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Dynamics of karyotype evolution

Author(s): Kuzmin E; Baker TM; Van Loo P; Glass L;

In the evolution of species, the karyotype changes with a timescale of tens to hundreds of thousand years. In the development of cancer, the karyotype often is modified in cancerous cells over the lifetime of an individual. Characterizing these changes and ...

Article GUID: 38717409


Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring

Author(s): Kuzmin E; Baker TM; Lesluyes T; Monlong J; Abe KT; Coelho PP; Schwartz M; Del Corpo J; Zou D; Morin G; Pacis A; Yang Y; Martinez C; Barber J ...

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromoso ...

Article GUID: 38517886


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