Author(s): Keenan ME, Loew M, Berlin KS, Hodges J, Alberts NM, Hankins JS, Porter JS
OBJECTIVE: Determining how the health-related quality of life (HRQOL) is impacted by living with Sickle Cell Disease (SCD) can inform psychosocial interventions. The purpose of the present study is to determine if demographic and treatment variables predict membership into empirically derived subgroups of HRQOL among youth and young adults with SCD. MET ...
Article GUID: 33249456
Author(s): Hamid L; Habboush N; Stern P; Japaridze N; Aydin Ü; Wolters CH; Claussen JC; Heute U; Stephani U; Galka A; Siniatchkin M;
Background and objective: The human brain displays rich and complex patterns of interaction within and among brain networks that involve both cortical and subcortical brain regions. Due to the limited spatial resolution of surface electroencephalography (EEG), EEG source imaging is used to reco ...
Article GUID: 33250282
Author(s): Ferland MC, Therrien-Blanchet JM, Proulx S, Klees-Themens G, Bacon BA, Vu TTD, Théoret H
This study aimed at better understanding the neurochemistry underlying TMS and MRS measurements as it pertains to GABAergic activity following administration of allosteric GABAA receptor agonist lorazepam. Seventeen healthy adults (8 females, 26.0 ± 5.4 years old) participated in a double-blind, crossover, placebo-controlled study, where participants un ...
Article GUID: 33246064
Author(s): Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;
Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatoni ...
Article GUID: 33238462
Author(s): Lévesque M; Gao H; Southward C; Langlois JMP; Léna C; Courtemanche R;
Oscillations in the granule cell layer (GCL) of the cerebellar cortex have been related to behavior and could facilitate communication with the cerebral cortex. These local field potential (LFP) oscillations, strong at 4-12 Hz in the rodent cerebellar cortex during awake immobility, should also be an indicator of an underlying influence on the patterns ...
Article GUID: 33240052
Author(s): González Cautela BV; Quintana GR; Akerman J; Pfaus JG;
RATIONALE: Sexual side effects of chronic treatment with selective serotonin reuptake inhibitors (SSRIs) in humans include anorgasmia and loss of sexual desire and/or arousal which interferes with treatment compliance. There are few options at present to reduce these effects. Because orgasm and desire are mediated in part by activation of sympathetic ar ...
Article GUID: 33242109
Author(s): Ebadi A; Xi P; Tremblay S; Spencer B; Pall R; Wong A;
The outbreak of the novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been continuously affecting human lives and communities around the world in many ways, from cities under lockdown to new social experiences. Although in most cases COVID-19 results in mild illness, it has drawn gl ...
Article GUID: 33230352
Author(s): Smolak E; Hendrickson K; Zesiger P; Poulin-Dubois D; Friend M;
Early vocabulary knowledge and speed of word processing are important foundational skills for the development of preschool and school-age language and cognition. However, the variance in outcomes accounted for by parent-reported receptive or expressive vocabulary is generally modest. Recent research suggests that directly assessed, decontextualized voca ...
Article GUID: 33221662
Author(s): Gad Saad
Many detractors of evolutionary psychology (EP) presume that adaptive arguments are nothing more than whimsical and unfalsifiable just-so stories. The reality though is that the epistemology of EP is precisely the opposite of this antiquated canard in that it fixes the evidentiary threshold much higher than is typically achieved by most scientists. EP a ...
Article GUID: 33224071
Author(s): Kirkpatrick RH; Munoz DP; Khalid-Khan S; Booij L;
Over the past decade, psychiatric research has been on an important hunt for biomarkers of psychiatric disease. In psychiatry, the term "biomarker" is a broad umbrella term used to identify any biological variable that can be objectively measured and applied to a diagnosis; this includes genetic and epigenetic assessments, hormone levels, measures of ne ...
Article GUID: 33221025
Author(s): Chisholm A; Rizzo D; Fortin É; Moman V; Quietshat N; Romano A; Capolicchio T; Shalev U;
Drug addiction is a chronic disorder characterized by compulsive drug seeking and involves repetitive cycles of compulsive drug use, abstinence, and relapse. In both human and animal models of addiction, chronic food restriction increases rates of relapse. Our laboratory has reported a robust increase in drug-seeking following a period of withdrawal in ...
Article GUID: 33219004
Author(s): Aslani N; Kuzgunkaya O; Vidyarthi N; Terekhov D;
Tactical capacity planning is a key element of planning and control decisions in healthcare settings, focusing on the medium-term allocation of a clinic's resources to appointments of different types. One of the most scarce resources in healthcare is physician time. Due to uncertainty in demand for appointments, it is difficult to provide an exact m ...
Article GUID: 33215335
