Author(s): Andrade-Gagnon B; Olszewski C; Bawa KK; Hemraz UD; Oh JK;

The rise in global food demand and the loss in crop production by pests highlight the need for efficient pesticide delivery systems. Stimuli-responsive degradation with thermoresponsive polymers is a promising platform that offers the controlled release of pesticides. Here, we report the development of millimeter-sized thermoresponsive beads (m-beads) com ...

Article GUID: 41561011

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627

Author(s): Lokuge ND; Casillas-Popova SN; Singh P; Clermont-Paquette A; Skinner CD; Findlay BL; Naccache R; Oh JK;

Timely and accurate assessment of wounds during the healing process is crucial for proper diagnosis and treatment. Conventional wound dressings lack both real-time monitoring capabilities and active therapeutic functionalities, limiting their effectiveness in dynamic wound environments. Herein, w ...

Article GUID: 40920389

Author(s): Bairagi K; Shamekhi M; Tountas I; Letourneau N; Peslherbe GH; Piekny A; Oh JK;

The development of stimuli-responsive amphiphilic block copolymers and their nanoassemblies/nanogels integrated with degradable covalent chemistry undergoing chemical transitions has been extensively explored as a promising platform for tumor-targeting controlled/enhanced drug delivery. The conjugate aromatic imine bond is unique in responding to acidic p ...

Article GUID: 40637173

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Oh JK;

Well-defined acid-degradable amphiphilic block copolymers (ABPs) and their nanoassemblies labeled with acid-labile groups have been developed for smart drug delivery, exhibiting controlled/enhanced release of therapeutics in tumoral tissues and endo/lysosomes. In general, controlled polymerization techniques, particularly atom transfer radical polymerizat ...

Article GUID: 40614241

Author(s): Casillas-Popova SN; Lokuge ND; Singh P; Cirillo A; Thinphang-Nga A; Skinner CD; Vuckovic D; Findlay BL; Oh JK;

Owing to their high aspect ratio of length to diameter, large surface area, large pore size, and high molecular orientation, electro-spun (e-spun) nanofibrous mats have been explored as effective nanomaterials for various applications, including wound dressings and healing materials. Of particula ...

Article GUID: 40557709

Author(s): Chung YH; Oh JK;

Biosensing technology, which aims to measure and control the signals of biological substances, has recently been developed rapidly due to increasing concerns about health and the environment. Top-down technologies have been used mainly with a focus on reducing the size of biomaterials to the nano-level. However, bottom-up technologies such as self-assembl ...

Article GUID: 39590001

Author(s): Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK;

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompatible poly(vinyl alcohol) (PVA)-based electro-spun (e-spun) nanofibers. However, PVA nanofibers need ...

Article GUID: 38989606

Author(s): Lavertu JD; Bawa KK; Hrapovic S; Fu D; Oh JK; Hemraz UD;

A process employing extrusion was used to produce multicore microcapsules composed of multiple beads. The inner beads were made from ?-carrageenan (?-c), a thermo-responsive linear sulphated polymer whose gelling temperature ranges at 40-60 °C, depending on the concentration of ?-c polymer and the amount of potassium chloride used for gelation. The result ...

Article GUID: 38915334

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK;

Smart nanoassemblies degradable through the cleavage of acid-labile linkages have attracted significant attention because of their biological relevance found in tumor tissues. Despite their high potential to achieve controlled/enhanced drug release, a systematic understanding of structural factors that affect their pH sensitivity remains challenging, part ...

Article GUID: 38499007

Author(s): Pontarelli A; Liu JT; Oh JK; Wilds CJ;

The protocols described in this article provide details regarding the synthesis and characterization of a disulfide containing linker phosphoramidite for terminal functionalization of synthetic oligonucleotides. The linker is first synthesized from 6-mercaptohexanol in two steps and is incorporated at the 5' end of short DNA oligonucleotides using aut ...

Article GUID: 36840706