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A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity

Author(s): Pierre Bikorimana J; Caveney NA; El-Hachem N; Mandl GA; Capobianco JA; Stanga D; Abusarah J; Hancock MA; Farah R; Gonçalves MP; Falzarano D; Liao M; Hamonic G; Liu Q; Beaudoin S; Talbot S; Rafei M;

Despite the recent control of COVID-19, the devastating effects caused by the 3-year pandemic highlight the importance of developing effective vaccines to rapidly address future outbreaks. The present study describes a novel Spike (Sp) protein-based vaccine formulation using the Accum platform. A ...

Article GUID: 41054531


Pseudocapacitive MXene@Fe-TA ternary mediator enhances denitrification via optimized electron transfer and microbial regulation in wastewater treatment

Author(s): Pan S; Wang X; Guo T; An H; Guo Y; Chen Z; Lian J; Guo J;

Inefficient electron transfer is one of the main challenges in practical denitrification applications. To address this issue, a novel ternary mediator functional material (Mxene@Fe-TA) was successfully synthesized, which exhibited pseudocapacitive properties to facilitate electron mediation and distribution. Batch experiments revealed that 50 mg/L MXene@F ...

Article GUID: 41043789


Understanding COVID-19 vaccination disparity among Black adults in North America: A two-study motivational approach

Author(s): Fang X; Holding AC; Audet ÉC; Thai H; Koestner R;

Previous research has revealed lower vaccination rates among Black communities relative to other racial-ethnic communities in North America. However, there remains a gap in understanding the motivational barriers contributing to these persistent disparities. Grounded in Self-Determination Theory, the current research aimed to examine the effects of differ ...

Article GUID: 41043306


A year of nouns from English-learning infants daily lives: The SEEDLingS-Nouns dataset

Author(s): Kalenkovich E; Koorathota S; Tor S; Amatuni A; Egan-Dailey S; Moore C; Laing C; Garrison H; Baudet G; Bulgarelli F; Uner S; Righter L; Bergelson E;

This paper describes a dataset consisting of manually annotated nouns from a corpus of longitudinal day-long audio and hour-long video recordings collected monthly from 44 babies from age 6 months to age 17 months. This dataset was created as part of a larger project, called SEEDLingS, that exami ...

Article GUID: 41034519


Mapping the distribution of contaminants identified by non-targeted screening of passively sampled urban air

Author(s): Liu L; Gillet AP; Akiki C; Tian L; Ma Y; Zhang X; Bowman DT; Wania F; Delbès G; Apparicio P; Bayen S;

Air pollution is closely associated with increased lung cancer incidence and mortality. Because many semi-volatile industrial chemicals, pesticides and combustion by-products are endocrine-disrupting or genotoxic, their mixtures in outdoor urban air, even at trace levels, could have cumulative ef ...

Article GUID: 41033295


Auditory Training for Everyday Functioning in Later Life

Author(s): Li KZH; Campos J; Pichora-Fuller MK;

Following from the World Health Organization's consideration of multiple systems (e.g., sensory, motor, and cognitive) in defining healthy aging, this study presents a review of research on training that has the primary goal of improving complex multitasking outcomes that approximate the everyday contexts in which hearing is important, whether or not ...

Article GUID: 41036263


Correction: Miniaturized scalable arrayed CRISPR screening in primary cells enables discovery at the single donor resolution

Author(s): Patel MA; Boribong BP; Sinha H; Xiao B; Xie K; Vo PQN; Chin AB; Ellouzi A; Little SR; Shih SCC; Wu H; Muller WJ; Hirukawa A;

Article GUID: 41028230


The legality of weight discrimination in Canada: an environmental scan of case law and the limits of Canadian legislation

Author(s): Nutter S; Waugh R; McEachran E; Toor A; Shelley J; Alberga AS; Forhan M; Kirk SF; Nagpal TS; Patton I; Ramos Salas X; Russell-Mayhew S;

Weight stigma negatively impacts people with higher weights across the lifespan as well as social contexts and can lead to weight discrimination. As weight is not a protected identity in Canadian human rights legislation, it is important to better understand how weight discrimination is being arg ...

Article GUID: 41029703


The PREVENT-AD cohort: Accelerating Alzheimer s disease research and treatment in Canada and beyond

Author(s): Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Fajardo Valdez A; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Stri ...

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now be ...

Article GUID: 41020412


Comparative Advances in Sulfide and Halide Electrolytes for Commercialization of All-Solid-State Lithium Batteries

Author(s): Bouguern MD; Ningappa NG; Vishweswariah K; Kumar M R A; Kanno R; Zaghib K;

All-solid-state lithium batteries (ASSBs) outperform lithium-ion batteries (LIBs) in safety, energy density, and thermal stability. Their performance depends on high ionic conductivity, chemical/physical stability, and scalable manufacture of solid electrolytes (SEs). This study compares sulfide- and halide-based SEs, two promising next-generation energy ...

Article GUID: 41017218


Anion Exchange Ionomer Binders for Alkaline Fuel Cells

Author(s): Gowling AC; Meek KM;

Anion exchange ionomer (AEI) binders are critical to the performance of alkaline electrochemical devices (i.e., fuel cells, electrolyzers, and batteries), as they facilitate ion transport, provide structural integrity, and improve the overall performance and lifespan of these devices. These binders not only ensure ion transport but also provide mechanical ...

Article GUID: 41010197


Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles

Author(s): Rattray GF; Jourde HR; Baillet S; Coffey EBJ;

Subcortical brain regions like the thalamus are integral to numerous sensory and cognitive functions. Magnetoencephalography (MEG) enables the study of widespread brain networks with high temporal resolution, but the degree to which deep sources like the thalamus can be resolved remains unclear. Functional connectivity methods may enhance differentiation, ...

Article GUID: 41002111


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