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Physical activity may protect myelin via modulation of high-density lipoprotein

Author(s): Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T;

Introduction: Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied. Methods: We assessed cross-sectionally wh ...

Article GUID: 39989020


Predicting Parkinson's disease trajectory using clinical and functional MRI features: A reproduction and replication study

Author(s): Germani E; Bhagwat N; Dugré M; Gau R; Montillo AA; Nguyen KP; Sokolowski A; Sharp M; Poline JB; Glatard T;

Parkinson's disease (PD) is a common neurodegenerative disorder with a poorly understood physiopathology and no established biomarkers for the diagnosis of early stages and for prediction of disease progression. Several neuroimaging biomarkers have been studied recently, but these are suscept ...

Article GUID: 39982930


The Point of No Return? Impediments to Return to Work for Injured Migrant Agricultural Workers in Two Canadian Provinces

Author(s): Mayell S; McLaughlin J; Hennebry J; Sanchez GV; Goswami P; Hanley J;

Migrant agricultural workers employed through Canada's Temporary Foreign Worker Program face serious occupational health and safety hazards, with compounded difficulties in accessing workers' compensation (WC) if they are sick or injured by the job. Little is known, however, about their ability to return to work (RTW) upon recovery-a fundamental r ...

Article GUID: 39980401


Elucidating the size distribution of p‑Phenylenediamine-Derived quinones in atmospheric particles

Author(s): Xia K; Qin M; Han M; Zhang X; Wu X; Liu M; Liu S; Wang X; Liu W; Xie Z; Yuan R; Liu Q;

Transformed from p-phenylenediamines (PPDs) antioxidant, PPD-derived quinones (PPD-Qs) have recently been recognized as emerging contaminants due to their potential negative impacts on the environment and human health. While there have been measurements of airborne PPD-Qs, the size distribution of PPD-Qs and the impact of particle size on PPD transformati ...

Article GUID: 39978217


Prosocial responses to diverse needs in urban Canadian and rural Tzotzil Maya children

Author(s): Dunfield KA; Urian R; Tavassoli N; Kleis A;

This research examined 3- to 6-year-old's prosocial responses to an unfamiliar experimenter demonstrating diverse needs (instrumental, material, and emotional) in structured tasks across two distinct cultural contexts (urban Canada/Canadian vs. rural Mexico/Tzotzil Maya). Two hundred eighty participants were recruited from preschools in Zinacantán, Me ...

Article GUID: 39977679


Linear nonreciprocal dynamics of coupled modulated systemsa)

Author(s): Wu J; Yousefzadeh B;

Waveguides subject to spatiotemporal modulations are known to exhibit nonreciprocal vibration transmission, whereby interchanging the locations of the source and receiver changes the end-to-end transmission characteristics. The scenario of typical interest is unidirectional transmission in long, weakly modulated systems: when transmission is possible in o ...

Article GUID: 39976602


A scoping review of harm reduction practices and possibilities among indigenous populations in Australia, Canada, and the United States

Author(s): Zolopa C; Clifasefi SL; Dobischok S; Gala N; Fraser-Purdy H; Phillips MK; Blackmore S; Wendt DC;

Background: There is a great diversity of traditions, practices, and experiences among the Indigenous Peoples of North America and Oceania. However, Indigenous Peoples across these regions are affected by the historical and ongoing violence of settler colonialism, resulting in disproportionately ...

Article GUID: 39970577


Web-enhanced return-to-work coordination for employees with common mental disorders: reduction of sick leave duration and relapse

Author(s): Corbière M; Mazaniello-Chézol M; Lecomte T; Guay S; Panaccio A; Giguère CÉ;

Background: Common mental disorders (CMDs) are highly prevalent in workplace settings, and have become a significant public health challenge. This study aims to assess the effectiveness of PRATICAdr, a web application facilitated by a Return-to-Work Coordinator (RTW-C), with a focus on reducing sick leave duration and preventing relapse in individuals wit ...

Article GUID: 39966766


Performance and functional assessment of the Kimera P-IV point-of-care plasmonic qPCR prototype for ultra rapid pathogen detection of chlamydia trachomatis

Author(s): Hayes J; Lee SS; Carnevale J; Shamir D; Bohbot M; Kirk AG; Paliouras M; Trifiro MA;

Current standard microbiological techniques are generally very time consuming, usually requiring 24-72 h to establish a diagnosis. Consequentially, contemporary clinical practices implement broad-spectrum antibiotic administration prior to pathogen detection, prompting the emergence of extremely dangerous antibiotic-resistant bacteria. Additionally, lengt ...

Article GUID: 39881625


Leveraging deep learning for nonlinear shape representation in anatomically parameterized statistical shape models

Author(s): Gheflati B; Mirzaei M; Rottoo S; Rivaz H;

Purpose: Statistical shape models (SSMs) are widely used for morphological assessment of anatomical structures. However, a key limitation is the need for a clear relationship between the model's shape coefficients and clinically relevant anatomical parameters. To address this limitation, this paper proposes a novel deep learning-based anatomically par ...

Article GUID: 39953355


The Caring Intensively Study: Three-Year Follow-Up Findings From a Mixed Methods Study of Children's Psychological and Behavioral Responses After PICU Hospitalization

Author(s): Rennick JE; Dougherty G; Dryden-Palmer K; Campbell-Yeo M; Knox AM; Chambers CT; Stack DM; Treherne S; Stremler R;

Objectives: To report the 3-year follow-up results of the "Caring Intensively" study, which examined children's psychological and behavioral responses after PICU hospitalization. Design: Prospective mixed methods, concurrent triangulation design. In the quantitative arm, study group (SG) and ...

Article GUID: 39950877


Identification and comprehensive characterization of moral disapproval and behavioral dysregulation-based pornography-use profiles across 42 countries

Author(s): Bothe B; Tóth-Király I; Popova N; Nagy L; Koós M; Demetrovics Z; Potenza MN; Kraus SW; Ballester-Arnal R; Batthyány D; Bergeron S; Billieux J; Briken P; Burkauskas J; Cárdenas-López G; Carvalho J; Castro-Calvo J; Chen L; Ciocca G; Corazz ...

Background and aims: The Moral Incongruence Model of Pornography Use proposes that pornography-use-related problems may be present due to problematic pornography use (PPU) and/or moral disapproval (MD) of pornography use. Despite some supporting empirical evidence, no study has tested the presenc ...

Article GUID: 39945767


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