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A resistome survey across hundreds of freshwater bacterial communities reveals the impacts of veterinary and human antibiotics use

Author(s): Kraemer SA; Barbosa da Costa N; Oliva A; Huot Y; Walsh DA;

Our decreasing ability to fight bacterial infections is a major health concern. It is arising due to the evolution of antimicrobial resistance (AMR) in response to the mis- and overuse of antibiotics in both human and veterinary medicine. Lakes integrate watershed processes and thus may act as receptors and reservoirs of antibiotic resistance genes (ARGs) ...

Article GUID: 36338036


Who's cooking tonight? A time-use study of coupled adults in Toronto, Canada

Author(s): Liu B; Widener MJ; Smith LG; Farber S; Gesink D; Minaker LM; Patterson Z; Larsen K; Gilliland J;

Understanding how coupled adults arrange food-related labor in relation to their daily time allocation is of great importance because different arrangements may have implications for diet-related health and gender equity. Studies from the time-use perspective argue that daily activities such as w ...

Article GUID: 36339032


The Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala During the First Extinction Episode Has Persistent Effects on Extinction Expression

Author(s): Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD;

Background: Adaptive behavior depends on the delicate and dynamic balance between acquisition and extinction memories. Disruption of this balance, particularly when the extinction of memory loses control over behavior, is the root of treatment failure of maladaptive behaviors such as substance abuse or anxiety disorders. Understanding this balance require ...

Article GUID: 36336498


Combining elements of the CO-OP Approach™ with education to promote healthy eating among older adults: A pilot study

Author(s): Dawson DR; Bar Y; Ajwani F; Rotenberg S; Atlas B; Ricupero M; Greewood C; Parrott MD;

This paper describes an exploratory study developing the Baycrest Brain-healthy Eating Approach (BBEA). Poor diet is a modifiable risk factor for many health problems including dementia. Mediterranean type diets, high in plant-based foods, rich in poly- and mono- unsaturated fatty acids with minimal consumption of saturated fat, red meat, and processed fo ...

Article GUID: 36338514


How well do covariates perform when adjusting for sampling bias in online COVID-19 research? Insights from multiverse analyses

Author(s): Joyal-Desmarais K; Stojanovic J; Kennedy EB; Enticott JC; Boucher VG; Vo H; Košir U; Lavoie KL; Bacon SL;

COVID-19 research has relied heavily on convenience-based samples, which-though often necessary-are susceptible to important sampling biases. We begin with a theoretical overview and introduction to the dynamics that underlie sampling bias. We then empirically examine sampling bias in online COVI ...

Article GUID: 36335560


The caleosin CLO7 and its role in the heterotrimeric G-protein signalling network

Author(s): Brunetti SC; Arseneault MKM; Gulick PJ;

The investigation of the caleosin CLO7 in relation to heterotrimeric G-protein signalling in Arabidopsis showed that the gene plays a role in seed germination and embryo viability. The caleosin CLO7 belongs to a multi-gene family of calcium-binding proteins which are characterized by single EF-hand motifs. Other members of the caleosin gene family have be ...

Article GUID: 36334585


Positive and negative actions early in the relationship predict later interactions among toddlers

Author(s): Lahat A; Lou Z; Perlman M; Howe N; Santo JB; Recchia HE; Bukowski WM; Ross HS;

Very little is known about the role of early interactions in the development of peer relationships among toddlers. The present study examined whether behaviors early in the formation of toddler relationships predict interactions later in their relationships. Twenty-eight unfamiliar 20- and 30-month-old toddlers from a predominately European background met ...

Article GUID: 36327252


Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses

Author(s): Cuesta S; Burdisso P; Segev A; Kourrich S; Sperandio V;

Gut-microbiota membership is associated with diverse neuropsychological outcomes, including substance use disorders (SUDs). Here, we use mice colonized with Citrobacter rodentium or the human ?-Proteobacteria commensal Escherichia coli HS as a model to examine the mechanistic interactions between gut microbes and host responses to cocaine. We find that co ...

Article GUID: 36323315


An Intensive Ambulatory Care Program for Adolescents With Eating Disorders Combining In-Person and Web-Based Care: Protocol for a Single-Site Naturalistic Trial

Author(s): Novack K; Dufour R; Picard L; Booij L; Chadi N;

Background: The incidence of eating disorders (EDs) among adolescents has significantly increased since the beginning of the COVID-19 pandemic. Hybrid care, which combines web-based and in-person modalities, is a promising approach for adolescents with EDs but remains understudied in this population. Objective: We aimed to implement a novel hybrid (web-b ...

Article GUID: 36322118


Economic burden of insomnia symptoms in Canada

Author(s): Chaput JP; Janssen I; Sampasa-Kanyinga H; Carney CE; Dang-Vu TT; Davidson JR; Robillard R; Morin CM;

Objective: To estimate health care and productivity costs associated with insomnia symptoms in Canadian adults. Methods: Three pieces of information were needed to calculate estimates based on a prevalence-based approach: (1) the pooled relative risk estimates of health outcomes consistently ass ...

Article GUID: 36319579


LIST: A Newly Developed Laser-assisted Cell Bioprinting Technology

Author(s): Roversi K; Orimi HE; Erfanian M; Talbot S; Boutopoulos C;

Cell bioprinting technologies aim to fabricate tissue-like constructs by delivering biomaterials layer-by-layer. Bioprinted constructs can reduce the use of animals in drug development and hold promise for addressing the shortage of organs for transplants. We recently introduced a laser-assisted drop-on-demand bioprinting technology termed Laser Induced S ...

Article GUID: 36313198


Novelty detection in rover-based planetary surface images using autoencoders

Author(s): Stefanuk B; Skonieczny K;

In the domain of planetary science, novelty detection is gaining attention because of the operational opportunities it offers, including annotated data products and downlink prioritization. Using a variational autoencoder (VAE), this work improves upon state-of-the-art novelty detection performance in the context of Martian exploration by > 7 % (measured ...

Article GUID: 36313243


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