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Exploiting fluctuations in gene expression to detect causal interactions between genes

Author(s): Joly-Smith E; Talpur MM; Allard P; Papazotos F; Potvin-Trottier L; Hilfinger A;

Characterizing and manipulating cellular behavior requires a mechanistic understanding of the causal interactions between cellular components. We present an approach to detect causal interactions between genes without the need to perturb the physiological state of cells. This approach exploits naturally occurring cell-to-cell variability which is experime ...

Article GUID: 41401079


A type-3 fuzzy synchronization system subjected to hysteresis quantizer inputs and unknown dynamics: Applicable to financial and physical chaotic systems

Author(s): Tian M; Mohammadzadeh A; Taghavifar H; Sakthivel R; Zhang C;

In this paper, a new control approach is proposed for the synchronization and stabilization of a class of chaotic systems with unknown dynamics and input nonlinearities. Type-3 fuzzy logic systems (T3-FLSs) are developed to adaptively model the dynamics of both master and slave systems in real time. The input is affected by sector-bounded hysteresis and q ...

Article GUID: 41381323


A Deep Learning-Based Ensemble System for Brent and WTI Crude Oil Price Analysis and Prediction

Author(s): Zhang Y; Lahmiri S;

Crude oil price forecasting is an important task in energy management and storage. In this regard, deep learning has been applied in the literature to generate accurate forecasts. The main purpose of this study is to design an ensemble prediction system based on various deep learning systems. Specifically, in the first stage of our proposed ensemble syste ...

Article GUID: 41294965


Understanding COVID-19 vaccination disparity among Black adults in North America: A two-study motivational approach

Author(s): Fang X; Holding AC; Audet ÉC; Thai H; Koestner R;

Previous research has revealed lower vaccination rates among Black communities relative to other racial-ethnic communities in North America. However, there remains a gap in understanding the motivational barriers contributing to these persistent disparities. Grounded in Self-Determination Theory, the current research aimed to examine the effects of differ ...

Article GUID: 41043306


How do we know that they actually use it? Exploring measures of adherence to stress management strategies in university students: A systematic review

Author(s): Bastien L; Cho S; Petrovic J; Khoury B; Bloom E; Heath N;

University students are reporting high levels of stress that interfere with their academic performance and daily functioning. In response, higher education institutions have increasingly implemented digital, self-guided stress management resources to provide students with accessible mental health support. While these interventions show promise for improvi ...

Article GUID: 40895119


Deep learning-based feature discovery for decoding phenotypic plasticity in pediatric high-grade gliomas single-cell transcriptomics

Author(s): Abicumaran Uthamacumaran

Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...

Article GUID: 40848317


Distributed adaptive sliding mode control with deep recurrent neural network for cooperative robotic system in automated fiber placement

Author(s): Zhu N; Xie WF;

In this article, a distributed control strategy using an adaptive sliding mode controller (ASMC) is proposed for a 13-degree-of-freedom (13-DOF) cooperative robotic system in the field of automated fiber placement (AFP). A distributed control structure with event-triggered mechanism is developed to guarantee the desired cooperation performance and reduce ...

Article GUID: 40436653


Photocatalytic innovations in PFAS removal: Emerging trends and advances

Author(s): Tabatabaei M; Cho DW; Fahad S; Jeong DW; Hwang JH;

Per- and polyfluoroalkyl substances (PFAS), such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are persistent environmental pollutants posing significant risks to ecosystems, drinking water safety, and human health. Conventional PFAS removal methods effectively mitigate contamination but face challenges such as high operational ...

Article GUID: 40315548


An Effective and Fast Model for Characterization of Cardiac Arrhythmia and Congestive Heart Failure

Author(s): Lahmiri S; Bekiros S;

Background/Objectives: Cardiac arrhythmia (ARR) and congestive heart failure (CHF) are heart diseases that can cause dysfunction of other body organs and possibly death. This paper describes a fast and accurate detection system to distinguish between ARR and normal sinus (NS), and between CHF and NS. Methods: the proposed automatic detection system uses t ...

Article GUID: 40218199


Addressing vaccine hesitancy: A systematic review comparing the efficacy of motivational versus educational interventions on vaccination uptake

Author(s): Labbé S; Bacon SL; Wu N; Ribeiro PAB; Boucher VG; Stojanovic J; Voisard B; Deslauriers F; Tremblay N; Hébert-Auger L; Lavoie KL;

Traditional approaches to increase vaccination rely upon educating patients about vaccines. However, research shows that "knowing" vaccines are important is often insufficient: patients need to believe that getting vaccinated is important. Evidence-based motivational approaches, such as ...

Article GUID: 40167044


Protocol for evaluating neuronal activity and neurotransmitter release following amyloid-beta oligomer injections into the rat hippocampus

Author(s): Hervé V; Bonenfant L; Amyot M; Balafrej R; Ali OBK; Benali H; Brouillette J;

In Alzheimer's disease, there is an imbalance in neurotransmitter release and altered neuronal activation. Here, we present a protocol approach to analyze neuronal activity by combining local field potential (LFP) recording with microdialysis within the same animal. We describe steps for measuring glutamate and GABA levels following hippocampal amyloi ...

Article GUID: 40131934


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