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A perspective of emerging trends in integrated PFAS detection and remediation technologies with data driven approaches

Author(s): Yaghoobian S; Ramirez-Ubillus MA; Zhai L; Hwang JH;

Per- and polyfluoroalkyl substances (PFAS) are highly persistent synthetic chemicals that pose severe environmental and health risks, prompting increasingly stringent regulations. The recent crises caused by PFAS contamination underscore the urgent need for rapid, sensitive, and on-site monitoring, along with effective removal and degradation from water s ...

Article GUID: 40656524


Shear Stress and Microbubble-Mediated Modulation of Endothelial Cell Immunobiology

Author(s): Memari E; Singh D; Alkins R; Helfield B;

Cellular immunotherapy remains hindered in the context of solid tumors due to the immunosuppressive microenvironment, in which key endothelial cell adhesion molecules (CAM) are suppressed. Microbubble-mediated focused ultrasound is being explored for targeted immunotherapy and can exert local shear stress upon neighboring endothelial cells. However, fluid ...

Article GUID: 40657183


Microfluidic Liquid Biopsy Minimally Invasive Cancer Diagnosis by Nano-Plasmonic Label-Free Detection of Extracellular Vesicles: Review

Author(s): Neriya Hegade KP; Bhat RB; Packirisamy M;

Cancer diagnosis requires alternative techniques that allow for early, non-invasive, or minimally invasive identification. Traditional methods, like tissue biopsies, are highly invasive and can be traumatic for patients. Liquid biopsy, a less invasive option, detects cancer biomarkers in body fluids such as blood and urine. However, early-stage cancer oft ...

Article GUID: 40650129


Unintended consequences of measuring gestational weight gain: how to reduce weight stigma in perinatal care

Author(s): Alberga AS; Incollingo Rodriguez AC; Nagpal TS;

In this commentary, we discuss how the practice of measuring gestational weight gain may perpetuate weight stigma and resultant discrimination if not thoughtfully assessed. We offer suggestions to reduce the likelihood of weight stigma and discrimination in perinatal care settings.

Article GUID: 40652172


Assessment of cognitive load in the context of neurosurgery

Author(s): Di Giovanni DA; Kersten-Oertel M; Drouin S; Collins DL;

Purpose: Image-guided neurosurgery demands precise depth perception to minimize cognitive burden during intricate navigational tasks. Existing evaluation methods rely heavily on subjective user feedback, which can be biased and inconsistent. This study uses a physiological measure via electroencephalography (EEG), to quantify cognitive load when using nov ...

Article GUID: 40650801


Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults

Author(s): Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;

Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effects of a single dose of lorazepam on brain functional connectivity at rest is not known. In this pla ...

Article GUID: 40646404


Deformable detection transformers for domain adaptable ultrasound localization microscopy with robustness to point spread function variations

Author(s): Gharamaleki SK; Helfield B; Rivaz H;

Super-resolution imaging has emerged as a rapidly advancing field in diagnostic ultrasound. Ultrasound Localization Microscopy (ULM) achieves sub-wavelength precision in microvasculature imaging by tracking gas microbubbles (MBs) flowing through blood vessels. However, MB localization faces challenges due to dynamic point spread functions (PSFs) caused by ...

Article GUID: 40640235


Development of dual acid-visible light-degradable core-crosslinked nanogels with extended conjugate aromatic imines for enhanced drug delivery

Author(s): Bairagi K; Shamekhi M; Tountas I; Letourneau N; Peslherbe GH; Piekny A; Oh JK;

The development of stimuli-responsive amphiphilic block copolymers and their nanoassemblies/nanogels integrated with degradable covalent chemistry undergoing chemical transitions has been extensively explored as a promising platform for tumor-targeting controlled/enhanced drug delivery. The conjugate aromatic imine bond is unique in responding to acidic p ...

Article GUID: 40637173


Scapegoated communities, shared struggles: A call for solidarity with people who use drugs and queer and trans people

Author(s): London-Nadeau K; Barborini C; Haines-Saah R; Bazarov M; Bristowe S; Khorkhordina M; Lemay-Gaulin M; Gorka C; Juster RP; D' Alessio H; Chadi N;

Efforts to control, repress, and punish drug use and queer and trans existence are rising as right-wing extremism becomes increasingly mainstream. These connected efforts are seen through the stifling of bodily autonomy and agency using criminal-legal, biomedical and political apparatuses, and ha ...

Article GUID: 40633507


Inferring concussion history in athletes using pose and ground reaction force estimation and stability analysis of plyometric exercise videos

Author(s): Alves W; Babouras A; Martineau PA; Schutt D; Robbins S; Fevens T;

Concussions present a significant risk to athletes, with females exhibiting higher rates and prolonged recovery times than males. Current sideline concussion detection methods, such as the King-Devick test commonly used as a rapid screening tool designed to evaluate eye movement, attention, language, and cognitive processing abilities suffer from validity ...

Article GUID: 40632382


Sequencing of a Dairy Isolate Unlocks em Kluyveromyces marxianus /em as a Host for Lactose Valorization

Author(s): Thornbury M; Knoops A; Summerby-Murray I; Dhaliwal J; Johnson S; Utomo JC; Joshi J; Narcross L; Remondetto G; Pouliot M; Whiteway M; Martin VJJ;

The use of genetically modified nonconventional yeast provides significant potential for the bioeconomy by diversifying the tools available for the development of sustainable and novel products. In this study, we sequenced and annotated the genome of Kluyveromyces marxianus Y-1190 to establish it ...

Article GUID: 40629255


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