Author(s): Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH;

Background: Hearing loss is one of the largest potentially modifiable risk factors for dementia and is linked with poor cognitive-motor dual-task performance (e.g., walking while performing a cognitive task). Hearing loss is more prevalent and severe in males, whereas dementia is more prevalent i ...

Article GUID: 41694460

Author(s): Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

This study investigated whether higher cardiorespiratory fitness (VO2peak) is associated with better cerebral vascular and metabolic health-specifically cerebral blood flow (CBF), cerebrovascular reactivity (CVR), cerebral metabolic rate of oxygen (CMRO2), and oxygen extraction fraction (OEF) acr ...

Article GUID: 41680492

Author(s): Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain ...

Article GUID: 41543005

Author(s): Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Coronary artery disease (CAD), the leading cause of mortality worldwide, is increasingly recognized for its impact on brain health and cognition, yet the mechanisms linking CAD to vascular and metabolic alterations in the brain remain poorly understood. Prior work has identified regional deficits ...

Article GUID: 41452711

Author(s): Mancor E; Montero-Odasso M; Bherer L; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Li K;

Background: Cognitive and motor deficits have been found to be important markers of Mild Cognitive Impairment (MCI), a pre-dementia risk state. Recently, aerobic exercise (AE) and cognitive training (CT) interventions significantly improved cognitive and motor function in older adults with MCI. R ...

Article GUID: 41448628

Author(s): Gagnon C; Montero-Odasso M; Zou G; Speechley MR; Almeida QJ; Liu-Ambrose T; Middleton LE; Camicioli R; Bray NW; Li K; Fraser S; Pieruccini-Faria F; Burhan AM; Berryman N; Lussier M; Son S; Shoemaker JK; Bherer L;

Background: In recent years, many studies have investigated the effects of non-pharmacological interventions (e.g. physical and cognitive training) on cognition in patients with mild cognitive impairment. The SYNERGIC trial showed that combining physical exercise and cognitive training leads to g ...

Article GUID: 41447475

Author(s): Pieruccini-Faria F; Son S; Liu-Ambrose T; Burhan AM; Almeida QJ; Middleton LE; Li K; Fraser S; Bherer L; Montero-Odasso M;

Background: Mild Cognitive Impairment (MCI) may be associated with the presence of the apolipoprotein E4 allele (APOE4), a genetic factor linked to accelerated cognitive decline. The SYNERGIC trial demonstrated that physical exercise (PE) involving aerobic and resistance training improves global ...

Article GUID: 41435121

Author(s): Pieruccini-Faria F; Son S; Zou G; Almeida QJ; Middleton LE; Bray NW; Lussier M; Shoemaker JK; Speechley M; Liu-Ambrose T; Burhan AM; Camicioli R; Li KZH; Fraser S; Berryman N; Bherer L; Montero-Odasso M;

Background: Older adults with mild cognitive impairment (MCI) have a higher risk of gait impairments and falls; yet, the effects of multimodal interventions, including combinations of exercises with cognitive training, on improving their mobility remain unclear. Objectives: To investigate the sy ...

Article GUID: 40966614

Author(s): Tremblay SA; Potvin-Jutras Z; Sabra D; Rezaei A; Sanami S; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Leppert IR; Tardif CL; Steele CJ; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Patients with coronary artery disease (CAD) face an increased risk of cognitive impairment, dementia, and stroke. While white matter (WM) lesions are frequently reported in patients with CAD, the effects on WM microstructure alterations remain largely unknown. We aimed to identify WM microstructu ...

Article GUID: 40829939

Author(s): Bherer L; Vrinceanu T; Dupuy EG; Gayda M; Vincent T; Magnan PO; Mohammadi H; Gauthier C; Gagnon C; Duchesne S; Erickson KI; Gagnon D; Lesage F; Lupien S; Poirier J; Dubé MP; Thorin É; Juneau M; Breton J; Belleville S; Ferland G; Gaudreau ...

Background: Lifestyle factors like exercise and cognitive stimulation might help improve cognitive performance in older adults. However, studies investigating this, reported mixed results. Most of the data supporting the benefit of exercise comes from cross-sectional studies, cohort studies, or s ...

Article GUID: 40625372

Author(s): Delaire É; Vincent T; Cai Z; Machado A; Hugueville L; Schwartz D; Tadel F; Cassani R; Bherer L; Lina JM; Pélégrini-Issac M; Grova C;

Significance: Understanding the brain's complex functions requires multimodal approaches that combine data from various neuroimaging techniques. Functional near-infrared spectroscopy (fNIRS) offers valuable insights into hemodynamic responses, complementing other modalities such as electroenc ...

Article GUID: 40375973