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MVComp toolbox: MultiVariate Comparisons of brain MRI features accounting for common information across metrics

Author(s): Tremblay SA; Alasmar Z; Pirhadi A; Carbonell F; Iturria-Medina Y; Gauthier CJ; Steele CJ;

Multivariate approaches have recently gained in popularity to address the physiological unspecificity of neuroimaging metrics and to better characterize the complexity of biological processes underlying behavior. However, commonly used approaches are biased ...

Article GUID: 38463982


Iron deposition and distribution across the hippocampus is associated with pattern separation and pattern completion in older adults at risk for Alzheimer's disease

Author(s): Zhou J; Wearn A; Huck J; Hughes C; Baracchini G; Tremblay-Mercier J; Poirier J; Villeneuve S; Tardif CL; Chakravarty MM; Daugherty AM; Gauth ...

Elevated iron deposition in the brain has been observed in older adult humans and persons with Alzheimer's disease (AD), and has been associated with lower cognitive performance. We investigate ...

Article GUID: 38388425


Decreased long-range temporal correlations in the resting-state functional magentic resonance imaging blood-oxygen-level-dependent signal reflect motor sequence learning up to 2 weeks following training

Author(s): Jäger AP; Bailey A; Huntenburg JM; Tardif CL; Villringer A; Gauthier CJ; Nikulin V; Bazin PL; Steele CJ; ...

Decreased long-range temporal correlations (LRTC) in brain signals can be used to measure cognitive effort during task execution. Here, we examined how learning a motor sequence affects long-range ...

Article GUID: 38124341


Modeling venous bias in resting state functional MRI metrics

Author(s): Huck J; Jäger AT; Schneider U; Grahl S; Fan AP; Tardif C; Villringer A; Bazin PL; Steele CJ; Gauthier CJ; ...

Resting-state (rs) functional magnetic resonance imaging (fMRI) is used to detect low-frequency fluctuations in the blood oxygen-level dependent (BOLD) signal across brain regions. Correlations bet ...

Article GUID: 37498014


Sex-specific relationships between obesity, physical activity, and gray and white matter volume in cognitively unimpaired older adults

Author(s): Intzandt B; Sanami S; Huck J; Villeneuve S; Bherer L; Gauthier CJ;

Independently, obesity and physical activity (PA) influence cerebral structure in aging, yet their interaction has not been investigated. We examined sex differences in the relationships among PA, obesity, and cerebral structure in aging with 340 participan ...

Article GUID: 36781598


Cerebral blood flow in schizophrenia: A systematic review and meta-analysis of MRI-based studies

Author(s): Percie du Sert O; Unrau J; Gauthier CJ; Chakravarty M; Malla A; Lepage M; Raucher-Chéné D; ...

Introduction: Schizophrenia-spectrum disorders (SSD) represent one of the leading causes of disability worldwide and are usually underpinned by neurodevelopmental brain abnormaliti ...

Article GUID: 36341843


Motor sequences; separating the sequence from the motor. A longitudinal rsfMRI study

Author(s): Jäger AP; Huntenburg JM; Tremblay SA; Schneider U; Grahl S; Huck J; Tardif CL; Villringer A; Gauthier CJ; Bazin PL; Steele CJ; ...

In motor learning, sequence specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting s ...

Article GUID: 34704176


Sex moderations in the relationship between aortic stiffness, cognition, and cerebrovascular reactivity in healthy older adults

Author(s): Sabra D; Intzandt B; Desjardins-Crepeau L; Langeard A; Steele CJ; Frouin F; Hoge RD; Bherer L; Gauthier CJ; ...

It is well established that sex differences exist in the manifestation of vascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cogniti ...

Article GUID: 34582484


Comparing the effect of Cognitive vs. Exercise Training on brain MRI outcomes in healthy older adults: A systematic review

Author(s): Intzandt B; Vrinceanu T; Huck J; Vincent T; Montero-Odasso M; Gauthier CJ; Bherer L;

Aging is associated with cognitive decline. Importantly cognition and cerebral health is enhanced with interventions like cognitive (CT) and exercise training (ET). However, effects of CT and ET interventions on brain magnetic resonance imaging outcomes hav ...

Article GUID: 34245760


White matter microstructural changes in short-term learning of a continuous visuomotor sequence

Author(s): Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ; ...

Efficient neural transmission is crucial for optimal brain function, yet the plastic potential of white matter (WM) has long been overlooked. Growing evidence now shows that modifications to axons ...

Article GUID: 33885965


Associations Between Relative Morning Blood Pressure, Cerebral Blood Flow, and Memory in Older Adults Treated and Controlled for Hypertension

Author(s): Noriega de la Colina A; Badji A; Robitaille-Grou MC; Gagnon C; Boshkovski T; Lamarre-Cliche M; Joubert S; Gauthier CJ; Bherer L; Cohen-Adad ...

Hypertension, elevated morning blood pressure (BP) surges, and circadian BP variability constitute risk factors for cerebrovascular events. Nevertheless, while evidence indicates that hypertension ...

Article GUID: 33775122


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