1 Department of Toxicology, Laboratoire de sciences judiciaires et de médecine légale, 1701 rue Parthenais, Montréal, Québec, Canada H2K 3S7.
2 Department of Chemistry & Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montréal, Québec, Canada H4B 1R6.
3 Department of Mathematics, Université de Sherbrooke, 2500 boulevard de l'Université, Sherbrooke, Québec, CanadaJ1K 2R1.
4 Department of Toxicology, Laboratoire de sciences judiciaires et de médecine légale, 1701 rue Parthenais, Montréal, Québec, CanadaH2K 3S7.
5 Department of Chemistry & Biochemistry,Concordia University, 7141 Sherbrooke Street West, Montréal, Québec, CanadaH4B 1R6.

Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control (QC) accuracy, with an error up to 154%. Unfortunately, simple tools to perform this selection and tests to validate the resulting model are lacking. We present a stepwise,...