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Exploiting fluctuations in gene expression to detect causal interactions between genes

Author(s): Joly-Smith E; Talpur MM; Allard P; Papazotos F; Potvin-Trottier L; Hilfinger A;

Characterizing and manipulating cellular behavior requires a mechanistic understanding of the causal interactions between cellular components. We present an approach to detect causal interactions between genes without the need to perturb the physiological state of cells. This approach exploits naturally occurring cell-to-cell variability which is experime ...

Article GUID: 41401079


Age estimation via electrocardiogram from smartwatches

Author(s): Adib A; Zhu WP; Ahmad MO;

Age estimation is increasingly vital for regulating access to age-restricted services, especially to protect children online. Traditional methods-ID checks, facial recognition, and databases-raise concerns about privacy and reliability in digital contexts. Electrocardiogram (ECG) signals, reflecting heart activity, offer a promising alternative due to the ...

Article GUID: 41142465


Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

Author(s): Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT;

Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C. albicans can initiate a strong drug tolerance response that allows some cells to ...

Article GUID: 37888959


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