skills to successfully survive and reproduce but the sources of interindividual variation in learning are poorly understood. For example, there is little consensus on the role motivation plays, even though it is a key factor impacting learning outcomes in humans. Here, we conduct a field experiment on a wild primate to investig ...

Article GUID: 37468534


Online Gambling Practices and Related Problems in Five European Countries: Findings from the Electronic Gam(bl)ing Multinational Empirical Survey (E-GAMES) Project

Author(s): Costes JM; Kairouz S; Fiedler I; Bartczuk RP; Lelonkek-Kuleta B; Minutillo A; Notari L;

Online gambling has demonstrated a significant and growing impact on overall gambling involvement. To examine online gambling practices and associated problems, we conducted surveys with national samples of Internet users in several European countries. The objective of this paper is to provide a portrait of online gambling practices and problems in five E ...

Article GUID: 37466781


Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography

Author(s): Lander AJ; Mercado LD; Li X; Taily IM; Findlay BL; Jin Y; Luk LYP;

Tryptophan is frequently found on the surface of membrane-associated proteins that interact with the lipid membrane. However, because of their multifaceted interactions, it is difficult to pinpoint the structure-activity relationship of each tryptophan residue. Here, we describe the use of racemic protein crystallography to probe dedicated tryptophan inte ...

Article GUID: 37464011


Spaced Apart: Autoethnographies of Access Throughout the COVID 19 Pandemic

Author(s): Dokumaci A; Bessette-Viens R; Goberdhan N; Lucas S; Mazowita A; Stainton J;

In this article, we present six autoethnographies of lives marked by crisis that reflect on the issues of access, very broadly defined, that the COVID 19 pandemic has raised or redefined for each of us. As the time of crisis has made access concerns more and more evident it also exposes how access is not an issue just for disabled people, but for all live ...

Article GUID: 37461398


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