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Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition

Author(s): Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ;

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a marker of vascular stiffness, are sensitive biomarkers of early vascular dysfunction associated with ...

Article GUID: 41353310


Human short-term memory learning based on dynamic glutamate levels and oscillatory activities: concurrent metabolic and electrophysiological studies using event-related functional-MRS and EEG modalities

Author(s): Mohammadi H; Zargaran SJ; Khajehpour H; Adibi I; Rahimiforoushani A; Karimi S; Serej ND; Alam NR;

Short-term memory (STM) temporarily stores sensory information, critical for synaptic plasticity, memory, and learning, and is regulated by the glutamate-gated NMDA receptor. While the frontal and parieto-occipital cortices have been implicated in STM, the electrochemical dynamics of the right he ...

Article GUID: 41171530


Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol

Author(s): Bherer L; Vrinceanu T; Dupuy EG; Gayda M; Vincent T; Magnan PO; Mohammadi H; Gauthier C; Gagnon C; Duchesne S; Erickson KI; Gagnon D; Lesage F; Lupien S; Poirier J; Dubé MP; Thorin É; Juneau M; Breton J; Belleville S; Ferland G; Gaudreau ...

Background: Lifestyle factors like exercise and cognitive stimulation might help improve cognitive performance in older adults. However, studies investigating this, reported mixed results. Most of the data supporting the benefit of exercise comes from cross-sectional studies, cohort studies, or s ...

Article GUID: 40625372


Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility

Author(s): Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ;

Cerebrovascular reactivity (CVR) and cerebral pulsatility (CP) are important indicators of cerebrovascular health, which are associated with physical activity (PA). While sex differences influence the impact of PA on cerebrovascular health, sex-specific effects of PA intensity and dose on CP and CVR remains unknown. This study aimed to evaluate the sex-sp ...

Article GUID: 40079560


Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility

Author(s): Potvin-Jutras Z; Intzandt B; Mohammadi H; Liu P; Chen JJ; Gauthier CJ;

Cerebrovascular reactivity (CVR) and cerebral pulsatility (CP) are important indicators of cerebrovascular health and have been shown to be associated with physical activity (PA). Sex differences have been shown to influence the impact of PA on cerebrovascular health. However, the sex-specific effects of PA on CP and CVR, particularly in relation to inten ...

Article GUID: 39416007


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