Author(s): Hervé V; KaAli OB; Benali H; Brouillette J;

Background: One of the main neuropathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid-beta oligomers (Aßo), which begins in the brain approximately 15 years prior to the onset of clinical symptoms. Aßo-induced neuronal hyperactivity has emerged as an early functional characteristic of AD, contributing to synaptic deficits, ...

Article GUID: 41436083

Author(s): Borrie MJ; Phillips NA; Best S; Anastasiou-Ventura P; Aydogan T; Beaudoin C; Beuk J; Celotto I; Cole L; Das S; Fogarty J; Fouquet C; Gnassi L; Henri-Bellemare C; Pilon R; Sands J; Stirbu A; Truemner J; Chan S; Tucker A; Gajraj J; Bhangu ...

Background: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) used wide inclusion criteria recruiting participants across the spectrum from normal cognition to cognitive impairment to all types of clinical dementia, including mixed dementia. 1173 participants comprising ...

Article GUID: 41435411

Author(s): Gurve D; Centen AP; Slack PJ; Dang-Vu TT; Belleville S; Anderson ND; Montero-Odasso M; Nygaard HB; Chertkow H; Feldman HH; Brewster PWH; Lim A;

Background: Older adults experience considerable day-to-day variability in cognitive function. We aimed to test the hypothesis that this is in part related to sleep, and determine which EEG sleep features are most important in supporting day to day cognitive resilience. Method: We analyzed data ...

Article GUID: 41434309

Author(s): Lamontagne-Kam D; Rahimabadi A; Bello DG; Lavallée-Beaulieu M; Fermawi AE; Bonenfant L; Nanci A; Benali H; Brouillette J;

Background: Tau pathology is an important neuropathological marker of Alzheimer's Disease (AD) and correlates closely with neurodegeneration and cognitive decline. To date, much of the work examining tau propagation has been performed using mutated tau and/or transgenic animal models. Since t ...

Article GUID: 41435278

Author(s): Shafagh SH; Deen I; Packirisamy M;

The fabrication of conductive polymer composites (CPCs) using polydimethylsiloxane (PDMS) and poly(3,4-ethylene dioxythiophene): poly(4-styrene-sulfonate) (PEDOT: PSS) as a matrix with multi-walled carbon nanotubes (MWCNTs) and silver nanoparticles (AgNPs) as fillers was investigated to determine their potential for use in applications such as electromagn ...

Article GUID: 41424586

Author(s): Harriman C; Ke Q; Vlugt TJH; Howarth AJ; Simon CM;

Atmospheric water harvesting (AWH) is a method to obtain clean water in remote or underdeveloped regions including, but not limited to, those with an arid or desert climate. For passive (i.e., relying on ambient cooling and, for heating, natural sunlight?as opposed to an external power source), adsorbent-based AWH, an adsorbent bed is employed to capture ...

Article GUID: 41427123

Author(s): Morrison K; Pottier P; Pollo P; Ricolfi L; Williams C; Yang Y; Beillouin D; Cardoso SJ; Ferreira V; Gallagher B; Gan JL; Hao G; Keikha M; Kozlowsky-Suzuki B; Kiran Kumara TM; Latterini F; Leverkus AB; Macartney EL; Manrique SM; Martinig ...

Meta-analysis is commonly a core component of systematic reviews and has become an important method to reconcile conflicting findings, increase statistical power, and chart new research directions. However, poor reporting practices make it challenging to evaluate the validity of meta-analyses. De ...

Article GUID: 41411971

Author(s): Gibelli J; Michaelides S; Won H; Chamlian B; Bampfylde C; Maclean B; Giroux P; Gray QZ; Voyageur M; Jeon HB; Bouchard R; Fraser DJ;

Contaminants in harvested species can pose serious concerns for health and food security. However, the risks of contaminant exposure can be challenging to track as many species migrate extensively between breeding and feeding environments and usually form genetically distinct populations. Such in ...

Article GUID: 41380599

Author(s): Tian M; Mohammadzadeh A; Taghavifar H; Sakthivel R; Zhang C;

In this paper, a new control approach is proposed for the synchronization and stabilization of a class of chaotic systems with unknown dynamics and input nonlinearities. Type-3 fuzzy logic systems (T3-FLSs) are developed to adaptively model the dynamics of both master and slave systems in real time. The input is affected by sector-bounded hysteresis and q ...

Article GUID: 41381323

Author(s): Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H;

Background"Inflammaging" describes chronic low-grade inflammation observed in aging individuals. It may play a major role in neurodegeneration.ObjectiveTo assess blood inflammatory markers in older adults. We hypothesized that elevated inflammation would be found in some cognitively nor ...

Article GUID: 41358624

Author(s): Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ;

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a marker of vascular stiffness, are sensitive biomarkers of early vascular dysfunction associated with ...

Article GUID: 41353310