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Modulating sleep: slow oscillation and spindle stimulation effects on physiology and memory

Author(s): Jourde HR; Sita KZ; Eyqvelle Z; Brooks M; Coffey EBJ;

Sleep plays a role in memory consolidation, with slow oscillations (SO) and sleep spindles (SP) in non-rapid eye movement sleep being central to this process. While closed-loop auditory stimulation of slow oscillations has been well studied, precise real-time targeting of individual sleep spindles to assess their memory impact has remained technically cha ...

Article GUID: 41559130


Thermo-responsive polysulfobetaine beads crosslinked with biodegradable alginates for controlled release of agricultural pesticide

Author(s): Andrade-Gagnon B; Olszewski C; Bawa KK; Hemraz UD; Oh JK;

The rise in global food demand and the loss in crop production by pests highlight the need for efficient pesticide delivery systems. Stimuli-responsive degradation with thermoresponsive polymers is a promising platform that offers the controlled release of pesticides. Here, we report the development of millimeter-sized thermoresponsive beads (m-beads) com ...

Article GUID: 41561011


Kubo-Martin-Schwinger states of path-structured flow in directed brain synaptic networks

Author(s): Elkaïoum M Moutuou

The brain's synaptic network, characterized by parallel connections and feedback loops, drives interaction pathways between neurons through a large system with infinitely many degrees of freedom. This system is best modeled by the graph C*-algebra of the underlying directed graph, the Toeplitz-Cuntz-Krieger (TCK) algebra, which captures the diversity ...

Article GUID: 41560241


Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility

Author(s): Díaz-Muñoz C; Bozzarelli I; Lopera-Maya EA; Belbasis L; Lo Faro V; Camargo Tavares L; Heredia-Fernández F; Di Lorenzo B; Sinha T; Esteban Blanco C; Favé MJ; Awadalla P; Walters RG; Bonfiglio F; Zhernakova A; Sanna S; D' Amato M;

Background: Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. Objective: To identify genes and mechanisms involved in gut motility, providing a foundation for cli ...

Article GUID: 41558814


Scientists warning: we must change paradigm for a revolution in toxicology and world food supply

Author(s): Seralini GE; Jungers G; Andersen A; Antoniou M; Aschner M; Bacon MH; Bertrand M; Bohn T; Bonfleur ML; Bücking E; Defarge N; Djemil R; Domingo JL; Douzelet J; Fagan J; Fournier T; Garcia JLY; Gil S; Hervé-Gruyer P; Hilbeck A; Hilty L; Hub ...

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petr ...

Article GUID: 41551494


The effect of 14 days Actovegin administration with or without high intensity training on exercise capacity and skeletal muscle mitochondrial respiration

Author(s): Hassø RK; Lindtofte S; Kosik B; Bergdahl A; Larsen S;

Article GUID: 41553522


Measurement invariance and differential item functioning of the Functionality Appreciation Scale (FAS) in five latin american nations

Author(s): Mebarak M; Maïano C; Mendoza J; Chirullo V; Coneo AMC; Compte EJ; Cruz-Licea V; Góngora VC; Henríquez C; Martínez-Banfi M; Mejía Rodriguez DL; Pescetto I; Selma H; Boothroyd LG; Thornborrow T; Todd J; Swami V;

The Functionality Appreciation Scale (FAS) is increasingly used within diverse national and linguistic contexts, but assessments of its functioning across groups remains limited. To extend knowledge, we examined measurement invariance of the FAS across five Latin American nations (Argentina, Chil ...

Article GUID: 41547175


Assessing the performance of a surface washing agent for oil removal from sand in cold environments

Author(s): Sui J; Bi H; Yue R; Fu H; Yang A; An C;

Persistent oil contamination along coastlines can be treated by surface washing agents (SWAs), while low-temperature conditions can significantly impact the effectiveness of SWAs in oil removal. This study investigates the oil removal performance of a commercial SWA for oiled shoreline sand in cold-region environments. Batch oil removal tests were conduct ...

Article GUID: 41544565


Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults

Author(s): Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain ...

Article GUID: 41543005


Controlling Temozolomide Efficacy by Light-Dependent Inhibition of O sup 6 /sup ‑Methylguanine DNA Methyltransferase

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960


The temporal effects of auditory and visual immersion on speech level in virtual environments

Author(s): Zhang XN; Shamei A; Grond F; Verduyckt I; Bouserhal RE;

Speech takes place in physical environments with visual and acoustic properties, yet how these elements and their interaction influence speech production is not fully understood. While a room's appearance can suggest its acoustics, it is unclear whether people adjust their speech based on this visual information. Previous research shows that higher re ...

Article GUID: 41528171


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