Keyword search (3,098 papers available) |
Author(s): Anstruther M; Sean M; Tétreault P; Fortin M;
Background and Objectives: Previous research has shown associations between atrophy and fatty infiltration of the lumbar paraspinal musculature and low back pain (LBP). However, few studies have examined longitudinal changes in healthy controls and individu...
Article GUID: 38541216
Author(s): Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ;
Multivariate approaches have recently gained in popularity to address the physiological unspecificity of neuroimaging metrics and to better characterize the complexity of biological processes underlying behavior. However, commonly used approaches are biased...
Article GUID: 38463982
Author(s): Rosenstein B; Burdick J; Roussac A; Rye M; Naghdi N; Valentin S; Licka T; Sean M; Tétreault P; Elliott J; Fortin M;...
It remains unclear whether paraspinal muscle fatty infiltration in low back pain (LBP) is i) solely intramuscular, ii) is lying outside the epimysium between the muscle and fascial plane (epimuscul...
Article GUID: 38280825
Author(s): Avigdor T; Abdallah C; Afnan J; Cai Z; Rammal S; Grova C; Frauscher B;
Objective: The use of electrical source imaging (ESI) in assessing the source of interictal epileptic discharges (IEDs) is gaining increasing popularity in presurgical work-up of patients with drug-resistant focal epilepsy. While vigilance affects the abili...
Article GUID: 38217279
Author(s): Ashouri H; Alam NR; Khoobi M; Haghgoo S; Rasouli Z; Gholami M;
The use of conventional gadolinium(Gd)-based contrast agents in magnetic resonance imaging (MRI) poses a significant risk of Nephrogenic Systemic Fibrosis (NSF) syndrome in patients with impaired renal function (grades 4 and 5). To address this issue, a new...
Article GUID: 38215955
Author(s): Jäger AP; Bailey A; Huntenburg JM; Tardif CL; Villringer A; Gauthier CJ; Nikulin V; Bazin PL; Steele CJ;...
Decreased long-range temporal correlations (LRTC) in brain signals can be used to measure cognitive effort during task execution. Here, we examined how learning a motor sequence affects long-range ...
Article GUID: 38124341
Author(s): Rosenstein B; Montpetit C; Vaillancourt N; Dover G; Khalini-Mahani N; Weiss C; Papula LA; Melek A; Fortin M;...
Background: Low back pain (LBP) is one of the most disabling diseases and a major health issue. Despite the evidence of a link between paraspinal and gluteal muscle dysfunction and LBP, it is unkno...
Article GUID: 38110922
Author(s): Prince SA; Lang JJ; de Groh M; Badland H; Barnett A; Littlejohns LB; Brandon NC; Butler GP; Casu G; Cerin E; Colley RC; de Lannoy L; Demchen...
Background: The growth of urban dwelling populations globally has led to rapid increases of research and policy initiatives addressing associations between the built environment an...
Article GUID: 38062460
Author(s): Kheirmandparizi M; Gouin JP; Bouchaud CC; Kebbe M; Bergeron C; Madani Civi R; Rhodes RE; Farnesi BC; Bouguila N; Conklin AI; Lear SA; Cohen ...
Dietary self-monitoring is a behaviour change technique used to help elicit and sustain dietary changes over time. Current dietary self-monitoring tools focus primarily on itemizing foods and count...
Article GUID: 38015899
Title: | Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease |
Authors: | Xiao Y, Peters TM, Khan AR, |
Link: | https://pubmed.ncbi.nlm.nih.gov/34106502/ |
DOI: | 10.1002/hbm.25558 |
Category: | |
PMID: | 34106502 |
Dept Affiliation: | PERFORM
1 Department of Computer Science and Software Engineering, Concordia University, Montreal, Canada. 2 PERFORM Centre, Concordia University, Montreal, Canada. 3 Imaging Research Laboratories, Robarts Research Institute, Western University, London, Canada. 4 Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Canada. 5 School of Biomedical Engineering, Western University, London, Canada. 6 The Brain and Mind Institute, Western University, London, Canada. |
Description: |
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by a range of motor and nonmotor symptoms, often with the motor dysfunction initiated unilaterally. Knowledge regarding disease-related alterations in white matter pathways can effectively help improve the understanding of the disease and propose targeted treatment strategies. Microstructural imaging techniques, including diffusion tensor imaging (DTI), allows inspection of white matter integrity to study the pathogenesis of various neurological conditions. Previous voxel-based analyses with DTI measures, such as fractional anisotropy and mean diffusivity have uncovered changes in brain regions that are associated with PD, but the conclusions were inconsistent, partially due to small patient cohorts and the lack of consideration for clinical laterality onset, particularly in early PD. Fixel-based analysis (FBA) is a recent framework that offers tract-specific insights regarding white matter health, but very few FBA studies on PD exist. We present a study that reveals strengthened and weakened white matter integrity that is subject to symptom laterality in a large drug-naïve de novo PD cohort using complementary DTI and FBA measures. The findings suggest that the disease gives rise to tissue degeneration and potential re-organization in the early stage. |