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Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition

Author(s): Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ;

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a m...

Article GUID: 41353310
The Effect of a 10-Week Electromyostimulation Intervention with the StimaWELL 120MTRS System on Multifidus Morphology and Function in Chronic Low Back Pain Patients: A Randomized Controlled Trial

Author(s): Wolfe D; Rosenstein B; Dover G; Boily M; Fortin M;

Background: Chronic low back pain (CLBP) patients present with morphological and functional deficits to the lumbar multifidus. Electromyostimulation (EMS) can be used to improve activation and strength in atrophied skeletal muscle, but its effect on multifi...

Article GUID: 41283552
Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy

Author(s): Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivi...

Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort...

Article GUID: 41258102
Human short-term memory learning based on dynamic glutamate levels and oscillatory activities: concurrent metabolic and electrophysiological studies using event-related functional-MRS and EEG modalities

Author(s): Mohammadi H; Zargaran SJ; Khajehpour H; Adibi I; Rahimiforoushani A; Karimi S; Serej ND; Alam NR;...

Short-term memory (STM) temporarily stores sensory information, critical for synaptic plasticity, memory, and learning, and is regulated by the glutamate-gated NMDA receptor. While the frontal and ...

Article GUID: 41171530
Effects of cognitive-behavioral therapy for insomnia during sedative-hypnotics withdrawal on sleep and cognition in older adults

Author(s): Barbaux L; Cross NE; Perrault AA; Es-Sounni M; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Tannenbaum C; Guimond A; Grenier S; Gou...

Objectives: Our objective was to assess the effect of cognitive-behavioral therapy for insomnia (CBTi) on subjective and objective sleep quality (including sleep spindles) and cogn...

Article GUID: 41092866
Cerebral small vessel disease lesion segmentation methods: A systematic review

Author(s): Phelps J; Singh M; McCreary CR; Dallaire-Théroux C; Stein RG; Potvin-Jutras Z; Guan DX; Wu JD; Metz A; Smith EE;...

Cerebral small vessel disease (CSVD) can manifest as brain lesions visible on magnetic resonance imaging, including white matter hyperintensities (WMH), cerebral microbleeds (CMB), perivascular spa...

Article GUID: 41080650
The legality of weight discrimination in Canada: an environmental scan of case law and the limits of Canadian legislation

Author(s): Nutter S; Waugh R; McEachran E; Toor A; Shelley J; Alberga AS; Forhan M; Kirk SF; Nagpal TS; Patton I; Ramos Salas X; Russell-Mayhew S;...

Weight stigma negatively impacts people with higher weights across the lifespan as well as social contexts and can lead to weight discrimination. As weight is not a protected identity in Canadian h...

Article GUID: 41029703
The PREVENT-AD cohort: Accelerating Alzheimer s disease research and treatment in Canada and beyond

Author(s): Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Fajardo Valdez A; Mohammedi...

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal o...

Article GUID: 41020412
Child and marital stress are associated with a psychophysiological index of self-regulatory capacities among parents of preschool children

Author(s): MacNeil S; da Estrela C; Caldwell W; Gouin JP;

Objective: A parent's ability to self-regulate influences parenting practices. Child-related stressors may deplete parent's self-regulatory capacities. However, this effect may be moderated by the marital context within which stressful parent-child ...

Article GUID: 40972822
Title:Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition
Authors:Potvin-Jutras Z,  Tremblay PL,  Mohammadi H,  Villeneuve S,  Spreng RN,  Gauthier CJ, 
Link:https://pubmed.ncbi.nlm.nih.gov/41353310/
DOI:10.1007/s11357-025-02036-3
Category:
PMID:41353310
Dept Affiliation: SOH
1 Physics Department, Concordia University, 7141 Rue Sherbrooke W, Montréal, Québec, H4B 1R6, Canada.
2 Centre Epic and Research Center, Montreal Heart Institute, 5000 Rue Bélanger, Montréal, Québec, H1T 1C8, Canada.
3 School of Health, Concordia University, 7200 Rue Sherbrooke W, Montréal, Québec, H4B 1R6, Canada.
4 Department of Medicine, Université de Montréal, C. P. 6128, Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada.
5 Department of Psychiatry, McGill University, 845 Rue Sherbrooke W, Montréal, Québec, H3A 0G4, Canada.
6 McConnell Brain Imaging Centre, Montreal Neurological Institute, 845 Rue Sherbrooke W, Montréal, Québec, H3A 0G4, Canada.
7 StoP-AD Centre, Douglas Mental Health Institute Research Centre, 6875 Blvd. LaSalle, Verdun, Québec, H4H 1R3, Canada.
8 Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montréal, Québec, H3A 2B4, Canada.
9 Physics Department, Concordia University, 7141 Rue Sherbrooke W, Montréal, Québec, H4B 1R6, Canada. claudine.gauthier@concordia.ca.
10 Centre Epic and Research Center, Montreal Heart Institute, 5000 Rue Bélanger, Montréal, Québec, H1T 1C8, Canada. claudine.gauthier@concordia.ca.
11 School of Health, Concordia University, 7200 Rue Sherbrooke W, Montréal, Québec, H4B 1R6, Canada. claudine.gauthier@concordia.ca.

Description:

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a marker of vascular stiffness, are sensitive biomarkers of early vascular dysfunction associated with aging and AD. However, the relationship between APOE4 status and these cerebrovascular metrics remains unclear. This study investigated whether the APOE genotype influences longitudinal changes in CVR and CP, and their association with cognitive performance in cognitively unimpaired individuals. We utilized the PREVENT-AD cohort, including 101 APOE4 carriers (30 males and 71 females) and 152 non-APOE4 carriers (48 males and 104 females) aged 55 and older. Relative CVR and CP were derived from resting state functional magnetic resonance imaging data, with regional values extracted from cerebral arterial territories. Results indicated significant interactions between APOE4 status and relative CVR in the left middle cerebral artery and left posterior cerebral artery (PCA) territories. APOE4 status disaggregated analyses revealed that APOE4 carriers uniquely presented a significant decline in relative CVR within the left PCA. Furthermore, sex-specific effects were identified, with female APOE4 carriers having lower relative CVR in the right anterior cerebral artery territory compared to female non-carriers. Importantly, higher relative CVR was positively associated with better cognitive performance in APOE4 carriers. No significant effects of APOE4 status on CP were found. Together, these findings suggest that relative CVR may be an important early measure of cerebrovascular health and cognition in cognitively intact APOE4 carriers.