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Microfluidic Liquid Biopsy Minimally Invasive Cancer Diagnosis by Nano-Plasmonic Label-Free Detection of Extracellular Vesicles: Review

Author(s): Neriya Hegade KP; Bhat RB; Packirisamy M;

Cancer diagnosis requires alternative techniques that allow for early, non-invasive, or minimally invasive identification. Traditional methods, like tissue biopsies, are highly invasive and can be traumatic for patients. Liquid biopsy, a less invasive option, detects cancer biomarkers in body fluids such as blood and urine. However, early-stage cancer oft ...

Article GUID: 40650129


Scapegoated communities, shared struggles: A call for solidarity with people who use drugs and queer and trans people

Author(s): London-Nadeau K; Barborini C; Haines-Saah R; Bazarov M; Bristowe S; Khorkhordina M; Lemay-Gaulin M; Gorka C; Juster RP; D' Alessio H; Chadi N;

Efforts to control, repress, and punish drug use and queer and trans existence are rising as right-wing extremism becomes increasingly mainstream. These connected efforts are seen through the stifling of bodily autonomy and agency using criminal-legal, biomedical and political apparatuses, and ha ...

Article GUID: 40633507


Sequencing of a Dairy Isolate Unlocks em Kluyveromyces marxianus /em as a Host for Lactose Valorization

Author(s): Thornbury M; Knoops A; Summerby-Murray I; Dhaliwal J; Johnson S; Utomo JC; Joshi J; Narcross L; Remondetto G; Pouliot M; Whiteway M; Martin VJJ;

The use of genetically modified nonconventional yeast provides significant potential for the bioeconomy by diversifying the tools available for the development of sustainable and novel products. In this study, we sequenced and annotated the genome of Kluyveromyces marxianus Y-1190 to establish it ...

Article GUID: 40629255


Heterologous Expression of Thermostable Endoglucanases from Rasamsonia emersonii: A Paradigm Shift in Biomass Hydrolysis

Author(s): Raheja Y; Singh V; Gaur VK; Tsang A; Chadha BS;

In this study, two thermostable endoglucanases (Rem_GH5EG and Rem_GH7EG) from Rasamsonia emersonii were heterologously expressed in Pichia pastoris and characterized to evaluate their potential for industrial biomass saccharification. Rem_GH5EG demonstrated markedly superior catalytic efficiency toward barley ß-glucan (kcat/Km = 6.3 × 10-3/mg mL/min), whi ...

Article GUID: 40418313


Aquatic exercise versus standard care on paraspinal muscle morphology and function in chronic low back pain patients: a randomized controlled trial

Author(s): Rosenstein B; Montpetit C; Vaillancourt N; Dover G; Weiss C; Papula LA; Melek A; Fortin M;

Low back pain (LBP) is a disabling disease and a public health concern. Aquatic exercise is an alternative form of exercise with less spinal loading and difficulty performing movements, benefiting those with pain-related fear. This study aimed to investigate the effect of an aquatic exercise prog ...

Article GUID: 40328824


Mechanism of Injury and Clinical Recovery Outcomes Following Pediatric Concussion

Author(s): Gudymenko A; Iuliano SG; Gagnon IJ; Iverson GL; Cook NE; Zemek R; Teel EF;

Children with concussion are injured through a variety of mechanisms, but the relationship between mechanism of injury (MOI) and recovery outcomes is unclear due to small sample sizes and varied methodological designs. Our objective was to examine the association of MOI and clinical recovery in youth with concussion using a large dataset collated from a s ...

Article GUID: 40244878


The false promise of return to work for migrant workers injured on the job in Canada: When public policies intersect to create exclusion

Author(s): Hanley J; Ventura Sanchez G; Goswami P; Mayell S; McLaughlin J; Hennebry J;

BackgroundMigrant workers in Canada work in the most dangerous industries, with documented difficulties with occupational health and safety (OHS) and workers' compensation (WC). Little is known, however, about migrant workers' experiences with "return-to-work", the ultimate objective of WC for those who recover from their illness or inju ...

Article GUID: 40223307


Cultural Adaptation and Validation of the Athlete Fear-Avoidance Questionnaire in Arabic: Preliminary Analysis of Fear-Avoidance in ACL-Reconstructed Recreational Players

Author(s): Alanazi R; Kashoo FZ; Alrashdi N; Alanazi S; Shaik AR; Sirajudeen MS; Alenazi A; Nambi G; Dover G; Alanazi AD;

Background: The Athlete Fear-Avoidance Questionnaire (AFAQ) is a validated instrument that measures athletes' fear and avoidance behaviors after an injury, particularly regarding their sporting activities. Purpose: This study aimed to adapt and validate the AFAQ for Arabic-speaking recreatio ...

Article GUID: 40190690


Addressing vaccine hesitancy: A systematic review comparing the efficacy of motivational versus educational interventions on vaccination uptake

Author(s): Labbé S; Bacon SL; Wu N; Ribeiro PAB; Boucher VG; Stojanovic J; Voisard B; Deslauriers F; Tremblay N; Hébert-Auger L; Lavoie KL;

Traditional approaches to increase vaccination rely upon educating patients about vaccines. However, research shows that "knowing" vaccines are important is often insufficient: patients need to believe that getting vaccinated is important. Evidence-based motivational approaches, such as ...

Article GUID: 40167044


Shared Dispersal Patterns but Contrasting Levels of Gene Flow in Two Anadromous Salmonids Along a Broad Subarctic Coastal Gradient

Author(s): Bouchard R; Babin C; Normandeau E; Xuereb A; Boulanger F; Coxon A; Diamond S; Fireman R; Lameboy J; Louttit N; Natawapineskum G; Okimaw D; Torio D; Varty S; Moore JS; Fraser D; Bernatchez L;

Dispersal is a highly variable trait influenced by life history and ecological factors, affecting gene flow when dispersers successfully reproduce. Anadromous salmonids, with their diverse migratory strategies and ecological traits, serve as an ideal model for studying dispersal evolution, showca ...

Article GUID: 40108992


Queer occultism, sentimental biopower, and becoming bottoms as a means to divest from white supremacy among practitioners of magic in Montreal

Author(s): Sydney Sheedy

Astrology, magic, and other psychic healing practices are undergoing a cultural revival, notably among those on the Left who employ it as a language for social justice. Queer practitioners have claimed kinship with the occult through a perceived shared abjection, deeming it an inherently queer resource for self- and community empowerment, and naming anti- ...

Article GUID: 40078317


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