Author(s): Algallal HE; Laplante I; Casale D; Najafipashaki S; Pomerleau A; Paquette T; Samaha AN;

Rationale: Cocaine addiction is marked by high relapse rates, often triggered by drug-associated cues in the environment. These can be conditioned stimuli (CSs), which occur after drug intake and signal drug delivery, and discriminative stimuli (DSs), which signal that seeking responses will produce drug, before any such responses have been initiated (i.e ...

Article GUID: 41372546

Author(s): LeCocq MR; Mainville-Berthiaume A; Laplante I; Samaha AN;

Background: Reward-associated cues guide reward-seeking behaviours. These cues include conditioned stimuli (CSs), which occur following seeking actions and predict reward delivery, and discriminative stimuli (DSs), which occur response-independently and signal that a seeking action will produce reward. Metabotropic group II glutamate (mGlu2/3) receptors i ...

Article GUID: 40341317

Author(s): Ndiaye NA; Shamleh SA; Casale D; Castaneda-Ouellet S; Laplante I; Robinson MJF; Samaha AN;

Rationale: When people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include conditioned stimuli (CSs) signaling drug delivery and discriminative stimuli (DSs) signaling drug availability. Compared to CS effects, DS effects are ...

Article GUID: 38767684