Author(s): Brancheriau CR; Larocque K; Schick G; Tountas I; Perlman A; Piekny A;

Cytokinesis, the final step of cell division, relies on ingression of a precisely positioned actomyosin ring. Chromatin-associated Ran-GTP fine-tunes ring position, although the mechanism remains unclear. We hypothesize that depletion of Ran-GTP between segregating chromosomes leads to equatorial enrichment of importins, promoting recruitment of the sca ...

Article GUID: 42225064

Author(s): Calvano A; Xiao Y; Steidel K; Loehrer PA; Ruppert-Junck MC; Nimsky C; Timmermann L; Bopp MHA; Pedrosa DJ;

Purpose: Accurate segmentation of the subthalamic nucleus (STN) is paramount for optimising outcomes under deep brain stimulation (DBS) in Parkinson's disease (PD). Clinically available tools like Brainlab Elements (BL-E) enable automated segmentations for surgical planning, yet their spati ...

Article GUID: 42225900

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional b ...

Article GUID: 42208339

Author(s): Sander-Montant A; Fibla L; Killam H; Byers-Heinlein K;

A persistent challenge in experimental developmental psychology is determining which of many possible outcome measures best captures underlying behaviors and processes. In the looking-while-listening paradigm for studying early word comprehension, researchers have developed more than 12 distinct outcome measures, but have limited empirical basis for cho ...

Article GUID: 42206598

Author(s): Clayton EJ; Smith-Uffen M; Tribble TW; Duennwald ML; Kohalmi SE;

Background: Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, re ...

Article GUID: 42204708

Author(s): Jain P; Bayerlein C;

eXtended Reality (XR) technologies often embed ableist design assumptions, privileging hand-based interaction and vision-centric interfaces that presume a normative able-bodied user. As a result, many disabled people-including those with limited mobility or blindness-are excluded from the outset, with accessibility added only as an afterthought. We crit ...

Article GUID: 42182821

Author(s): Bonnieux J; Gumuchian ST; Harboun A; Trespalacios F; Bélisle KA; Haddad A; Quintus-Bosz O; McLellan A; Chester-Trudel L; Garred D; Resendes T; Hazel L; Wong SF; Ellenbogen MA;

Intranasal administration of oxytocin has been shown to enhance social cognition and reduce stress reactivity in healthy individuals, suggesting therapeutic potential for mental disorders. However, clinical trials have produced mixed results. Following a systematic search, data were extracted f ...

Article GUID: 42134427

Author(s): Chen EH; Saminathar AJ; Roberts M; Bergdahl A;

Introduction: Falls are a leading cause of hospitalization among older women. While dance classes have gained popularity to reduce the risk of falls, in-person classes may be inaccessible. Online classes provide feasible solutions, but are limited by the lower intensity required by the virtual environment. Blood flow restriction (BFR) provides a safe wa ...

Article GUID: 42132210

Author(s): Wang Z; Huang Y; Zhang G; Wang Z; Chen Z; Mulligan CN; Li SS; Elektorowicz M; Li B; Lee K; An C;

Marine oil spills are one of the most severe anthropogenic threats to oceanic ecosystems, coastal communities, and global economic stability. While traditional monitoring and response approaches have played a foundational role in oil spill management, their effectiveness is often constrained by ...

Article GUID: 42119407

Author(s): Kapasa RL; Grenon C; Berbiche D; Gouin JP; Vena JE; Vasiliadis HM;

Aims: This study identified sex-specific multi-trajectories of anxiety and depression symptoms among Canadians before and during the COVID-19 pandemic, and associated factors according to a public mental health framework for the surveillance of mental health. Methods: Data from 15,021 participants in the Canadian Partnership for Tomorrow's Health c ...

Article GUID: 42107659

Author(s): Reyt M; Adoutoro J; Borgetto F; Desrosiers C; Barbaux L; Gong K; Savard J; Grenier S; Dang Vu TT;

Insomnia and anxiety are highly prevalent and often comorbid in older adults. Although cognitive behavioural therapy is the first-line treatment for insomnia, few interventions simultaneously address both conditions. Furthermore, access remains limited by provider availability and high costs. T ...

Article GUID: 42096653