Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627

Author(s): Su Y; Wang Z; Fu H; Yang A; Chen X; An C;

The 2023 wildfires caused serious riks to air quality and public health across various provinces in Canada, particularly during the period from May to June. This study aims to systematically evaluate the impact of the May-June wildfire events on air pollution in Canada using satellite Aerosol Optical Depth (AOD) data, along with the Hybrid Single-Particle ...

Article GUID: 41520990

Author(s): Spiegler P; Harirpoush A; Xiao Y;

Crucial in disease analysis and surgical planning, manual segmentation of volumetric medical scans (e.g. MRI, CT) is laborious, error-prone, and challenging to master, while fully automatic algorithms can benefit from user feedback. Therefore, with the complementary power of the latest radiological AI foundation models and virtual reality (VR)'s intui ...

Article GUID: 41509996

Author(s): Iuliano SG; Gagnon IJ; Iverson GL; Cook NE; Zemek R; Teel EF;

This secondary analysis examined the association between preexisting mental health conditions and clinical recovery trajectories in adolescents with concussion. Adolescents (13-17; n = 1238) completed clinical assessments (Post-Concussion Symptom Inventory [PCSI] =48 hours postinjury; PCSI/ Pediatric Quality of Life [PedsQL] for 3 months) and were categor ...

Article GUID: 41505351

Author(s): Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ;

Mutations in the TANGO2 gene are associated with a severe neurometabolic disorder in humans, often presenting with life-threatening metabolic crisis. However, the function of TANGO2 protein remains unknown. It has recently been proposed that TANGO2 transports heme within and between cells, from a ...

Article GUID: 41504601

Author(s): Moritz A; Ezzati M; Gélinas Y;

Iron hydroxides play a key role in the preservation of organic matter in soils and sediments, yet the specificity and extent of their interactions with lignin-derived phenols-important source indicators for terrestrial organic matter-remain poorly understood in aquatic systems. In this study, we analyzed surface and downcore sediments along the terrestria ...

Article GUID: 41500137

Author(s): Gheflati B; Mirzaei M; Zuhars J; Rottoo S; Rivaz H;

Purpose: Computer-assisted surgical navigation systems have been developed to improve the precision of total knee arthroplasty (TKA) by providing real-time guidance on implant alignment relative to patient anatomy. However, surface registration remains a key source of error that can propagate through the surgical workflow. This study investigates how pati ...

Article GUID: 41495592

Author(s): Yaghoobian S; An J; Jeong DW; Hwang JH;

Artificial intelligence (AI) and machine learning (ML) are increasingly integrated into Per- and polyfluoroalkyl substances (PFAS) research; however, the field remains fragmented with substantial variation in modeling objectives. This review provides one of the most comprehensive and detailed syntheses to date of AI/ML methods across the PFAS contaminatio ...

Article GUID: 41483514

Author(s): Wang B; Zhao H; Hu X; Shen Y; Li N;

In this study, an innovative adaptive sliding mode fault-tolerant control approach is developed for an over-actuated vertical takeoff and landing (VTOL) fixed-wing unmanned aerial vehicle (UAV) with the capability to suppress overestimation of adaptive parameters. This method is designed to effectively address model uncertainties and actuator faults witho ...

Article GUID: 41475926

Author(s): Hollett KB; Morin AJS; Carrese-Chacra E; Cohen TR; Carbonneau N; Berthiaume MM; Felice E; Gouin JP;

Socioecological models of health view romantic relationships as micro-social systems in which spouses influence one another's health-related thoughts, feelings, and behaviors. Although prior work suggests spousal interdependence in eating behaviors, the degree of interdependence may vary as a ...

Article GUID: 41448461

Author(s): Mosharafian S; Jaeger JAG;

Rapid increases in urban sprawl in many cities across the planet pose a challenge that needs to be addressed urgently. This study proposes targets, limits, and warning values to urban sprawl as a quantitative reference framework for exploring potential future pathways and to provide guidance for future land management. The reference framework serves to ev ...

Article GUID: 41436679