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Mechanism of the Nitric Oxide Dioxygenase Reaction of Mycobacterium tuberculosis Hemoglobin N

Author(s): Lavinia A Carabet

Many globins convert ^(•)NO to innocuous NO(3)^(-) through their nitric oxide dioxygenase (NOD) activity. Mycobacterium tuberculosis fights the oxidative and nitrosative stress imposed by its host (the toxic effects of O(2)^(•-) and ^(•)NO species and their OONO^(-) and ^(•)NO(2) derivatives) through the action of truncated hemoglobin N (trHbN), which cat ...

Article GUID: 28835102


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