Author(s): Jobin B; Phillips NA; Frasnelli J; Boller B;

BackgroundOlfactory identification decline is a known early marker of Alzheimer's disease and is already present at the mild cognitive impairment (MCI) stage. While being linked with episodic memory, its predictive value for cognitive performance and distinguishing between clinical stages remains unclear.ObjectiveThis study examined (1) the predictive ...

Article GUID: 40944318

Author(s): Rabouhi N; Guindon S; Coleman EA; van Heesbeen HJ; Greenwood CMT; Lu T; Campeau PM;

Chromodomain Helicase DNA-binding (CHD) proteins compose a family of chromatin remodelers that play crucial roles in DNA repair and gene expression regulation, neural stem cell differentiation and chromatin integrity. Genetic variants in CHD chromatin remodelers are associated with neurodevelopmental disorders with features like autism spectrum disorder a ...

Article GUID: 40907936

Author(s): Dufour R; Breton É; Côté SM; Dubois L; Vitaro F; Boivin M; Tremblay RE; Booij L;

Objective: Several studies have shown that maladaptive eating behaviors in childhood predict greater risk for eating disorders in adolescence. Whether or not maladaptive eating behaviors could represent developmental risk factors for a larger spectrum of psychopathologies is unknown. This study described longitudinal trajectories of overeating and picky e ...

Article GUID: 40883733

Author(s): Semper C; Pham TTM; Ram S; Palys S; Evdokias G; Ouedraogo JP; Moisan MC; Geoffrion N; Reid I; Di Falco M; Bailey Z; Tsang A; Benoit-Gelber I; Savchenko A;

Genomics analysis confirmed the status of filamentous fungi as a rich source of novel secondary metabolites; however, the discovery of these compounds is hampered by the cryptic nature of their biosynthetic pathways under laboratory conditions. Consequently, despite substantial research effort ov ...

Article GUID: 40852424

Author(s): Abicumaran Uthamacumaran

Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...

Article GUID: 40848317

Author(s): Yang Z; Chen Z; Lee K;

Amid growing concerns about oil spills in vulnerable Arctic and sub-Arctic regions driven by climate-induced ice retreat, this study presents the development and validation of the OSMT-ice model, an enhanced oil spill modeling system designed to predict the movement and fate of oil in ice-covered waters. The model incorporates ice-concentration-based (ICB ...

Article GUID: 40845360

Author(s): Ali HM; Xiao Y; Kersten-Oertel M;

Hyperspectral imaging (HSI) is a technique that captures and processes information across a wide spectrum of wavelengths, providing detailed spectral data for each pixel in an image to identify and analyze materials or objects. In the surgical domain, it can provide quantitative and qualitative tissue information without the need of any contrast agent, th ...

Article GUID: 40824764

Author(s): Chowdhury R; Karimi N; Xu X; An C; Gitifar A; Ng KTW;

This study analyzes pesticide and fertilizer container collection trends across Canadian agricultural regions over a seven-year period from 2016 to 2022 through an analytical framework and proposed two land metrics. A 28.3 % decrease in the collection of small empty pesticide and fertilizer containers (EPFCs) coincides with a 41.4 % increase in the collec ...

Article GUID: 40795518

Author(s): Richmond IC; Paulauskas MA; Padvaiskas E; Gonzàlez Sinisterra LC; Hutt-Taylor K; Robitaille AL; Ziter CD;

Cities are temporally dynamic ecosystems that experience continuous redevelopment over time. Urban parks, which provide critical benefits to resident wellbeing, are developed on different land-use types and contain natural elements that are susceptible to the effects of historical decision-making ...

Article GUID: 40761092

Author(s): Schousboe JT; Monchka BA; Davidson JM; Kimelman D; Gilani SZ; Ilyas Z; Reid S; Lewis JR; Leslie WD;

Background: It is unknown if prevalent vertebral fracture (PVFx) captured on bone density vertebral fracture assessment (VFA) images predicts incident CVD events. Methods: 11,760 individuals (mean [SD] age 75.7 [6.8] years, 94 % female) had VFA contemporaneously with bone densitometry in Manitob ...

Article GUID: 40759230

Author(s): Usypchuk AA; Maes EJP; Lozzi M; Avramidis DK; Schoenbaum G; Esber GR; Gardner MPH; Iordanova MD;

The discovery that midbrain dopamine (DA) transients can be mapped onto reward prediction errors (RPEs), the critical signal that drives learning, is a landmark in neuroscience. Causal support for the RPE hypothesis comes from studies showing that stimulating DA neurons can drive learning under c ...

Article GUID: 40738112