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A two-tiered system for selective receptor and transporter protein degradation

Author(s): Golden CK; Kazmirchuk TDD; McNally EK; El Eissawi M; Gokbayrak ZD; Richard JD; Brett CL;

Diverse physiology relies on receptor and transporter protein down-regulation and degradation mediated by ESCRTs. Loss-of-function mutations in human ESCRT genes linked to cancers and neurological disorders are thought to block this process. However, when h ...

Article GUID: 36215320


Acetate and hypertonic stress stimulate vacuole membrane fission using distinct mechanisms

Author(s): Gokbayrak ZD; Patel D; Brett CL;

Vacuoles in plants and fungi play critical roles in cell metabolism and osmoregulation. To support these functions, vacuoles change their morphology, e.g. they fragment when these organisms are challenged with draught, high salinity or metabolic stress (e.g ...

Article GUID: 35834522


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