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Different behavioral measures of conditioned magazine activity can tell different stories about brain function

Author(s): Volz S; Loewinger G; Marquez I; Fevola S; Kang M; Reverte I; Krishnan A; Gardner MPH; Iordanova MD; Esber GR;

Elucidating the neural substrates of Pavlovian reward learning requires reliable behavioral readouts. In conditioned magazine approach studies, rodents express reward expectancy by approaching the food magazine during cues that predict reward. This behavior is typically quantified using one of th ...

Article GUID: 41922165


Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions

Author(s): Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM;

White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative etiology. Current imaging methods have lacked the specificity to disentangle biological processes ...

Article GUID: 41916976


Social exclusion, but not withdrawal, is diminished by a friend s level of acceptance: A provisions model

Author(s): Commisso M; Bukowski WM;

Using the Actor-Partner-Interdependence Model, a friend's level of peer acceptance on the stability of a child's social withdrawal and peer exclusion was assessed with a sample of 252 fifth- and sixth-grade girls and boys of European and North-African descent from lower- and upper-middle class neighborhoods in Montreal, Quebec, in 2015/2016. Socio ...

Article GUID: 41914693


eDNA Provides Accurate Population Abundance Estimates With Bioenergetics and Particle Mass-Balance Modelling

Author(s): Beaulieu J; Yates MC; Fraser DJ; Cristescu ME; Derry AM;

Anthropogenic activities have led to an unprecedented crisis in freshwater biodiversity loss. The capacity to monitor the abundance of wild populations is critical to conserving biodiversity, but conventional physical specimen collection methods are invasive, costly and labour-intensive. Environmental DNA (eDNA) offers a promising alternative, being easy ...

Article GUID: 41913704


Management of brain-heart multimorbidity: a clinical practice guideline

Author(s): Edwards JD; Li Z; McFarlane P; Rabi DM; Gilbert J; Bajaj HS; MacIntosh BJ; Bittman J; Feldman RD; Dresser G; Terenzi K; Swartz R; Gabor J; Pearson GJ; Selby P; Wharton S; Warburton DER; Pakhalé S; Styra R; Baker B; Tu K; Hawkins M; Stone ...

Background: Although brain and heart conditions share overlapping risk factors and commonly co-occur, current cardiac and neurologic clinical guidelines are typically produced within specialty silos. The objective of this guideline from a Canadian Cardiovascular Harmonized National Guideline Ende ...

Article GUID: 41912243


Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner

Author(s): Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ;

Introduction: Cancers often drive T cells toward an exhausted state characterized by impaired cytotoxicity and upregulation of inhibitory receptors (PD-1, TIM-3, CD38) and transcriptional regulators (TOX, NFATc1). Repeated stimulation in vitro is used to model this process, reflecting chronic antigen exposure in the tumor microenvironment. Stress-derived ...

Article GUID: 41906691


Investigating Workplace Bullying Using a Person-Centered Approach: Capturing Targets Exposure and Sense of Defenselessness Through Latent Profile Analysis

Author(s): Trépanier SG; Notelaers G; Birkeland Nielsen M; Morin AJS;

Workplace bullying is conceptualized as a systematic exposure to harassing behavior accompanied by feelings of defenselessness. Yet, most research has solely focused on exposure, thereby ignoring the role of defenselessness regarding victimization from bullying. Using a person-centered approach, this cross-sectional study addresses this gap by investigati ...

Article GUID: 41902650


Sagittal abdominal diameter and abdominal aortic calcification are associated with incident major adverse cardiovascular events: The Manitoba Bone Density Registry

Author(s): Abraha HN; Gebre AK; Sim M; Smith C; Gilani SZ; Ilyas Z; Zarzour F; Schousboe JT; Lix LM; Binkley N; Reid S; Monchka BA; Kimelman D; Lewis JR; Leslie WD;

Background: Sagittal abdominal diameter (SAD), a measure of visceral adiposity, has been linked to major adverse cardiovascular events (MACE). However, the relationship between SAD and abdominal aortic calcification (AAC), a marker of subclinical vascular disease, and whether they independently a ...

Article GUID: 41903786


Regioselective Stepwise Synthesis of Unsymmetrical 1,2,5-Triarylpyrroles via Palladium-Catalyzed Decarboxylative Cross-Coupling and C-H Arylation

Author(s): Buonomano C; Patterson S; Ngou JS; Messina C; Taylor S; Bilodeau F; Forgione P;

Pyrrole derivatives are natural organic molecules that are important to the pharmaceutical industry due to their occurrence in nature and their use in a wide range of medical applications. In general, non-symmetric, 1,2,5-triaryl-substituted pyrroles are prepared either by Paal-Knorr condensation or cycloaddition that present synthetic challenges particul ...

Article GUID: 41900086


Synthesis and Characterization of CNC/CNF/rGO Composite Films for Advanced Functional Applications

Author(s): Ramezani G; Stiharu I; van de Ven TGM; Ramezani H; Nerguizian V;

Developing advanced functional materials requires the synergistic integration of nanoscale reinforcements with tailored properties. In this work, composite films of cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and reduced graphene oxide (rGO) were synthesized using a combination of solution casting, high shear homogenization, vacuum filtra ...

Article GUID: 41900273


Evaluation and Utilization of Aged Bacteria in MICP Technology

Author(s): Fukue M; Lechowicz Z; Mulligan CN; Takeuchi S; Takeuchi H;

As a response to aging of cultured urease-producing microorganisms, the blending method was examined to obtain the required carbonate production amount using the apparent viability (Rcv) based on previous research. As a result, a significantly higher carbonate content than the amount of CaCl2 2H2O used was produced. Since this trend has been obtained in p ...

Article GUID: 41900613


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