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Effect of Saturated Very Long-Chain Fatty Acids on the Organization of Lipid Membranes: A Study Combining (2)H NMR Spectroscopy and Molecular Dynamics Simulations

Author(s): Adrian Paz Ramos

Little is known about the interaction of very long-chain saturated fatty acids (VLCFAs) with biological membranes. However, this could play an important role on interleaflet interactions and signal transduction mechanisms in cells. The aim of this work is t...

Article GUID: 27351151
Title:Effect of Saturated Very Long-Chain Fatty Acids on the Organization of Lipid Membranes: A Study Combining (2)H NMR Spectroscopy and Molecular Dynamics Simulations
Authors:Adrian Paz Ramos
Link:https://pubmed.ncbi.nlm.nih.gov/27351151/
DOI:10.1021/acs.jpcb.6b04958
Category:J Phys Chem B
PMID:27351151
Dept Affiliation: CERMM
1 Department of Chemistry, Université de Montréal , C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada.
2 Institute for Integrative Systems Biology, Department of Biochemistry, Microbiology and Bio-Informatics, Pavillon Alexandre-Vachon, Université Laval , 1045 Avenue de la Médecine, Québec, Québec G1V 0A6, Canada.
3 The Quebec Network for Research on Protein Function, Engineering, and Applications (PROTEO) , 1045 Avenue de la Médecine, Québec, Québec G1V 0A6, Canada.
4 Department of Chemistry and Biochemistry and Centre for Research in Molecular Modeling (CERMM), Concordia University , 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6, Canada.

Description:

Little is known about the interaction of very long-chain saturated fatty acids (VLCFAs) with biological membranes. However, this could play an important role on interleaflet interactions and signal transduction mechanisms in cells. The aim of this work is to determine how VLCFA structurally adapts in fluid phospholipid bilayers, since both species must exhibit a significant hydrophobic mismatch. The membrane organization has been described by means of (2)H NMR and molecular dynamics simulations....