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Smart Optogenetics for Real-Time Automated Control of Cardiac Electrical Activity

Author(s): Deng S; Harlaar N; Zhang J; Dekker SO; Kudryashova NN; Zhou H; Bart CI; Jin T; Derevyanko G; van Driel W; Panfilov AV; Poelma RH; de Vries AAF; Zhang G; De Coster T; Pijnappels DA;

Control theory underpins the stabilization of dynamic systems, including cardiac tissue, where disruptions in electrical conduction cause arrhythmias. Current treatments either act rapidly but without precision or deliver targeted interventions that cannot adapt in real time. We present an integr ...

Article GUID: 41684280


An Effective and Fast Model for Characterization of Cardiac Arrhythmia and Congestive Heart Failure

Author(s): Lahmiri S; Bekiros S;

Background/Objectives: Cardiac arrhythmia (ARR) and congestive heart failure (CHF) are heart diseases that can cause dysfunction of other body organs and possibly death. This paper describes a fast and accurate detection system to distinguish between ARR and normal sinus (NS), and between CHF and NS. Methods: the proposed automatic detection system uses t ...

Article GUID: 40218199


The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.

Author(s): Milev MP, Saint-Dic D, Zardoui K, Klopstock T, Law C, Distelmaier F, Sacher M

TANGO2 variants result in a complex disease phenotype consisting of recurrent crisis-induced rhabdomyolysis, encephalopathy, seizures, lactic acidosis, hypoglycemia, and cardiac arrhythmias. Although first described in a fruit fly model as a protein necessary for some aspect of Golgi function and organization, its role in the cell at a fundamental level h ...

Article GUID: 32909282


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