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Design, Synthesis, and Acid-Responsive Disassembly of Shell-Sheddable Block Copolymer Labeled with Benzaldehyde Acetal Junction

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK;

Smart nanoassemblies degradable through the cleavage of acid-labile linkages have attracted significant attention because of their biological relevance found in tumor tissues. Despite their high potential to achieve controlled/enhanced drug release, a syste ...

Article GUID: 38499007


Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide

Author(s): Choi M; Jazani AM; Oh JK; Noh SM;

Nitric oxide (NO) plays a critical role as an important signaling molecule for a variety of biological functions, particularly inhibiting cell proliferation or killing target pathogens. To deliver active radical NO gaseous molecule whose half-life is a few ...

Article GUID: 35683912


Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies

Author(s): Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK;

Acid-degradable (or acid-cleavable) polymeric nanoassemblies have witnessed significant progress in anti-cancer drug delivery. However, conventional nanoassemblies designed with acid-cleavable linkages at a single location have several challenges, such as, ...

Article GUID: 34050688


Macromolecularly Engineered Thermoreversible Heterogeneous Self-Healable Networks Encapsulating Reactive Multidentate Block Copolymer-Stabilized Carbon Nanotubes

Author(s): Zhang G; Patel T; Nellepalli P; Bhagat S; Hase H; Jazani AM; Salzmann I; Ye Z; Oh JK;

The development of heterogeneous covalent adaptable networks (CANs) embedded with carbon nanotubes (CNTs) that undergo reversible dissociation/recombination through thermoreversibility has been significantly explored. However, the carbon nanotube (CNT)-inco ...

Article GUID: 33988899


Microfluidic Shear Processing Control of Biological Reduction Stimuli-Responsive Polymer Nanoparticles for Drug Delivery.

Author(s): Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of ...

Article GUID: 33455300


Facile Strategies to Synthesize Dual Location Dual Acidic pH/Reduction-Responsive Degradable Block Copolymers Bearing Acetal/Disulfide Block Junctions and Disulfide Pendants.

Author(s): Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK

ACS Omega. 2018 Aug 31;3(8):8980-8991 Authors: Jazani AM, Arezi N, Maruya-Li K, Jung S, Oh JK

Article GUID: 31459031


PLA-Based Triblock Copolymer Micelles Exhibiting Dual Acidic pH/Reduction Responses at Dual Core and Core/Corona Interface Locations.

Author(s): Bawa KK, Jazani AM, Shetty C, Oh JK

Macromol Rapid Commun. 2018 Dec;39(24):e1800477 Authors: Bawa KK, Jazani AM, Shetty C, Oh JK

Article GUID: 30286258


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