Author(s): Jobin B; Phillips NA; Frasnelli J; Boller B;

BackgroundOlfactory identification decline is a known early marker of Alzheimer's disease and is already present at the mild cognitive impairment (MCI) stage. While being linked with episodic memory, its predictive value for cognitive performance and distinguishing between clinical stages remains unclear.ObjectiveThis study examined (1) the predictive ...

Article GUID: 40944318

Author(s): Sun B; Yang JG; Wang Z; Wang Z; Feng W; Li X; Liu SN; Li J; Zhu YQ; Zhang P; Wang W;

Background: The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in-depth research on the selective mechanism of m6A methylation is still lacking. Methods: In this research, meRIP sequencing, mRNA sequencing, meRIP, luciferase ...

Article GUID: 40051055

Author(s): Gibelli J; Won H; Michaelides S; Jeon HB; Fraser DJ;

The contributions of distinct populations to annual harvests provide key insights to conservation, especially in migratory species that return to specific reproductive areas. In this context, genetic stock identification (GSI) requires reference samples from source populations to assign harvested individuals, yet sampling might be challenging as reproduct ...

Article GUID: 39995301

Author(s): Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ;

Intraspecific variation is important for species' long-term persistence in changing environments. Conservation strategies targeting intraspecific variation often rely on the identification of management or policy units below the species level based on biological differences among populations. ...

Article GUID: 39730611

Author(s): Barati Darband G; Iravani D; Zhang M; Maleki M; Huang S; Khoshfetrat SM; Andaveh R; Li J;

Electrochemical water splitting, with its oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), is undoubtedly the most eco-friendly and sustainable method to produce hydrogen. However, water splitting still requires improvement due to the high energy consumption caused by the slow kinetics and large thermodynamic potential requirements o ...

Article GUID: 39655509

Author(s): Ali MA; Sardar MF; Dar AA; Niaz M; Ali J; Wang Q; Zheng Y; Luo Y; Albasher G; Li F;

Pollutants in soil, particularly chromium (Cr), pose high environmental and health risks due to their persistence, bioavailability, and potential for causing toxicity. Cr impairment in plants act as a deleterious environmental pollutant that enters the food chain and eventually disturbs human health. Current study demonstrated the potential of integrative ...

Article GUID: 39190219

Author(s): Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT;

Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to ident ...

Article GUID: 38659875

Author(s): Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Thomas Yeo BT;

Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to ident ...

Article GUID: 38559143

Author(s): Li J; Yang S; Wu Y; Wang R; Liu Y; Liu J; Ye Z; Tang R; Whiteway M; Lv Q; Yan L;

In the respiratory chain of the majority of aerobic organisms, the enzyme alternative oxidase (AOX) functions as the terminal oxidase and has important roles in maintaining metabolic and signaling homeostasis in mitochondria. AOX endows the respiratory system with flexibility in the coupling among the carbon metabolism pathway, electron transport chain (E ...

Article GUID: 38524433

Author(s): Yang JG; Sun B; Wang Z; Li X; Gao JH; Qian JJ; Li J; Wei WJ; Zhang P; Wang W;

Osteoporosis has a profound influence on public health. First-line bisphosphonates often cause osteonecrosis of the jaw meanwhile inhibiting osteoclasts. Therefore, it is important to develop effective treatments. The results of this study showed that the increased level of NFATc1 m6A methylation caused by zoledronic acid (ZOL), with 4249A as the function ...

Article GUID: 37957146

Author(s): Sultana S; Abdullah M; Li J; Hochstrasser M; Kachroo AH;

Yeast and humans share thousands of genes despite a billion years of evolutionary divergence. While many human genes can functionally replace their yeast counterparts, nearly half of the tested shared genes cannot. For example, most yeast proteasome subunits are "humanizable", except subunits comprising the ß-ring core, including ß2c (HsPSMB7, a constitut ...

Article GUID: 37364278