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Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect"

Author(s): Sun B; Yang JG; Wang Z; Wang Z; Feng W; Li X; Liu SN; Li J; Zhu YQ; Zhang P; Wang W;

Background: The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in-depth research on the selective mechanism of m6A methylation is still lacking. Methods: In this research, meRIP sequencing, mRNA sequencing, meRIP, luciferase ...

Article GUID: 40051055


Neuropsychiatric Symptoms and Psychotropic Medication Use Following SARS-Cov-2 Infection Among Elderly Residents in Long-Term Care Facilities

Author(s): Cruz-Santiago D; Meng X; Canac-Marquis M; Sengupta A; Brassard JP; Pavey E; Girouard H; Vinh DC; Gouin JP;

Background: SARS-CoV-2 infection can lead to persistent post-acute neuropsychiatric symptoms. Older adults with multimorbidity may be at increased risk of post-acute symptoms after COVID-19. The goals of the present study were to assess the associations of SARS-CoV-2 infection with neuropsychiatr ...

Article GUID: 40051588


Unveiling the association between information sources and young adults attitudes and concerns during COVID-19: Results from the iCARE study

Author(s): Tremblay N; Lavoie KL; Bacon SL; Bélanger-Gravel A;

Objectives: Throughout COVID-19, uncertain information on the virus and preventive measures circulated. Young adults, often relying on social rather than traditional media, showed lower adherence to recommendations. This study examines associations between information sources, attitudes toward public health measures and concerns among young adults. Study ...

Article GUID: 40043475


Spatial Variations of Atmospheric Alkylated Polycyclic Aromatic Hydrocarbons across the Western Pacific to the Southern Ocean: Unexpected Increasing Deposition

Author(s): Zhu FJ; Lu XM; Jia JW; Zhang X; Xing DF; Cai MH; Kallenborn R; Li YF; Muir DCG; Zhang ZF; Zhang X;

Spatial variations of atmospheric alkylated polycyclic aromatic hydrocarbons (Alk-PAHs) are key to understanding their long-range atmospheric transport (LRAT). However, limited Alk-PAHs data have hindered their LRAT characterizations on a global scale. In this study, 49 Alk-PAHs were measured in ...

Article GUID: 40025703


Elucidating the toxicity of methyl parathion, imazapic, isoxaflutole, and chlorantraniliprole on human hepatocarcinoma cells and bioinspired membranes

Author(s): Dos Santos DM; Rubira RJG; Salzedas GP; Kobal MB; Moreira LG; Toledo KA; Aoki PHB; DeWolf C; Camacho SA;

Pesticides have boosted agricultural productivity but pose significant risks to environmental and human health. The intensification of agriculture has driven widespread pesticide use, with 66 % of global consumption allocated to sugarcane, soybean and corn. Sugarcane, a major monoculture in Brazi ...

Article GUID: 40020292


Numerical investigation of the flow induced by a transcatheter intra-aortic entrainment pump

Author(s): Park Y; Aycan O; Kadem L;

This study evaluates the fluid dynamics inside and outside transcatheter blood pump positioned in the aorta. We focus on the pump's impact on blood component damage and arterial wall stress. CFD simulations were performed for rotational speeds ranging from 6000 to 15000 rpm, with a blood flow rate of 1.6 L/min. Results show that significant blood dama ...

Article GUID: 40014031


Properties and Behavior of Sandy Soils by a New Interpretation of MICP

Author(s): Fukue M; Lechowicz Z; Mulligan CN; Takeuchi S; Fujimori Y; Emori K;

Research on MICP technology for ground improvement began in the early 2000s, and since then, it has been considered as innovative research. The field of applications is showing signs of expanding from sandy soil stabilization to remediation. However, the research has not always progressed, because it is extremely difficult to evaluate the ability (viabili ...

Article GUID: 40004331


A person-centered examination of adverse childhood experiences and associated distal health, mental health, and behavioral outcomes in the United Arab Emirates

Author(s): Murphy A; Elbarazi I; Horen N; Ismail-Allouche Z; Long T; McNeill A; Arafat C; England D;

Background: An increasing body of evidence highlights the utility of examining adverse childhood experiences (ACEs) utilizing person-centered analytical approaches, particularly for understanding the organization and co-occurrence of ACEs, and their contributions to risk, vulnerability, and the development of intervention efforts. Methods: In the first s ...

Article GUID: 40001056


Genomics-Enabled Mixed-Stock Analysis Uncovers Intraspecific Migratory Complexity and Detects Unsampled Populations in a Harvested Fish

Author(s): Gibelli J; Won H; Michaelides S; Jeon HB; Fraser DJ;

The contributions of distinct populations to annual harvests provide key insights to conservation, especially in migratory species that return to specific reproductive areas. In this context, genetic stock identification (GSI) requires reference samples from source populations to assign harvested individuals, yet sampling might be challenging as reproduct ...

Article GUID: 39995301


5P Risk Classification Predicts Performance on Self-Reported but Not Objective Clinical Outcomes at 4-Weeks Post-Concussion in Children

Author(s): Teel E; Brossard-Racine M; Corbin-Berrigan LA; Gagnon I;

Objective: To determine if performance on symptom, cognitive, balance, fatigue, physical activity, and quality of life outcomes at 4-weeks post-injury in children with concussion differs based on acute 5P risk classification. Design: Prospective cohort. Setting: Laboratory. Patients: Sixty-two children (age: 13.27 ± 2.50 years; 29 (46.7%) females) with ...

Article GUID: 39988038


Physical activity may protect myelin via modulation of high-density lipoprotein

Author(s): Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T;

Introduction: Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied. Methods: We assessed cross-sectionally wh ...

Article GUID: 39989020


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