Author(s): Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ;

Introduction: Cancers often drive T cells toward an exhausted state characterized by impaired cytotoxicity and upregulation of inhibitory receptors (PD-1, TIM-3, CD38) and transcriptional regulators (TOX, NFATc1). Repeated stimulation in vitro is used to model this process, reflecting chronic antigen exposure in the tumor microenvironment. Stress-derived ...

Article GUID: 41906691

Author(s): Fukue M; Lechowicz Z; Mulligan CN; Takeuchi S; Takeuchi H;

As a response to aging of cultured urease-producing microorganisms, the blending method was examined to obtain the required carbonate production amount using the apparent viability (Rcv) based on previous research. As a result, a significantly higher carbonate content than the amount of CaCl2 2H2O used was produced. Since this trend has been obtained in p ...

Article GUID: 41900613

Author(s): Brodeur M; Fortier MÈ; Carrier N; Audette-Chapdelaine S; Auger AM; Savard AC; Kairouz S;

Objectives: This article presents the quantitative phase of a two-phase mixed methods study. The main objective of this article is to examine how the COVID-19 pandemic affected adult gamblers' gambling behaviours and mental health in Quebec. Design: A cross-sectional online survey was used to collect data. Setting: Quebec (Canada). Participants: A ...

Article GUID: 41887629

Author(s): Brushett A; Seguin K; Wong L; McCarry-Taillefer C; Rosenbaum P; Packham T; Campbell W;

Children and youth with disabilities continue to face barriers to accessing quality education, despite education being a key social determinant of health. School-based rehabilitation services (SBRS) include occupational therapy (OT), physiotherapy (PT), and speech-language pathology (SLP) that are delivered within the school context to address these barri ...

Article GUID: 41835425

Author(s): Wang Z; Chen Z; Sajedi S; Deng S; An C;

Article GUID: 41804291

Author(s): Cheyroux P; Morin AJS; O' Connor RM; Colombat P; Vancappel A; Eltanoukhi R; Gillet N;

This study aims to contribute to an improved dynamic person-centred comprehension of the distinct trajectories of alcohol-related problems observed among first-year nursing students. Data was collected from 2963 first-year nursing students on four occasions over the course of their first semester ...

Article GUID: 41797206

Author(s): Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC;

Introduction: It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). Methods: We conducted a 12-month randomized trial comparing P ...

Article GUID: 41795685

Author(s): Kwok C; Sacco S; Lister NB; Alberga AS; Baur LA; Booij L; Carrière K; Garnett SP; Jebeile H;

Background: Pediatric obesity is associated with co-occurring psychosocial conditions, which may be impacted by obesity treatment. Past systematic reviews have shown positive effects for specific psychosocial outcomes following behavioral interventions. This review aimed to extend these findings ...

Article GUID: 41736559

Author(s): Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH;

Background: Hearing loss is one of the largest potentially modifiable risk factors for dementia and is linked with poor cognitive-motor dual-task performance (e.g., walking while performing a cognitive task). Hearing loss is more prevalent and severe in males, whereas dementia is more prevalent i ...

Article GUID: 41694460

Author(s): Mc Mahon A; Merchant H; Alkhatib S; Khanyari S; Alami T; Sader E; Nachabe J; El-Khoury J; Jabr S;

Longstanding armed conflicts generate distinctive psychological wounds, transforming collective bonds and reconfiguring individuals' perceptions of identity, security, and trust, enduring. The occupied Palestinian territories exemplify this violence, as prolonged occupation has produced deep, ...

Article GUID: 41681124

Author(s): Burcheri AJ; Galvin CR; Piché N; Frett MJ; Alschuler K; Alberts NM;

Introduction: Healthcare provider pain knowledge is critical in surgical settings, where effective pain management plays a key role in the prevention of chronic postsurgical pain. Despite this, little is known about the pain training and knowledge of surgical residents. Objective: To comprehensively assess Canadian surgery residents' knowledge and at ...

Article GUID: 41635476