Author(s): Ellenbogen MA; Serravalle L; Hodgins S; Walker CD; Walker EF;

The offspring of parents with bipolar disorder (OBD) are at high risk for developing affective disorders. Low levels of organization and consistency in the home (parenting structure) is associated with increased behavioral problems and hypothalamic-pituitary-adrenal (HPA) reactivity in the OBD and thus may be an important developmental risk factor. We als ...

Article GUID: 42247738

Author(s): Wang M; Bhagwat N; Cremonesi F; Dugré M; Pfarr JK; d' Angremont E; Dai A; Jahanpour A; Urchs S; Cansiz S; Chambon L; Dinçer AT; Torres J; Vesin M; Pinilla-Monsalve G; Song Y; Vriend C; Jeanson F; Monchi O; van der Werf YD; Lorenzi M ...

Despite growing understanding of the benefits of having Findable, Accessible, Interoperable, and Reusable (FAIR) data, many datasets still cannot be shared. Federated analysis methods can enable multisite studies that do not require the sharing of participant-level information. However, there are ...

Article GUID: 42146517

Author(s): Marsh JD; Silva NCBS; Gill DP; Riggin B; Zou G; Stranges S; Zwarenstein M; Petrella RJ;

Background/objectives: To describe the program-related costs and estimate the cost-effectiveness of Hockey Fans In Training (Hockey FIT), a gender-sensitized lifestyle intervention, over a 1-year period. Subjects/methods: We conducted a pragmatic, cluster randomized trial among men aged 35-65 years with a body mass index =27 kg/m2, in 39 community-based ...

Article GUID: 42209661

Author(s): Warmerdam CAR; Westra HJ; van der Graaf A; Bonder MJ; Deelen P; van Lieshout T; Landman AJ; Jesse M; Strober BJ; Boltz T; Lapinska S; Nagpal S; Xie M; Tay D; Kirsten H; Naeem H; Raghavan V; Farzeen A; Teumer A; Favé MJ; Persyn E; Tokolyi ...

Many non-coding variants influence complex traits and diseases through gene regulation, yet the mechanisms linking these variants to downstream biology remain poorly understood. Here, we present eQTLGen Phase 2, a comprehensive genome-wide analysis of gene expression quantitative trait loci (eQTL ...

Article GUID: 42051578

Author(s): Ruiz-Blais S; Bernardi NF; Intartaglia B; Snow S; Lehmann A;

Singing and vocalization practices are reportedly associated with increased relaxation, better emotional regulation, and enhanced social closeness. Here, we investigate the neural underpinnings of such effects and ask whether they are related to processes linked to the vocalization aspect or are a result of modified breathing patterns. Toning is a form of ...

Article GUID: 42054483

Author(s): Griffith J; Lord JM; Catchen MD; Arce-Plata MI; Blanchet FG; Chandramohan M; Diaz-Corzo MC; Gravel D; Gutiérrez C; Helfenstein IS; Hoban S; Kass JM; Laikre L; Larocque G; Leigh DM; Leung B; Mastretta-Yanes A; Millette KL; Berbeo MAM; Ngu ...

The Convention on Biological Diversity's Kunming-Montreal Global Biodiversity Framework (GBF) sets ambitious goals to protect and restore biodiversity. It includes a monitoring framework that mandates countries to track progress toward these goals using indicators that summarize biodiversity ...

Article GUID: 41971256

Author(s): Smith-Turchyn J; Sinclair S; O' Loughlin E; Innes A; Richardson J; Pillips S; Beauchamp M; Thabane L; Wrosch C; Sabiston CM;

Purpose: To determine the feasibility and effectiveness of two forms of social support (peer and peer plus virtual professional support) on quality of life, feelings of support, and exercise levels in older adult survivors of cancer. Methods: We conducted a pilot randomized controlled trial. Par ...

Article GUID: 41673350

Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; ...

Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD). Tau pathology can be characterized in terms of spatial extent of tauopathy (SEOT) ...

Article GUID: 41512332

Author(s): Borrie MJ; Phillips NA; Best S; Anastasiou-Ventura P; Aydogan T; Beaudoin C; Beuk J; Celotto I; Cole L; Das S; Fogarty J; Fouquet C; Gnassi L; Henri-Bellemare C; Pilon R; Sands J; Stirbu A; Truemner J; Chan S; Tucker A; Gajraj J; Bhangu ...

Background: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) used wide inclusion criteria recruiting participants across the spectrum from normal cognition to cognitive impairment to all types of clinical dementia, including mixed dementia. 1173 participants comprising ...

Article GUID: 41435411

Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; ...

Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD). Tau pathology can be characterized in terms of spatial extent of tauopathy (SEOT) or load using sta ...

Article GUID: 41433447

Author(s): Biglieri S; Ahmed N; Main S; Tupling OL; Vijayakumar R; Boger J; Daum C; Dupuis S; Koch M; Liu L; Lopez K; Mann J; Martin M; McAiney C; Nasir HJ; Nasir N; Pearce B; Weldrick R; Vanderlinden K; Middleton L;

Exclusion, marginalization and stigma remain common experiences for people living with dementia. Dementia capable communities offer a pathway to support the wellbeing of people living with dementia by creating spaces where people living with dementia and their care partners are supported and empo ...

Article GUID: 41432943