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Fluid flow influences ultrasound-assisted endothelial membrane permeabilization and calcium flux

Author(s): Memari E; Hui F; Yusefi H; Helfield B;

The local fluid dynamics experienced by circulating microbubbles vary across different anatomical sites, which can influence ultrasound-mediated therapeutic delivery efficacy. This study aimed to elucidate the effect of fluid flow rate in combination with repeated short-pulse ultrasound on microbubble-mediated endothelial cell permeabilization. Here, a ...

Article GUID: 37150403


Identification of Genes Involved in the Degradation of Lignocellulose Using Comparative Transcriptomics

Author(s): Gruninger RJ; Tsang A; McAllister TA;

Lignocellulosic biomass represents an abundant, renewable resource that can be used to produce biofuels, low-cost livestock feed, and high-value chemicals. The potential of this bioresource has led to intensive research efforts to develop cost-effective methods to break down lignocellulose. The efficiency with which the anaerobic fungi (phylum Neocallim ...

Article GUID: 37149538


Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas

Author(s): Afnan J; von Ellenrieder N; Lina JM; Pellegrino G; Arcara G; Cai Z; Hedrich T; Abdallah C; Khajehpour H; Frauscher B; Gotman J; Grova C;

Background: Magnetoencephalography (MEG) is a widely used non-invasive tool to estimate brain activity with high temporal resolution. However, due to the ill-posed nature of the MEG source imaging (MSI) problem, the ability of MSI to identify accurately underlying brain sources along the cortic ...

Article GUID: 37149236


Olfactory function reflects episodic memory performance and atrophy in the medial temporal lobe in individuals at risk for Alzheimer's disease

Author(s): Papadatos Z; Phillips NA;

We examined cognitive domains and brain regions associated with olfactory performance in cognitively unimpaired older adults (CU-OAs) and individuals with or at risk for Alzheimer's Disease (AD). We compared CU-OAs (N = 55), individuals with subjective cognitive decline (SCD, N = 55), mild cognitive impairment (MCI, N = 101), and AD (N = 45) on meas ...

Article GUID: 37146503


Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis

Author(s): Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M;

Both common pain and anxiety problems are widespread, debilitating and often begin in childhood-adolescence. Twin studies indicate that this co-occurrence is likely due to shared elements of risk, rather than reciprocal causation. A joint genome-wide investigation and pathway/network-based anal ...

Article GUID: 37146008


Cooperative Sensitization Upconversion in Solution Dispersions of Co-Crystal Assemblies of Mononuclear Yb3+ and Eu3+ Complexes

Author(s): Sun G; Xie Y; Wang Y; Mandl GA; Maurizio SL; Zhang H; Ottenwaelder X; Capobianco JA; Sun L;

Lanthanide upconversion luminescence in nanoparticles has prompted continuous breakthroughs in information storage, temperature sensing, and biomedical applications, among others. Achieving upconversion luminescence at the molecular scale is still a critical challenge in modern chemistry. In this work, we explored the upconversion luminescence of soluti ...

Article GUID: 37040148


Predictors of support for anti-weight discrimination policies among Canadian adults

Author(s): Levy M; Forouhar V; Edache IY; Alberga AS;

Introduction: Weight discrimination of individuals with overweight or obesity is associated with adverse mental and physical health. Weight discrimination is prevalent in many sectors such as within workplaces, where individuals with overweight and obesity are denied the same opportunities as individuals with lower weight status, regardless of performan ...

Article GUID: 37139379


Twenty-first century adaptive teaching and individualized learning operationalized as specific blends of student-centered instructional events: A systematic review and meta-analysis

Author(s): Bernard RM; Borokhovski E; Schmid RF; Waddington DI; Pickup DI;

No abstract available

Article GUID: 37131463


Medical cannabis is effective for cancer-related pain: Quebec Cannabis Registry results

Author(s): Aprikian S; Kasvis P; Vigano M; Hachem Y; Canac-Marquis M; Vigano A;

Objectives: To evaluate the safety and effectiveness of medical cannabis (MC) in reducing pain and concurrent medications in patients with cancer. Methods: This study analysed data collected from patients with cancer who were part of the Quebec Cannabis Registry. Brief Pain Inventory (BPI), revised Edmonton Symptom Assessment System (ESAS-r) questionna ...

Article GUID: 37130724


Associations Between Cardiovascular Risk Factors and Audiometric Hearing: Findings From the Canadian Longitudinal Study on Aging

Author(s): Mick PT; Kabir R; Pichora-Fuller MK; Jones C; Moxham L; Phillips N; Urry E; Wittich W;

Objectives: The objectives of the study were to determine, among a population-based sample of Canadian adults, if risk factors for cardiovascular disease (alone and in combination) were associated with hearing loss. Cross-sectional and longitudinal associations (the latter with about 3 years of follow-up) were examined. Risk factors considered included ...

Article GUID: 37122082


Neurophysiology, Neuropsychology, and Epilepsy, in 2022: Hills We Have Climbed and Hills Ahead. Neurophysiology in epilepsy

Author(s): Frauscher B; Bénar CG; Engel JJ; Grova C; Jacobs J; Kahane P; Wiebe S; Zjilmans M; Dubeau F;

Since the discovery of the human electroencephalogram (EEG), neurophysiology techniques have become indispensable tools in our armamentarium to localize epileptic seizures. New signal analysis techniques and the prospects of artificial intelligence and big data will offer unprecedented opportun ...

Article GUID: 37119580


The Effect of Linker-to-Metal Energy Transfer on the Photooxidation Performance of an Isostructural Series of Pyrene-Based Rare-Earth Metal-Organic Frameworks

Author(s): Quezada-Novoa V; Titi HM; Villanueva FY; Wilson MWB; Howarth AJ;

The tetratopic linker, 1,3,6,8-tetrakis(p-benzoic acid)pyrene (H4 TBAPy) along with rare-earth (RE) ions is used for the synthesis of 9 isostructures of a metal-organic framework (MOF) with shp topology, named RE-CU-10 (RE = Y(III), Gd(III), Tb(III), Dy(III), Ho(III), Er(III), Tm(III), Yb(III), and Lu(III)). The synthesis of each RE-CU-10 analogue requi ...

Article GUID: 37116124


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