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Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome

Author(s): Wannaiampikul S; Lee B; Chen J; Prentice KJ; Ayansola R; Xu A; Santosa S; Pantopoulos K; Sweeney G;

Background: Metabolic Syndrome (MetS) presents a global health challenge, characterized by obesity, hypertension, dyslipidemia, and insulin resistance. Despite recognition of the gut microbiome's role in metabolic health, there remains scope for defining association of unique microbes with cl ...

Article GUID: 41794383


Benzylisoquinoline Alkaloid Production in Yeast via Norlaudanosoline Improves Titer, Selectivity, and Yield

Author(s): Narcross L; Pyne ME; Kevvai K; Siu KH; Dueber JE; Martin VJJ;

The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises >2,500 members, including the pharmaceuticals morphine, codeine, and papaverine, as well as the antibiotics sanguinarine and chelerythrine. Agricultural cultivation can supply the demand for the BIAs that accumulate in plants, but broader access to the BIA family wou ...

Article GUID: 41779670


A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

Author(s): McCallum G; Burckhardt JC; He J; Hong A; Potvin-Trottier L; Tropini C;

The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet non-invasive monitoring tools remain limited. Genetically tractable commensals, including Bacteroides thetaiotaomicron, ...

Article GUID: 41610848


Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility

Author(s): Díaz-Muñoz C; Bozzarelli I; Lopera-Maya EA; Belbasis L; Lo Faro V; Camargo Tavares L; Heredia-Fernández F; Di Lorenzo B; Sinha T; Esteban Blanco C; Favé MJ; Awadalla P; Walters RG; Bonfiglio F; Zhernakova A; Sanna S; D' Amato M;

Background: Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. Objective: To identify genes and mechanisms involved in gut motility, providing a foundation for cli ...

Article GUID: 41558814


A synergistic approach to rapid stabilization and immobilization of crude oil-contaminated clayey sand using calcium chloride and sodium silicate

Author(s): Rajaei E; Elektorowicz M; Baker MB;

The immobilization and stabilization of crude oil-contaminated soils pose significant challenges in geotechnical engineering, particularly in clayey matrices prone to hydrocarbon adsorption and structural degradation. This study evaluates a two-step synergistic grouting technique using calcium chloride (CaCl2) and sodium silicate (Na2SiO3) to enhance stre ...

Article GUID: 41391286


A type-3 fuzzy synchronization system subjected to hysteresis quantizer inputs and unknown dynamics: Applicable to financial and physical chaotic systems

Author(s): Tian M; Mohammadzadeh A; Taghavifar H; Sakthivel R; Zhang C;

In this paper, a new control approach is proposed for the synchronization and stabilization of a class of chaotic systems with unknown dynamics and input nonlinearities. Type-3 fuzzy logic systems (T3-FLSs) are developed to adaptively model the dynamics of both master and slave systems in real time. The input is affected by sector-bounded hysteresis and q ...

Article GUID: 41381323


Substituted diphenylamine antioxidants and synthetic phenolic antioxidants in leachate from domestic landfills in China: Occurrence and removal via treatment

Author(s): Zhang LH; Chen F; Zhang XM; Zhang X; Liang B; Bai SS; Zhang ZF; Li YF; Ren NQ;

Substituted diphenylamine antioxidants (SDPAs) and synthetic phenolic antioxidants (SPAs), widely used in rubber and consumer products, pose growing environmental concerns. This study evaluated the occurrence and release of 43 SDPAs and 4 SPAs in raw leachate and treated effluent from 18 municipal landfills across China. Results showed 17 SDPAs and 1 SPA ...

Article GUID: 41270417


First report of synthetic antioxidants in baby wipes: Insights into occurrence, sources, and infant exposure

Author(s): Wang X; Liu W; Wang J; Johannessen C; Zhang X; Xia K; Wu X; Liu Q;

Synthetic antioxidants (SAs), a group of emerging contaminants, have attracted great attention recently due to their widespread environmental occurrence and potential toxicity. Yet, there is a knowledge gap regarding their occurrence and associated infant exposure in baby wipes, one of the most frequently used baby products. Here, we analyzed SAs-includin ...

Article GUID: 41259909


Enhancement of syngas production via plastic gasification in low-concentration CO sub 2 /sub by using spent lithium-ion batteries-derived black mass

Author(s): Cho DW; Han HJ; Hwang JH; Ahn Y; Yu H;

This study investigates the thermochemical and co-thermochemical conversion of black mass (BM), derived from spent lithium-ion batteries, with and without polyethylene (PE) under various atmospheric conditions (N2, 25 % CO2, and 99.999 % CO2) at temperatures ranging from 700 °C to 900 °C. In an inert N2 environment, gas emissions were minimal, while signi ...

Article GUID: 40992313


A novel span and syntax enhanced large language model based framework for fine-grained sentiment analysis

Author(s): Zou H; Wang Y; Huang A;

Fine-grained aspect-based sentiment analysis requires language models to identify aspect entities and the corresponding sentiment information in the input text content. Transformer-based pre-trained large language models have demonstrated remarkable performance on various challenging natural language processing tasks. However, large language models face l ...

Article GUID: 40876298


Dopamine inhibits excitatory synaptic responses in layer I of the rat parasubiculum

Author(s): Carter F; Hobishi H; Chapman CA;

The parasubiculum is a component of the hippocampal formation that projects to the entorhinal cortex and plays an important role in spatial navigation. Dopamine has marked effects on excitatory synaptic transmission in the hippocampus and entorhinal cortex, and the present study investigated the effects of dopamine on evoked field excitatory postsynaptic ...

Article GUID: 40818632


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