Author(s): Fridgen CPEA; Radomsky AS;

Background and objectives: Beliefs about losing control over one's thoughts, emotions, behaviours, and/or bodily functions have been shown to cause obsessive-compulsive symptoms. The cognitive model of obsessive-compulsive disorder (OCD) suggests that catastrophic misappraisals of intrusions will lessen if underlying maladaptive beliefs are effectivel ...

Article GUID: 39837217

Author(s): Leite ML; Comeau P; Zaghwan A; Shen Y; Manso AP;

Objectives: This study aimed to assess the potential of experimental dental resins containing ZnO nanoparticles (ZnO-NPs) for antimicrobial photodynamic therapy (aPDT) as a functional tool for the modulation of cariogenic biofilm in long-term. Methods: Minimum inhibitory and bactericidal concentrations (MIC/MBC) of ZnO-NPs against Streptococcus mutans we ...

Article GUID: 39765362

Author(s): Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L;

Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understanding of insomnia and its treatment. To date, no study has examined the relationship between K-complexes ...

Article GUID: 39739397

Author(s): Baez A; Singh D; He S; Hajiaghayi M; Gholizadeh F; Darlington PJ; Helfield B;

While met with initial and ground-breaking success targeting blood borne cancers, cellular immunotherapy remains significantly hindered in the context of solid tumors by the tumor microenvironment. Focused ultrasound, in conjunction with microbubbles, has found tremendous potential as a targeted and local drug/gene delivery technique for cancer therapy. T ...

Article GUID: 39502696

Author(s): Garneau J; Savard J; Dang-Vu TT; Gouin JP;

Objective: This study examined whether high frequency heart-rate variability (HF-HRV) and HF-HRV reactivity to worry moderate response to cognitive behavioural therapy for insomnia (CBT-I) within both a standard and stepped-care framework among cancer patients with comorbid insomnia. Biomarkers such as HF-HRV may predict response to CBT-I, a finding which ...

Article GUID: 38991424

Author(s): Singh D; Memari E; He S; Yusefi H; Helfield B;

Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explored as novel non-viral gene delivery vectors for cardiovascular therapy. Given this adaptation to ul ...

Article GUID: 38983873

Author(s): Chien WT; Chong YY; Bressington D; McMaster CW;

This study aimed to test the effectiveness of an acceptance-based medication adherence intervention for people with early-stage psychosis. An assessor-blind, three-arm randomized controlled trial design was used. One hundred and twenty-six participants who were adults with =3 years of psychosis were recruited from four district Integrated Community Center ...

Article GUID: 38908265

Author(s): Morris E; Fitzpatrick MR; Renaud J;

Objective: The present paper attempts to differentiate client involvement from other, similar process variables and presents a pan-theoretical conceptualization of client involvement. Method: A modified Delphi poll was conducted with 20 experienced clinicians and researchers. In two rounds of data collection, the experts completed a questionnaire designe ...

Article GUID: 25017441

Author(s): Gesselman AN; Kaufman EM; Weeks LYS; Moscovici Z; Bennett-Brown M; Adams OR; Campbell JT; Piazza M; Bhuyan L; Dubé S; Hille JJ; Garcia JR;

Objective: The objective of this study is to examine mental health treatment utilization and interest among the large and growing demographic of single adults in the United States, who face unique societal stressors and pressures that may contribute to their heightened need for mental healthcare. ...

Article GUID: 38711766

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM; Ryan S; Raphael S; van Faassen H; Zafer A; Zhu Q; Maclean S; Chattopadhyay A; Gurnani K; Gilber ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains common. Camelid single-domain antibodies (sdAbs or nanobodies) are smaller, simpler, and easier to reco ...

Article GUID: 38596311

Author(s): Ellenbogen MA; Cardoso C; Serravalle L; Vadaga K; Joober R;

Background: Although both pharmacotherapy and psychological treatments are considered to be efficacious in the treatment of major depressive disorder (MDD), one third of patients do not respond to treatment and many experience residual symptoms post-treatment. In this double-blind placebo-controlled randomized control trial (RCT), we assessed whether intr ...

Article GUID: 38445382