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MRI as a viable alternative to CT for 3D surgical planning of Cavitary bone tumors

Author(s): Chae Y; Cheers GM; Kim M; Reidler P; Klein A; Fevens T; Holzapfel BM; Mayer-Wagner S;

Cavitary bone defects, defined as a volumetric loss of native bone tissue, require accurate preoperative imaging for treatment planning. While CT (computed tomography) has traditionally been the gold standard for segmentation due to its superior resolution of cortical bone, MRI (magnetic resonance imaging) offers unique advantages, particularly in visuali ...

Article GUID: 40049253


Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect"

Author(s): Sun B; Yang JG; Wang Z; Wang Z; Feng W; Li X; Liu SN; Li J; Zhu YQ; Zhang P; Wang W;

Background: The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in-depth research on the selective mechanism of m6A methylation is still lacking. Methods: In this research, meRIP sequencing, mRNA sequencing, meRIP, luciferase ...

Article GUID: 40051055


Neuropsychiatric Symptoms and Psychotropic Medication Use Following SARS-Cov-2 Infection Among Elderly Residents in Long-Term Care Facilities

Author(s): Cruz-Santiago D; Meng X; Canac-Marquis M; Sengupta A; Brassard JP; Pavey E; Girouard H; Vinh DC; Gouin JP;

Background: SARS-CoV-2 infection can lead to persistent post-acute neuropsychiatric symptoms. Older adults with multimorbidity may be at increased risk of post-acute symptoms after COVID-19. The goals of the present study were to assess the associations of SARS-CoV-2 infection with neuropsychiatr ...

Article GUID: 40051588


A systematic analysis of disability inclusion in domestic climate policies

Author(s): Jodoin S; Bowie-Edwards A; Lofts K; Mangat S; Adjei B; Lesnikowski A;

We provide the first systematic analysis of whether, how, and to what extent people with disabilities and their human rights are included in two subsets of climate policies adopted by 195 parties to the Paris Agreement. We found that only 41 parties mention people with disabilities in their nationally determined contributions (NDCs), whereas only 75 do so ...

Article GUID: 40046455


The neural characteristics influencing literacy outcome in children with cochlear implants

Author(s): Koirala N; Manning J; Neumann S; Anderson C; Deroche MLD; Wolfe J; Pugh K; Landi N; Muthuraman M; Gracco VL;

Early hearing intervention in children with congenital hearing loss is critical for improving auditory development, speech recognition and both expressive and receptive language, which translates into better educational outcomes and quality of life. In children receiving hearing aids or cochlear ...

Article GUID: 40046341


Unveiling the association between information sources and young adults attitudes and concerns during COVID-19: Results from the iCARE study

Author(s): Tremblay N; Lavoie KL; Bacon SL; Bélanger-Gravel A;

Objectives: Throughout COVID-19, uncertain information on the virus and preventive measures circulated. Young adults, often relying on social rather than traditional media, showed lower adherence to recommendations. This study examines associations between information sources, attitudes toward public health measures and concerns among young adults. Study ...

Article GUID: 40043475


The Present and Future of Adult Entertainment: A Content Analysis of AI-Generated Pornography Websites

Author(s): Lapointe VA; Dubé S; Rukhlyadyev S; Kessai T; Lafortune D;

Fueled by advances in artificial intelligence (AI), the adult entertainment industry is undergoing a significant transformation. AI-generated pornography-or AI porn-is reshaping how people create and consume sexually explicit content, progressively offering rapid, mass access to large quantities of interactive and highly customizable experiences. Yet, des ...

Article GUID: 40032709


Spatial Variations of Atmospheric Alkylated Polycyclic Aromatic Hydrocarbons across the Western Pacific to the Southern Ocean: Unexpected Increasing Deposition

Author(s): Zhu FJ; Lu XM; Jia JW; Zhang X; Xing DF; Cai MH; Kallenborn R; Li YF; Muir DCG; Zhang ZF; Zhang X;

Spatial variations of atmospheric alkylated polycyclic aromatic hydrocarbons (Alk-PAHs) are key to understanding their long-range atmospheric transport (LRAT). However, limited Alk-PAHs data have hindered their LRAT characterizations on a global scale. In this study, 49 Alk-PAHs were measured in ...

Article GUID: 40025703


Elucidating the toxicity of methyl parathion, imazapic, isoxaflutole, and chlorantraniliprole on human hepatocarcinoma cells and bioinspired membranes

Author(s): Dos Santos DM; Rubira RJG; Salzedas GP; Kobal MB; Moreira LG; Toledo KA; Aoki PHB; DeWolf C; Camacho SA;

Pesticides have boosted agricultural productivity but pose significant risks to environmental and human health. The intensification of agriculture has driven widespread pesticide use, with 66 % of global consumption allocated to sugarcane, soybean and corn. Sugarcane, a major monoculture in Brazi ...

Article GUID: 40020292


Discriminative properties of rewarding electrical brain stimulation

Author(s): Pacheco-Gomez BL; Zepeda-Ruiz WA; Velazquez-Lopez D; Shizgal P; Velazquez-Martinez DN;

Rewarding electrical brain stimulation (EBS) can serve as a discriminative stimulus. It has long been suspected that this discriminative property reflects the subjective intensity of the rewarding effect. In turn, the counter model of spatiotemporal integration attributes the subjective reward intensity produced by a stimulation train of fixed duration to ...

Article GUID: 40015584


Numerical investigation of the flow induced by a transcatheter intra-aortic entrainment pump

Author(s): Park Y; Aycan O; Kadem L;

This study evaluates the fluid dynamics inside and outside transcatheter blood pump positioned in the aorta. We focus on the pump's impact on blood component damage and arterial wall stress. CFD simulations were performed for rotational speeds ranging from 6000 to 15000 rpm, with a blood flow rate of 1.6 L/min. Results show that significant blood dama ...

Article GUID: 40014031


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