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Phylogenomic fingerprinting of tempo and functions of horizontal gene transfer within ochrophytes.

Author(s): Dorrell RG, Villain A, Perez-Lamarque B, Audren de Kerdrel G, McCallum G, Watson AK, Ait-Mohamed O, Alberti A, Corre E, Frischkorn KR, Pierella Karlusich JJ, Pelletier E, Morlon H, Bowler C, Blanc G

Horizontal gene transfer (HGT) is an important source of novelty in eukaryotic genomes. This is particularly true for the ochrophytes, a diverse and important group of algae. Previous studies have shown that ochrophytes possess a mosaic of genes derived from bacteria and eukaryotic algae, acqui ...

Article GUID: 33419955


Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity.

Author(s): Olajide OJ, Gbadamosi IT, Yawson EO, Arogundade T, Lewu FS, Ogunrinola KY, Adigun OO, Bamisi O, Lambe E, Arietarhire LO, Oluyomi OO, Idowu OK, Kareem R, Asogwa NT, Adeniyi PA

The hallmarks of Alzheimer's disease (AD) pathology include senile plaques accumulation and neurofibrillary tangles, which is thought to underlie synaptic failure. Recent evidence however supports that synaptic failure in AD may instead be instigated by enhanced N-methyl-D-aspartate (NMDA) ...

Article GUID: 33420680


Environmental Multimedia Modeling System (EMMS) for Health Risk Assessment: Key Influencing Factors and Uncertainties Researches.

Author(s): Yuan J, Chen Z, Ding S, Zhang Q, Jia Y

In this paper, a former developed Environmental Multimedia Modeling System (EMMS) combining with risk assessment Monte Carlo Method (MCM) was further used for exploring the interaction between groundwater and surface water. When using this EMMS-MCM simulation, this paper concentrate on combining several influencing factors on its permeability coefficien ...

Article GUID: 33410257


Change in Pain Status and Subsequent Opioid and Marijuana Use Among Long-Term Adult Survivors of Childhood Cancer.

Author(s): Huang IC, Alberts NM, Buckley MG, Li Z, Ehrhardt MJ, Brinkman TM, Allen J, Krull KR, Klosky JL, Greene WL, Srivastava DK, Robison LL, Hudson MM, Anghelescu DL

We evaluated pain status change and associations with subsequent opioid/marijuana use among 1208 adult survivors of childhood cancer. Pain status and opioid/marijuana were self-reported at baseline and follow-up evaluation (mean interval = 4.2?years). Over time, 18.7% of survivors endorsed pers ...

Article GUID: 33409451


Using Models to (Re-)Design Synthetic Circuits.

Author(s): McCallum G, Potvin-Trottier L

Mathematical models play an important role in the design of synthetic gene circuits, by guiding the choice of biological components and their assembly into novel gene networks. Here, we present a guide for biologists to build and utilize models of gene networks (synthetic or natural) to analyze dynamical properties of these networks while considering th ...

Article GUID: 33405217


Behavioral weight management interventions in metabolic and bariatric surgery: A systematic review and meta-analysis investigating optimal delivery timing.

Author(s): Julien CA, Lavoie KL, Ribeiro PAB, Dragomir AI, Mercier LA, Garneau PY, Pescarus R, Bacon SL

Metabolic and bariatric surgery (MBS) yields unprecedented clinical outcomes, though variability is high in weight change and health benefits. Behavioral weight management (BWM) interventions may optimize MBS outcomes. However, there is a lack of an evidence base to inform their use in practice ...

Article GUID: 33403754


Assessing the impact of COVID-19 pandemic on urban transportation and air quality in Canada.

Author(s): Tian X, An C, Chen Z, Tian Z

The global outbreak and spread of COVID-19 had a significant impact on the environment of urban areas. This study aimed to provide a new insight into the urban transportation and air pollutant emission of representative Canadian cities impacted by this pandemic. The consumption of urban transportation fuel was analyzed and the corresponding CO2 emission ...

Article GUID: 33401062


Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and cognitive ability in early childhood.

Author(s): Azar N, Booij L, Muckle G, Arbuckle TE, Séguin JR, Asztalos E, Fraser WD, Lanphear BP, Bouchard MF

BACKGROUND: Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with adverse neurodevelopmental outcomes in children, but evidence remains mixed regarding sex differences in this association. OBJECTIVE: To examine the prospective association between prenatal PBDE exp ...

Article GUID: 33395941


Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.

Author(s): DuBois JM, Mathotaarachchi S, Rousset OG, Sziklas V, Sepulcre J, Guiot MC, Hall JA, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E

To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [11C]ABP688 PET binding potentials (BPND), which allows for quantification of mGluR5 availability. Undirect ...

Article GUID: 33401137


Moderate to Substantial Inter-Rater Reliability in the Assessment of Cranial Bone Mobility Restrictions.

Author(s): Demers K, Morin C, Collette L, DeMont R

Background: The World Health Organization benchmarks for osteopathic training consider cranial osteopathy as an important manual skill. Studies of cranial manual therapy have exhibited poor reliability. The aim of this study was to investigate the inter-rater reliability of the manual mobility tests of the spheno-occipital synchondrosis (SOS), and the t ...

Article GUID: 33395535


Naïve Theories of Biology, Physics, and Psychology in Children with ASD.

Author(s): Poulin-Dubois D, Dutemple E, Burnside K

Theory of mind is defined as the understanding that mental states predict and explain people's behaviors. It develops around the age of 4 but seems to remain deficient in people with ASD, whereas other forms of naïve understanding remain intact. This study compares children with ASD to neurotypical children on tasks measuring naïve psychology, physi ...

Article GUID: 33385282


A person-centered perspective on the factors associated with the work recovery process.

Author(s): Gillet N, Morin AJS, Mokounkolo R, Réveillère C, Fouquereau E

BACKGROUND AND OBJECTIVES: This research identified profiles characterized by distinct levels of overcommitment, rumination, psychological detachment (Studies 1 and 2), and need for recovery (Study 2). This research also considers the role of hindrance demands and resources in the prediction of profile membership, and the outcomes of these profiles. MET ...

Article GUID: 33380222


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