Author(s): Warmerdam CAR; Westra HJ; van der Graaf A; Bonder MJ; Deelen P; van Lieshout T; Landman AJ; Jesse M; Strober BJ; Boltz T; Lapinska S; Nagpal S; Xie M; Tay D; Kirsten H; Naeem H; Raghavan V; Farzeen A; Teumer A; Favé MJ; Persyn E; Tokolyi ...

Many non-coding variants influence complex traits and diseases through gene regulation, yet the mechanisms linking these variants to downstream biology remain poorly understood. Here, we present eQTLGen Phase 2, a comprehensive genome-wide analysis of gene expression quantitative trait loci (eQTL ...

Article GUID: 42051578

Author(s): Korte JA; Steele CJ; Joiner WM; Fan AP;

There is a growing interest to study cerebellar contributions to aging outside of traditional sensory processing and motor tasks. While cerebellar aging analyses typically utilize functional connectivity (FC) to study functional differences with age, this study aimed to identify a marker of healthy aging based on resting state blood oxygenation level depe ...

Article GUID: 42108695

Author(s): Vishweswariah K; Ningappa NG; Kumar M R A; Dawkins JIG; Selva TMG; Zaghib K;

Separators have evolved from passive polymeric barriers into multifunctional components that critically govern the performance, safety, and lifetime of liquid and quasi-solid lithium rechargeable batteries. This Review provides a comprehensive analysis of separator materials and architectures spanning commercial polyolefins and their ceramic coatings, hig ...

Article GUID: 42015518

Author(s): Harsanyi H; Slot N; Parkinson R; Morielli AR; Jeyapalan A; Holmes E; Flynn S; Campbell T; Quan H; Zeng Y; Yang J; Singh S; Vena J; Biddle S; Friedenreich CM; Yang L;

Article GUID: 42015269

Author(s): Côté M; Ramos Salas X; Carrière K; Alberga AS;

Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), are approved for the treatment of type 2 diabetes, obesity, and related conditions, and have demonstrated significant benefits for individuals with these conditions. However, in recent years, public interest and demand for GLP-1RAs-often driven by media, social media ...

Article GUID: 41986775

Author(s): Montpetit C; Vaillancourt N; Rosenstein B; Wesselink EO; Dover G; Weiss C; Papula LA; Melek A; Weber KA; Elliott JM; Fortin M;

Article GUID: 41943153

Author(s): Beaulieu J; Yates MC; Fraser DJ; Cristescu ME; Derry AM;

Anthropogenic activities have led to an unprecedented crisis in freshwater biodiversity loss. The capacity to monitor the abundance of wild populations is critical to conserving biodiversity, but conventional physical specimen collection methods are invasive, costly and labour-intensive. Environmental DNA (eDNA) offers a promising alternative, being easy ...

Article GUID: 41913704

Author(s): Gouin JP; Sánchez-Carro Y; Cruz IP; MacNeil S;

Positive social relationships are linked to better health outcomes. Beyond global evaluations of relationship quality, little is known about how specific interpersonal processes may influence biological pathways promoting optimal health outcomes. Perceived partner responsiveness (PPR) is an interpersonal process through which an individual comes to believ ...

Article GUID: 41876038

Author(s): Brooks M; El Chami R; Jourde HR; Savard MA; Coffey EBJ;

Introduction: Sleep quality is often thought to be a key determinant of cognitive performance, particularly in older adults who experience age-related changes in sleep architecture. However, the extent to which nightly variations in sleep quality impact next-day cognitive performance remains unclear-in part because it has only recently become practical to ...

Article GUID: 41878310

Author(s): Kremin LV; Jardak A; Lew-Williams C; Byers-Heinlein K;

Bilingual children regularly hear sentences that contain words from both languages, also known as code-switching. Investigating how bilinguals process code-switching is a crucial component in understanding bilingual language acquisition, because young bilinguals experience processing costs and reduced comprehension when encountering code-switched nouns. S ...

Article GUID: 41821919

Author(s): Narcross L; Pyne ME; Kevvai K; Siu KH; Dueber JE; Martin VJJ;

The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises >2,500 members, including the pharmaceuticals morphine, codeine, and papaverine, as well as the antibiotics sanguinarine and chelerythrine. Agricultural cultivation can supply the demand for the BIAs that accumulate in plants, but broader access to the BIA family wou ...

Article GUID: 41779670