Author(s): Chowdhury FR; Mercado LD; Kharitonov K; Findlay BL;

The rise of antimicrobial resistance as a global health concern has led to a strong interest in compounds able to inhibit the growth of bacteria without detectable levels of resistance evolution. A number of these compounds have been reported in recent years, including the tridecaptins, a small family of lipopeptides typified by the synthetic analogue oct ...

Article GUID: 39832423

Author(s): Lander AJ; Mercado LD; Li X; Taily IM; Findlay BL; Jin Y; Luk LYP;

Tryptophan is frequently found on the surface of membrane-associated proteins that interact with the lipid membrane. However, because of their multifaceted interactions, it is difficult to pinpoint the structure-activity relationship of each tryptophan residue. Here, we describe the use of racemic protein crystallography to probe dedicated tryptophan inte ...

Article GUID: 37464011