Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Nguyen PV; Dang-Vu TT; Forest G; Desjardins S; Forget MF; Vu TT; Nguyen QD; Kouassi E; Desmarais P;

Background: Mirtazapine promotes sleep by blocking serotonin and histaminergic receptors and is often used off-label to treat chronic insomnia. However, its efficacy remains to be demonstrated in a clinical trial. The MIRAGE study aims to determine the efficacy and safety of mirtazapine in older ...

Article GUID: 40135470

Author(s): Patrick Viet-Quoc N; Thien Thanh DV; Philippe L; Sebastien C; Lidia S; Philippe D;

Objective: This systematic review and meta-analysis evaluates the efficacy in improving sleep quality and safety of hypnotics in individuals aged 65 years or older compared to those under 65 years. Methods: MEDLINE, EMBASE, Web of Science, and EBM Reviews were searched for randomized clinical trials comparing hypnotics to the placebo in adults with chron ...

Article GUID: 39603114

Author(s): Linkiewich D; Martinovich VV; Rinaldi CM; Howe N; Gokiert R;

This study evaluated the relationship between parental autonomy support and preschool-aged children's display of autonomy. Specifically, we examined if mothers' and fathers' use of positive guidance, negative control, and responsiveness during parent-child interactions predicted children's autonomous behavior. One hundred families comprise ...

Article GUID: 33691509

Author(s): Turcotte S; Bouchard C; Rousseau J; DeBroux Leduc R; Bier N; Kairy D; Dang-Vu TT; Sarimanukoglu K; Dubé F; Bourgeois Racine C; Rioux C; Shea C; Filiatrault J;

Objective: To identify facilitators and barriers to older adults' participation in telehealth interventions for primary prevention and health promotion. Methods: Relevant articles were searched using keywords in Embase and MEDLINE. Study characteristics, type of telehealth interventions and ...

Article GUID: 38014903

Author(s): Ireland K; Parker A; Foster N; Penhune V;

Measuring musical abilities in childhood can be challenging. When music training and maturation occur simultaneously, it is difficult to separate the effects of specific experience from age-based changes in cognitive and motor abilities. The goal of this study was to develop age-equivalent scores for two measures of musical ability that could be reliably ...

Article GUID: 29674984