Author(s): Freeman-Cole CE; Jaeger JAG;

While landscape connectivity is an important focus of Canada's conservation goals, Canadian national parks are vulnerable to habitat loss, the breaking-up of habitat patches, and a reduction in their connectivity to surrounding ecosystems. This study measured landscape fragmentation in 43 Canadian national parks and control areas throughout their hist ...

Article GUID: 42228295

Author(s): Abdallah W; Darwish A; Garcia J; Kadem L;

Background: Aortic regurgitation (AR) alters normal blood flow patterns in the left ventricle (LV), affecting diastolic filling dynamics, and is commonly quantified by the regurgitant fraction (RF). However, conventional diagnostic methods have notable limitations, prompting growing interest in four-dimensional flow magnetic resonance imaging (4D-flow MRI ...

Article GUID: 42228301

Author(s): Brancheriau CR; Larocque K; Schick G; Tountas I; Perlman A; Piekny A;

Cytokinesis, the final step of cell division, relies on ingression of a precisely positioned actomyosin ring. Chromatin-associated Ran-GTP fine-tunes ring position, although the mechanism remains unclear. We hypothesize that depletion of Ran-GTP between segregating chromosomes leads to equatorial enrichment of importins, promoting recruitment of the scaff ...

Article GUID: 42225064

Author(s): Calvano A; Xiao Y; Steidel K; Loehrer PA; Ruppert-Junck MC; Nimsky C; Timmermann L; Bopp MHA; Pedrosa DJ;

Purpose: Accurate segmentation of the subthalamic nucleus (STN) is paramount for optimising outcomes under deep brain stimulation (DBS) in Parkinson's disease (PD). Clinically available tools like Brainlab Elements (BL-E) enable automated segmentations for surgical planning, yet their spatial ...

Article GUID: 42225900

Author(s): Fereshteh Mehrabi

CONCLUSIONS: This longitudinal study suggests that frailty progression may play a role in the association between sensory decline and executive function over 6 years, particularly in the context of vision decline. Public health policies targeting (pre)frailty among individuals experiencing sensory decline could promote healthy cognitive aging.

Article GUID: 42223330

Author(s): Wang M; Bhagwat N; Cremonesi F; Dugré M; Pfarr JK; d' Angremont E; Dai A; Jahanpour A; Urchs S; Cansiz S; Chambon L; Dinçer AT; Torres J; Vesin M; Pinilla-Monsalve G; Song Y; Vriend C; Jeanson F; Monchi O; van der Werf YD; Lorenzi M ...

Despite growing understanding of the benefits of having Findable, Accessible, Interoperable, and Reusable (FAIR) data, many datasets still cannot be shared. Federated analysis methods can enable multisite studies that do not require the sharing of participant-level information. However, there are ...

Article GUID: 42146517

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional bra ...

Article GUID: 42208339

Author(s): Marsh JD; Silva NCBS; Gill DP; Riggin B; Zou G; Stranges S; Zwarenstein M; Petrella RJ;

Background/objectives: To describe the program-related costs and estimate the cost-effectiveness of Hockey Fans In Training (Hockey FIT), a gender-sensitized lifestyle intervention, over a 1-year period. Subjects/methods: We conducted a pragmatic, cluster randomized trial among men aged 35-65 years with a body mass index =27 kg/m2, in 39 community-based ...

Article GUID: 42209661

Author(s): Sander-Montant A; Fibla L; Killam H; Byers-Heinlein K;

A persistent challenge in experimental developmental psychology is determining which of many possible outcome measures best captures underlying behaviors and processes. In the looking-while-listening paradigm for studying early word comprehension, researchers have developed more than 12 distinct outcome measures, but have limited empirical basis for choos ...

Article GUID: 42206598

Author(s): Clayton EJ; Smith-Uffen M; Tribble TW; Duennwald ML; Kohalmi SE;

Background: Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, requ ...

Article GUID: 42204708

Author(s): Câmara GS; Spiech C; Solli S; Bang B; Rogulina O; Laeng B; Danielsen A;

Musicians convey timing "feels" in groove-based performance by manipulating onset asynchrony between instruments and the durational ratio of metrical subdivisions (non-isochrony, or "swing"). The present study tested whether listeners perceive such fine-grained timing deviations by measuring the just-noticeable difference (JND) thresho ...

Article GUID: 42201766