Author(s): Esber GR; Usypchuk A; Saini S; Deroche M; Iordanova MD; Schoenbaum G;

The orbitofrontal cortex (OFC) is often proposed to function as a value integrator; however, alternative accounts focus on its role in representing associative structures that specify the probability and sensory identity of future outcomes. These two accoun ...

Article GUID: 38042330

Author(s): Roque PS; Thörn Perez C; Hooshmandi M; Wong C; Eslamizade MJ; Heshmati S; Brown N; Sharma V; Lister KC; Goyon VM; Neagu-Lund L; Shen C; Dacc ...

Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying lon ...

Article GUID: 36394958

Author(s): Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD;

Background: Adaptive behavior depends on the delicate and dynamic balance between acquisition and extinction memories. Disruption of this balance, particularly when the extinction of memory loses control over behavior, is the root of treatment failure of ma ...

Article GUID: 36336498

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

No abstract

Article GUID: 36006415

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

Rationale and objective: Learning to inhibit acquired fear responses is fundamental to adaptive behavior. Two procedures that support such learning are extinction and overexpectation. In extinction, an expected outcome is omitted, whereas in overexpectation ...

Article GUID: 35932299

Author(s): Gostolupce D; Lay BPP; Maes EJP; Iordanova MD;

Associative learning is often considered to require the physical presence of stimuli in the environment in order for them to be linked. This, however, is not a necessary condition for learning. Indeed, associative relationships can form between events that ...

Article GUID: 35517574

Author(s): Kang M; Reverte I; Volz S; Kaufman K; Fevola S; Matarazzo A; Alhazmi FH; Marquez I; Iordanova MD; Esber GR; ...

A fundamental assumption of learning theories is that the credit assigned to predictive cues is not simply determined by their probability of reinforcement, but by their ability to compete with oth ...

Article GUID: 34376741

Author(s): Gostolupce D; Iordanova MD; Lay BPP;

Adaptive behaviour is under the potent control of environmental cues. Such cues can acquire value by virtue of their associations with outcomes of motivational significance, be they appetitive or aversive. There are at least two ways through which an enviro ...

Article GUID: 34197867

Author(s): Bradfield LA; Iordanova MD;

A new study has found that neurons within a structure of the rat midbrain known as the retrorubral field show diverse responses to stimuli that signal different levels of threat, as well as a separate pattern of diverse responses to differentially predicted ...

Article GUID: 34033766

Author(s): Iordanova MD, Yau JO, McDannald MA, Corbit LH

Prediction error, defined by the discrepancy between real and expected outcomes, lies at the core of associative learning. Behavioural investigations have provided evidence that prediction error up- and down-regulates associative relationships, and allocate ...

Article GUID: 33453307

Author(s): Manning EE, Bradfield LA, Iordanova MD

In complex environments, organisms must respond adaptively to situations despite conflicting information. Under natural (i.e. non-laboratory) circumstances, it is rare that cues or responses are consistently paired with a single outcome. Inconsistent pairin ...

Article GUID: 33035525