Author(s): Esber G; Schoenbaum G; Iordanova MD;
No abstract available
Article GUID: 39805526
Author(s): Ali OBK; Vidal A; Grova C; Benali H;
Astrocytes critically shape whole-brain structure and function by forming extensive gap junctional networks that intimately and actively interact with neurons. Despite their importance, existing computational models of whole-brain activity ignore the roles of astrocytes while primarily focusing on neurons. Addressing this oversight, we introduce a biophys ...
Article GUID: 39804928
Author(s): Cantin S; Lapointe-Girard L; Boisvert I; Renaud J; Wittich W;
No abstract available
Article GUID: 39802206
Author(s): Moore C; Williams ME; Byers-Heinlein K;
Previous research suggests that monolingual children learn words more readily in contexts with referential continuity (i.e., repeated labeling of the same referent) than in contexts with referential discontinuity (i.e., referent switches). Here, we extended this work by testing monolingual and bilingual 3- and 4-year-olds' (N = 64) novel word learning ...
Article GUID: 39798202
Author(s): Teel EF; Dobney D; Friedman D; Grilli L; Beaulieu C; Gagnon IJ;
Context: In line with emerging research, an interprofessional specialty concussion clinic instituted a policy change permitting earlier physiotherapy-based treatment entry. Our objective was to determine the effect of this policy change on concussion recovery outcomes. Design: Secondary analysis of prospectively collected clinical data. Methods: 600 you ...
Article GUID: 39798559
Author(s): Hazel K; Singh D; He S; Guertin Z; Husser MC; Helfield B;
CRISPR-Cas9 ribonucleoproteins (RNPs) have been heavily considered for gene therapy due to their high on-target efficiency, rapid activity and lack of insertional mutagenesis relative to other CRISPR-Cas9 delivery formats. Genetic diseases such as hypertrophic cardiomyopathy currently lack effective treatment strategies and are prime targets for CRISPR-Ca ...
Article GUID: 39797397
Author(s): Alasmar Z; Chakravarty MM; Penhune VB; Steele CJ;
The cortex and cerebellum are densely connected through reciprocal input/output projections that form segregated circuits. These circuits are shown to differentially connect anterior lobules of the cerebellum to sensorimotor regions, and lobules Crus I and II to prefrontal regions. This differential connectivity pattern leads to the hypothesis that indivi ...
Article GUID: 39791308
Author(s): Soucy JP; Belasso CJ; Cai Z; Bezgin G; Stevenson J; Rahmouni N; Tissot C; Lussier FZ; Rosa-Neto P; Rivaz HJ; Benali H;
Background: Tau aggregates in Alzheimer's disease (AD) induce loss of synapses and neurons, leading to cognitive impairment. Predicting tau and neurodegeneration temporal evolution could be used for prognostication and for assessing results of therapeutic trials. Tau PET and MRI volumetry are ...
Article GUID: 39782975
Author(s): Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;
Background: Alzheimer's disease (AD) is thought to result from a complex cascade of events involving several pathological processes. Recent studies have reported alterations in white matter (WM) microstructure in the early phase of AD, but WM remains understudied. We used a multivariate appro ...
Article GUID: 39782998
Author(s): Soucy JP; Belasso CJ; Cai Z; Bezgin G; Stevenson J; Rahmouni N; Tissot C; Lussier FZ; Rosa-Neto P; Rivaz HJ; Benali H;
Background: Tau aggregates in Alzheimer's disease (AD) induce loss of synapses and neurons, leading to cognitive impairment. Predicting tau and neurodegeneration temporal evolution could be used for prognostication and for assessing results of therapeutic trials. Tau PET and MRI volumetry are ...
Article GUID: 39784152
Author(s): Tremblay SA; Spreng RN; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;
Background: Alzheimer's disease (AD) is thought to result from a complex cascade of events involving several pathological processes. Recent studies have reported alterations in white matter (WM) microstructure in the early phase of AD, but WM remains understudied. We used a multivariate appro ...
Article GUID: 39785351
Author(s): Grant N; Phillips N;
Background: Hearing loss (HL) is a risk factor for dementia that is prevalent in older adults. Altered brain connectivity is present in individuals with HL, individuals with subjective cognitive decline (SCD), and individuals with mild cognitive impairment (MCI). In individuals with HL, altered brain connectivity has been associated with impaired scores o ...
Article GUID: 39785420
