Author(s): Mussa J; Wen L; Sharafi M; Gouin JP; Rahme E; Dasgupta K;

Background: Early cardiovascular disease risk detection opportunities are limited in men, whereas gestational diabetes, gestational hypertension and preeclampsia are risk indicators in women. We hypothesised adverse pregnancy outcomes also signal risk in fathers, due to shared environments and behaviours. Methods: Our retrospective cohort study included ...

Article GUID: 41407531

Author(s): Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H;

Background"Inflammaging" describes chronic low-grade inflammation observed in aging individuals. It may play a major role in neurodegeneration.ObjectiveTo assess blood inflammatory markers in older adults. We hypothesized that elevated inflammation would be found in some cognitively nor ...

Article GUID: 41358624

Author(s): Ge S; Xiao X; Huang B; Britt KC;

Article GUID: 41163714

Author(s): Jobin B; Phillips NA; Frasnelli J; Boller B;

BackgroundOlfactory identification decline is a known early marker of Alzheimer's disease and is already present at the mild cognitive impairment (MCI) stage. While being linked with episodic memory, its predictive value for cognitive performance and distinguishing between clinical stages remains unclear.ObjectiveThis study examined (1) the predictive ...

Article GUID: 40944318

Author(s): Hosseininasabnajar F; Kakinami L;

Loss of brain tissues and cognitive abilities are natural processes of aging, but longitudinal studies are limited. We explored the longitudinal association between global and regional brain measures with cognitive abilities among individuals with normal cognitive status, mild cognitive impairment, and Alzheimer's Disease, including those with stable ...

Article GUID: 40739300

Author(s): Begum A; Uddin MA; Ahsan SM; Islam MA;

Background and aims: The rapid development and deployment of COVID-19 vaccines have been pivotal in the global battle against the pandemic. However, vaccine acceptance remains a critical determinant of their effectiveness. While numerous studies have explored factors influencing vaccine acceptance, there is a notable dearth of research regarding preferenc ...

Article GUID: 40687549

Author(s): Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM;

White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative etiology. Current imaging methods have lacked the specificity to disentangle biological processes ...

Article GUID: 40585093

Author(s): Campbell JR; Russell WA; Wagner CE; Manuel DG; Anipindi V; Baral P; Evans TG; Hankins CA; Sander B;

The Government of Canada, through the COVID-19 Immunity Task Force (CITF), supported over 100 serosurveillance studies during the COVID-19 pandemic, building and strengthening the technical infrastructure necessary for a national serosurveillance network. The value of such a network extends beyon ...

Article GUID: 40588636

Author(s): Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS;

Given the recent deployment of nerve agents as a method of warfare and in targeted assassinations, the development of robust, broad-spectrum medical countermeasures is essential. Our research group has synthesized isatin-pyridine oxime hybrids that have previously demonstrated the ability to resc ...

Article GUID: 40516590

Author(s): Sánchez-Carro Y; Moukarzel M; Friedrich MG; Gouin JP; Luu JM;

Objective: Beyond objective socioeconomic status (SES) indicators, subjective social status (SSS), an individual's subjective perception of their social standing relative to others, has been independently linked to cardiovascular disease (CVD) morbidity and mortality. Some studies also report sex differences in the association between SSS and CVD. Thi ...

Article GUID: 40471966

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519