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Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner

Author(s): Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ;

Introduction: Cancers often drive T cells toward an exhausted state characterized by impaired cytotoxicity and upregulation of inhibitory receptors (PD-1, TIM-3, CD38) and transcriptional regulators (TOX, NFATc1). Repeated stimulation in vitro is used to model this process, reflecting chronic antigen exposure in the tumor microenvironment. Stress-derived ...

Article GUID: 41906691


Pseudocapacitive MXene@Fe-TA ternary mediator enhances denitrification via optimized electron transfer and microbial regulation in wastewater treatment

Author(s): Pan S; Wang X; Guo T; An H; Guo Y; Chen Z; Lian J; Guo J;

Inefficient electron transfer is one of the main challenges in practical denitrification applications. To address this issue, a novel ternary mediator functional material (Mxene@Fe-TA) was successfully synthesized, which exhibited pseudocapacitive properties to facilitate electron mediation and distribution. Batch experiments revealed that 50 mg/L MXene@F ...

Article GUID: 41043789


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