Keyword search (3,124 papers available) |
Author(s): Harvey A.; Mannette J.; Sigall-Boneh R.; Macintyre B.; Parrott M.; Cahill L.; Connors J.; Otley A.; van Limbergen J.; Grant S.;...
Literature on dietary behaviours of the pediatric Crohn's Disease (CD) population and the relationship between dietary intake and CD activity is limited. Three dietary indices were developed an...
Article GUID: 38634640
Author(s): Anstruther M; Sean M; Tétreault P; Fortin M;
Background and Objectives: Previous research has shown associations between atrophy and fatty infiltration of the lumbar paraspinal musculature and low back pain (LBP). However, few studies have examined longitudinal changes in healthy controls and individu...
Article GUID: 38541216
Author(s): Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ;
Multivariate approaches have recently gained in popularity to address the physiological unspecificity of neuroimaging metrics and to better characterize the complexity of biological processes underlying behavior. However, commonly used approaches are biased...
Article GUID: 38463982
Author(s): Rosenstein B; Burdick J; Roussac A; Rye M; Naghdi N; Valentin S; Licka T; Sean M; Tétreault P; Elliott J; Fortin M;...
It remains unclear whether paraspinal muscle fatty infiltration in low back pain (LBP) is i) solely intramuscular, ii) is lying outside the epimysium between the muscle and fascial plane (epimuscul...
Article GUID: 38280825
Author(s): Avigdor T; Abdallah C; Afnan J; Cai Z; Rammal S; Grova C; Frauscher B;
Objective: The use of electrical source imaging (ESI) in assessing the source of interictal epileptic discharges (IEDs) is gaining increasing popularity in presurgical work-up of patients with drug-resistant focal epilepsy. While vigilance affects the abili...
Article GUID: 38217279
Author(s): Ashouri H; Alam NR; Khoobi M; Haghgoo S; Rasouli Z; Gholami M;
The use of conventional gadolinium(Gd)-based contrast agents in magnetic resonance imaging (MRI) poses a significant risk of Nephrogenic Systemic Fibrosis (NSF) syndrome in patients with impaired renal function (grades 4 and 5). To address this issue, a new...
Article GUID: 38215955
Author(s): Jäger AP; Bailey A; Huntenburg JM; Tardif CL; Villringer A; Gauthier CJ; Nikulin V; Bazin PL; Steele CJ;...
Decreased long-range temporal correlations (LRTC) in brain signals can be used to measure cognitive effort during task execution. Here, we examined how learning a motor sequence affects long-range ...
Article GUID: 38124341
Author(s): Rosenstein B; Montpetit C; Vaillancourt N; Dover G; Khalini-Mahani N; Weiss C; Papula LA; Melek A; Fortin M;...
Background: Low back pain (LBP) is one of the most disabling diseases and a major health issue. Despite the evidence of a link between paraspinal and gluteal muscle dysfunction and LBP, it is unkno...
Article GUID: 38110922
Author(s): Prince SA; Lang JJ; de Groh M; Badland H; Barnett A; Littlejohns LB; Brandon NC; Butler GP; Casu G; Cerin E; Colley RC; de Lannoy L; Demchen...
Background: The growth of urban dwelling populations globally has led to rapid increases of research and policy initiatives addressing associations between the built environment an...
Article GUID: 38062460
Title: | White matter microstructural changes in short-term learning of a continuous visuomotor sequence |
Authors: | Tremblay SA, Jäger AT, Huck J, Giacosa C, Beram S, Schneider U, Grahl S, Villringer A, Tardif CL, Bazin PL, Steele CJ, Gauthier CJ, |
Link: | https://pubmed.ncbi.nlm.nih.gov/33885965/ |
DOI: | 10.1007/s00429-021-02267-y |
Category: | |
PMID: | 33885965 |
Dept Affiliation: | PERFORM
1 Department of Physics/PERFORM Center, Concordia University, Montreal, QC, Canada. 2 Montreal Heart Institute, Montreal, QC, Canada. 3 Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. 4 Charite Universitätsmedizin, Charite, Berlin, Germany. 5 Clinic for Cognitive Neurology, Leipzig, Germany. 6 Leipzig University Medical Centre, IFB Adiposity Diseases, Leipzig, Germany. 7 Collaborative Research Centre 1052-A5, University of Leipzig, Leipzig, Germany. 8 Department of Biomedical Engineering, McGill University, Montreal, QC, Canada. 9 Montreal Neurological Institute, Montreal, QC, Canada. 10 Faculty of Social and Behavioral S |
Description: |
Efficient neural transmission is crucial for optimal brain function, yet the plastic potential of white matter (WM) has long been overlooked. Growing evidence now shows that modifications to axons and myelin occur not only as a result of long-term learning, but also after short training periods. Motor sequence learning (MSL), a common paradigm used to study neuroplasticity, occurs in overlapping learning stages and different neural circuits are involved in each stage. However, most studies investigating short-term WM plasticity have used a pre-post design, in which the temporal dynamics of changes across learning stages cannot be assessed. In this study, we used multiple magnetic resonance imaging (MRI) scans at 7 T to investigate changes in WM in a group learning a complex visuomotor sequence (LRN) and in a control group (SMP) performing a simple sequence, for five consecutive days. Consistent with behavioral results, where most improvements occurred between the two first days, structural changes in WM were observed only in the early phase of learning (d1-d2), and in overall learning (d1-d5). In LRNs, WM microstructure was altered in the tracts underlying the primary motor and sensorimotor cortices. Moreover, our structural findings in WM were related to changes in functional connectivity, assessed with resting-state functional MRI data in the same cohort, through analyses in regions of interest (ROIs). Significant changes in WM microstructure were found in a ROI underlying the right supplementary motor area. Together, our findings provide evidence for highly dynamic WM plasticity in the sensorimotor network during short-term MSL. |