Author(s): Maarouf-Mesli N; Fonseca JC; Harvey SM; Chauhan PS; Mulumba M; Ahsanullah None; Selka A; Meneksedag Erol D; Chemtob S; Ong H; Polyak F; Lubell WD;

Modern macrocyclic peptides feature unnatural elements that are used to improve the activity and pharmacokinetic properties. Chemistry beyond peptide synthesis must, however, be employed to introduce such elements. Notably, application of the copper-catalyzed aldehyde-alkyne-amine A3-reaction in ...

Article GUID: 42049622

Author(s): Nazeer N; Kooner N; Ghimire A; Rainey JK; Lubell WD; Meneksedag-Erol D; Ahmed M;

Lactam cross-links have been employed to stabilize the helical secondary structure and enhance the activity and physiological stability of antimicrobial peptides; however, stabilization of ß-sheets via lactamization has not been observed. In the present study, lactams between the side chains of C- and N-terminal residues have been used to stabilize the ß- ...

Article GUID: 38771638

Author(s): Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Biomedicines. 2019 Oct 18;7(4): Authors: Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Article GUID: 31635379