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Organic chemicals of Arctic concern in Russian coastal seas

Author(s): Min XZ; Zhang X; Xie ZY; Nikolaev A; Vorkamp K; Ma JM; Reiersen LO; Li L; Cai MH; Ren NQ; Li YF; Zhang ZF; Kallenborn R; Muir D;

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs an ...

Article GUID: 41571477


Controlling Temozolomide Efficacy by Light-Dependent Inhibition of O sup 6 /sup ‑Methylguanine DNA Methyltransferase

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960


Synthesis and Acidic pH-Responsive Disassembly of Dual-Location Shell-Sheddable/Core-Degradable Block Copolymer Nanoassemblies and Their Controlled Drug Delivery

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627


Engineered iron-sulfur carriers for efficient mixotrophic and sulfur autotrophic denitrification in low carbon to nitrogen ratio municipal wastewater: Mechanisms of biofilm enhancement and electron transfer promotion

Author(s): Yu S; Zhang X; Guo T; Li H; Liu W; Chen Z; Wang X; Ren B; Guo J;

Sulfur autotrophic denitrification (SAD) offers a sustainable solution for nitrogen removal in low carbon to nitrogen ratio (C/N) municipal wastewater, yet its efficiency and startup time pose significant challenges. To overcome these, we developed iron-sulfur-modified carriers (FeS@MC) and integrated them into an in-situ sequencing batch reactor (S-Fe-SB ...

Article GUID: 40712941


Stability of Acetals/Ketals Under Controlled Radical and Ring Opening Polymerization

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Oh JK;

Well-defined acid-degradable amphiphilic block copolymers (ABPs) and their nanoassemblies labeled with acid-labile groups have been developed for smart drug delivery, exhibiting controlled/enhanced release of therapeutics in tumoral tissues and endo/lysosomes. In general, controlled polymerization techniques, particularly atom transfer radical polymerizat ...

Article GUID: 40614241


Upconversion Lanthanide-Based 2D Metal-Organic Frameworks for Multimode Information Encryption

Author(s): Chen J; Xie Y; Yang W; Sun R; Xing F; Mandl GA; Capobianco JA; Sun L;

Luminescent 2D metal-organic frameworks (MOFs) are a class of metal-organic framework materials expanded in a 2D plane, which have a wide range of applications in fields of optoelectronic devices, sensors, and information storage due to their unique layered structure and excellent optical properties. Currently, research on luminescent 2D MOFs mainly focus ...

Article GUID: 40557752


CACTUS: An open dataset and framework for automated Cardiac Assessment and Classification of Ultrasound images using deep transfer learning

Author(s): Elmekki H; Alagha A; Sami H; Spilkin A; Zanuttini AM; Zakeri E; Bentahar J; Kadem L; Xie WF; Pibarot P; Mizouni R; Otrok H; Singh S; Mourad A;

Cardiac ultrasound (US) scanning is one of the most commonly used techniques in cardiology to diagnose the health of the heart and its proper functioning. During a typical US scan, medical professionals take several images of the heart to be classified based on the cardiac views they contain, wit ...

Article GUID: 40107020


Study on the mechanism of regulating micromolar Fe utilization and promoting denitrification by guanosine monophosphate (GMP) based multi-signal functional material Hematin@Fe/GMP

Author(s): Hao Y; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J;

A novel multi-signal functional material consisting of Hematin, Fe, and guanosine monophosphate (GMP) was successfully constructed (Hematin@Fe/GMP) to enhance denitrification efficiency based on the signal network regulation of electron transfer, micromolar Fe utilization, and microbial community. Hematin@Fe/GMP enhanced nitrate reduction rate by 2.33-fol ...

Article GUID: 39657473


Amorphous Cu/Fe nanoparticles with tandem intracellular and extracellular electron capacity for enhancing denitrification performance and recovery of co-contaminant suppressed denitrification

Author(s): Fu J; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J;

In this study, a functionally stable insoluble Cu/Fe nanoparticles (Cu/Fe NPs) were synthesized and applied denitrification with different contaminants. The results showed that 50 mg/L Cu/Fe NPs increased NO3--N reduction rate up to 14.3 mg/(L·h) about 3 folds compared with the control system (4.7 mg/(L·h)), and Cu/Fe NPs exhibited excellent restorative e ...

Article GUID: 39542060


Fe/GMP functional nanomaterial enhancing the denitrification efficiency by bi-signal regulation: Electron transfer and microbial community

Author(s): Hao Y; Guo T; Li H; Liu W; Chen Z; Zhang W; Wang X; Guo J;

A novel functional nanomaterial composed of guanosine monophosphate (GMP) and Fe enhanced denitrification efficiency by regulating electron transfer and microbial community. Fe/GMP enhanced nitrate (NO3-) degradation rates by 3.00-fold in serum vial batch experiments, with a rate constant of 17.39 mg/(L·h) in sequencing batch reactor. Fe/GMP-mediated inte ...

Article GUID: 39326537


High-Resolution Frequency-Domain Spectroscopic and Modeling Studies of Photosystem I (PSI), PSI Mutants and PSI Supercomplexes

Author(s): Zazubovich V; Jankowiak R;

Photosystem I (PSI) is one of the two main pigment-protein complexes where the primary steps of oxygenic photosynthesis take place. This review describes low-temperature frequency-domain experiments (absorption, emission, circular dichroism, resonant and non-resonant hole-burned spectra) and modeling efforts reported for PSI in recent years. In particular ...

Article GUID: 38612659


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